Long-term oral baclofen treatment in a child with cerebral palsy

Electroencephalographic changes and clinical adverse effects

Marta De Rinaldis, Luciana Losito, Leonarda Gennaro, Antonio Trabacca

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Baclofen is widely used to control spasticity in children with cerebral palsy. Several publications described clinical adverse effects of baclofen oral treatment, but the effect of baclofen on seizure potentiation is still controversial. We describe a 10-year-old female patient with cerebral palsy, epilepsy, and mental retardation who developed clinical adverse effects (confusion, agitated state, insomnia, diffuse hypotonia, and hyporeflexia) and electroencephalographic (EEG) changes (quasiperiodic, generalized burst of sharp waves that take up >50% of standard EEG) during long-term oral baclofen treatment, after gradually increasing the dosage but still within the therapeutic dose. Our case showed clearly that the EEG changes in our patient, with a history of epilepsy in good control, have been induced by the baclofen increase, and we describe the possible mechanisms that could explain proconvulsive effect of baclofen.

Original languageEnglish
Pages (from-to)1272-1274
Number of pages3
JournalJournal of Child Neurology
Volume25
Issue number10
DOIs
Publication statusPublished - Oct 2010

Fingerprint

Baclofen
Cerebral Palsy
Epilepsy
Therapeutics
Confusion
Abnormal Reflexes
Muscle Hypotonia
Sleep Initiation and Maintenance Disorders
Intellectual Disability
Publications
Seizures

Keywords

  • baclofen
  • cerebral palsy
  • seizure

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health

Cite this

Long-term oral baclofen treatment in a child with cerebral palsy : Electroencephalographic changes and clinical adverse effects. / De Rinaldis, Marta; Losito, Luciana; Gennaro, Leonarda; Trabacca, Antonio.

In: Journal of Child Neurology, Vol. 25, No. 10, 10.2010, p. 1272-1274.

Research output: Contribution to journalArticle

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