Long-term omeprazole therapy in peptic ulcer disease: Gastrin, endocrine cell growth, and gastritis

Regina Lamberts, Werner Creutzfeldt, Hans G. Strüber, Gorik Brunner, Enrico Solcia

Research output: Contribution to journalArticle

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Abstract

Background: The effects of chronic drug-induced hypergastrinemia on the exocrine and endocrine stomach are still incompletely understood. Chronic hypergastrinemia in rats and humans is associated with gastric argyrophil cell hyperplasia. Methods: Seventy-four patients with chronic ranitidine-resistant ulcerations were treated chronically with omeprazole (median observation period 48 [6-84] months). Results: Median fasting serum gastrin levels increased from a pretreatment value of 74-145 pg/mL after 3 months. No further increase was observed thereafter. The finding of atrophic gastritis increased from 1.8% to 20.8% after 5 years. A doubling of the mean argyrophil cell volume density (0.36% vs. 0.74% after 5 years; P <0.01%) was paralleled by a decrease in the normal endocrine cell growth pattern from 64.3% to 33.3% and an increase in micronodular hyperplasia (8.9% vs. 16.7%). These changes correlated with the severity of corpus gastritis and seemed to be more disease- than drug-related. No statistically significant changes were observed in the antral G- and D-cell volume densities under therapy. Conclusions: Long-term omeprazole therapy in humans results in moderate hypergastrinemia and a significant argyrophil cell hyperplasia, which are correlated to the grade of corpus gastritis. Because hypergastrinemia and gastritis are closely related, it is difficult to quantitatively assess their respective role in this process.

Original languageEnglish
Pages (from-to)1356-1370
Number of pages15
JournalGastroenterology
Volume104
Issue number5
Publication statusPublished - 1993

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Gastrin-Secreting Cells
Endocrine Cells
Omeprazole
Gastritis
Peptic Ulcer
Hyperplasia
Stomach
Growth
Cell Count
Atrophic Gastritis
Ranitidine
Erythrocyte Indices
Somatostatin-Secreting Cells
Gastrins
Cell Size
Pharmaceutical Preparations
Fasting
Therapeutics
Observation
Serum

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Lamberts, R., Creutzfeldt, W., Strüber, H. G., Brunner, G., & Solcia, E. (1993). Long-term omeprazole therapy in peptic ulcer disease: Gastrin, endocrine cell growth, and gastritis. Gastroenterology, 104(5), 1356-1370.

Long-term omeprazole therapy in peptic ulcer disease : Gastrin, endocrine cell growth, and gastritis. / Lamberts, Regina; Creutzfeldt, Werner; Strüber, Hans G.; Brunner, Gorik; Solcia, Enrico.

In: Gastroenterology, Vol. 104, No. 5, 1993, p. 1356-1370.

Research output: Contribution to journalArticle

Lamberts, R, Creutzfeldt, W, Strüber, HG, Brunner, G & Solcia, E 1993, 'Long-term omeprazole therapy in peptic ulcer disease: Gastrin, endocrine cell growth, and gastritis', Gastroenterology, vol. 104, no. 5, pp. 1356-1370.
Lamberts, Regina ; Creutzfeldt, Werner ; Strüber, Hans G. ; Brunner, Gorik ; Solcia, Enrico. / Long-term omeprazole therapy in peptic ulcer disease : Gastrin, endocrine cell growth, and gastritis. In: Gastroenterology. 1993 ; Vol. 104, No. 5. pp. 1356-1370.
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