Long-term non-invasive ventilation increases chemosensitivity and leptin in obesity-hypoventilation syndrome

Stefania Redolfi, Luciano Corda, Giuseppe La Piana, Sara Spandrio, Paola Prometti, Claudio Tantucci

Research output: Contribution to journalArticlepeer-review


Background: Long-term nocturnal non-invasive mechanical ventilation (NIMV) is an effective treatment for obesity-hypoventilation syndrome (OHS), improving central carbon dioxide (CO2) sensitivity. Leptin might contribute to sustain adequate ventilation in obesity. The aim of the study was to investigate the role of leptin in the OHS pathogenesis looking at its relationship to CO2 sensitivity before and after NIMV in OHS patients. Methods: In six obese patients (3F/3M; aged 63±9 yr; BMI 47.0±4.5 kg/m2) with OHS and without obstructive sleep apnoea-hypopnoea (OSAH) diurnal arterial blood gases, fasting plasma leptin concentration and CO2 chemosensitivity were determined before and after 10.3±5.6 (range 6-20) months of NIMV. Results: After NIMV improvements were observed in gas exchange (PaO2 from 51.3±6.7 to 75.0±10.3 mmHg, p2 from 55.5±4.8 to 43.7±1.2 mmHg, p3 -] from 33.3±3.8 to 29.8±1.7 mmol/l, p2 chemosensitivity, measured as P0.1/PetCO2 slope (from 0.09±0.07 to 0.18±0.07 cmH2O/mmHg, pE/PetCO2 slope (from 0.4±0.3 to 0.9±0.5 l/min/mmHg, p = 0.07). Plasma leptin increased from 34.5±21.1 ng/ml to 50.2±22.9 ng/ml (p0.1/PetCO2 slope correlated with percent changes of plasma leptin (r2 = 0.79, p

Original languageEnglish
Pages (from-to)1191-1195
Number of pages5
JournalRespiratory Medicine
Issue number6
Publication statusPublished - Jun 2007


  • Chemosensitivity
  • Leptin
  • Non-invasive mechanical ventilation
  • Obesity-hypoventilation syndrome

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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