Abstract
Baclofen is widely used to control spasticity in children with cerebral palsy. Several publications described clinical adverse effects of baclofen oral treatment, but the effect of baclofen on seizure potentiation is still controversial. We describe a 10-year-old female patient with cerebral palsy, epilepsy, and mental retardation who developed clinical adverse effects (confusion, agitated state, insomnia, diffuse hypotonia, and hyporeflexia) and electroencephalographic (EEG) changes (quasiperiodic, generalized burst of sharp waves that take up >50% of standard EEG) during long-term oral baclofen treatment, after gradually increasing the dosage but still within the therapeutic dose. Our case showed clearly that the EEG changes in our patient, with a history of epilepsy in good control, have been induced by the baclofen increase, and we describe the possible mechanisms that could explain proconvulsive effect of baclofen.
| Original language | English |
|---|---|
| Pages (from-to) | 1272-1274 |
| Number of pages | 3 |
| Journal | Journal of Child Neurology |
| Volume | 25 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Oct 2010 |
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Keywords
- baclofen
- cerebral palsy
- seizure
ASJC Scopus subject areas
- Clinical Neurology
- Pediatrics, Perinatology, and Child Health
Cite this
Long-term oral baclofen treatment in a child with cerebral palsy : Electroencephalographic changes and clinical adverse effects. / De Rinaldis, Marta; Losito, Luciana; Gennaro, Leonarda; Trabacca, Antonio.
In: Journal of Child Neurology, Vol. 25, No. 10, 10.2010, p. 1272-1274.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Long-term oral baclofen treatment in a child with cerebral palsy
T2 - Electroencephalographic changes and clinical adverse effects
AU - De Rinaldis, Marta
AU - Losito, Luciana
AU - Gennaro, Leonarda
AU - Trabacca, Antonio
PY - 2010/10
Y1 - 2010/10
N2 - Baclofen is widely used to control spasticity in children with cerebral palsy. Several publications described clinical adverse effects of baclofen oral treatment, but the effect of baclofen on seizure potentiation is still controversial. We describe a 10-year-old female patient with cerebral palsy, epilepsy, and mental retardation who developed clinical adverse effects (confusion, agitated state, insomnia, diffuse hypotonia, and hyporeflexia) and electroencephalographic (EEG) changes (quasiperiodic, generalized burst of sharp waves that take up >50% of standard EEG) during long-term oral baclofen treatment, after gradually increasing the dosage but still within the therapeutic dose. Our case showed clearly that the EEG changes in our patient, with a history of epilepsy in good control, have been induced by the baclofen increase, and we describe the possible mechanisms that could explain proconvulsive effect of baclofen.
AB - Baclofen is widely used to control spasticity in children with cerebral palsy. Several publications described clinical adverse effects of baclofen oral treatment, but the effect of baclofen on seizure potentiation is still controversial. We describe a 10-year-old female patient with cerebral palsy, epilepsy, and mental retardation who developed clinical adverse effects (confusion, agitated state, insomnia, diffuse hypotonia, and hyporeflexia) and electroencephalographic (EEG) changes (quasiperiodic, generalized burst of sharp waves that take up >50% of standard EEG) during long-term oral baclofen treatment, after gradually increasing the dosage but still within the therapeutic dose. Our case showed clearly that the EEG changes in our patient, with a history of epilepsy in good control, have been induced by the baclofen increase, and we describe the possible mechanisms that could explain proconvulsive effect of baclofen.
KW - baclofen
KW - cerebral palsy
KW - seizure
UR - http://www.scopus.com/inward/record.url?scp=77957991840&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77957991840&partnerID=8YFLogxK
U2 - 10.1177/0883073809357243
DO - 10.1177/0883073809357243
M3 - Article
VL - 25
SP - 1272
EP - 1274
JO - Journal of Child Neurology
JF - Journal of Child Neurology
SN - 0883-0738
IS - 10
ER -