Long term outcome of acute pancreatitis in Italy

Results of a multicentre study

Laura Castoldi, Paolo De Rai, Alessandro Zerbi, Luca Frulloni, Generoso Uomo, Armando Gabbrielli, Claudio Bassi, Raffaele Pezzilli, S. Agugiaro, L. Turri, A. Bartoli, F. Barberini, G. Cavazzoni, F. Bartolo, D. D. Papa, C. Bassi, N. Bassi, M. Massani, A. Benedetti, G. Macarri & 108 others L. Piergallini, G. Briani, L. Bartolasi, L. Bugnano, G. M. Buonanno, C. Esposito, A. Cordovana, E. Cavina, M. Seccia, B. L P Musco, M. Barletta, E. Chilovi, A. De Guelfi, P. Chirletti, R. Caronna, S. Scozzafava, M. Cardi, E. Cirino, A. Buffone, E. Colangelo, V. Caracino, F. Cortese, A. Casentini, G. Costamagna, A. Trincali, M. Curzio, S. Clivio, S. Segato, A. D'Alessandro, V. Ambrosiani, B. D'Ambrosio, C. Chiodo, M. Dicillo, L. Reale, A. Grandolfo, P. Fabbrucci, A. Bruscino, P. Mugnaini, S. Ferrarese, I. Ugenti, G. B. Forte, P. Rocco, A. Franzè, A. Bertelè, G. Sereni, D. Friedman, L. Mariani, F. Morelli, V. Gai, C. Antro, D. Garcea, A. Gardini, E. Lucci, P. C. Giulianotti, F. Sbrana, T. Balestracci, S. M. Giulini, A. Pellizzari, M. Ronconi, S. Cimaschi, M. Grassini, S. Lacignola, C. L. Martina, L. Mazzitelli, S. M. Costarella, E. A. Reggio, P. Mello Teggia, E. Stefano, P. Cassini, G. Modica, F. Lupo, G. Giraci, F. Mosca, M. Del Chiaro, G. Mosella, G. Benassai, M. Nanni, A. D'Aristotile, P. Negro, A. Pirazzoli, P. G. Rabitti, C. Romano, G. Gerardi, B. Troianello, D. Ruscello, A. Di Stefano, S. Avelli, N. Salval, N. Bellini, P. Scalon, C. Staudacher, D. Parolini, M. Strazzabosco, S. Signorelli, U. Tedeschi, P. A. Testoni, E. Masci, A. Mariani, E. Torelli, M. R. Garcea, V. Lombardi, L. Lecconi, L. Valeri, L. Presenti, F. Alessio, M. Ventrucci, S. Virzi, A. Cipolla

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: In Italy, no long-term studies regarding the natural history of acute pancreatitis have been carried out. Aim: To report the results of a follow-up on a large series of patients hospitalised for pancreatitis. Methods: Data of 631 patients admitted to 35 Italian hospitals were retrospectively evaluated 51.7 ± 8.4 months after discharge. Results: The average recovery time after mild or severe pancreatitis was 28.2 and 53.4 days respectively. Fourteen sequelae were not resolved and 9 cases required late surgical intervention. Eighty patients (12.7%) had a second hospital admission. Of the patients with mild biliary pancreatitis, 67.9% underwent a cholecystectomy. The overall incidence of relapse was 12.7%. Mortality was 9.8% and no death was related to pancreatitis. Three patients died from carcinoma of the pancreas. Conclusion: Reported recovery time after an attack of pancreatitis was longer than expected in the mild forms. The treatment of sequelae was delayed beyond one year after discharge. The incidence of relapse of biliary pancreatitis in patients not undergoing a cholecystectomy was low, due to endoscopic treatment. Mortality from pancreatic-related causes is low, but there is an association with malignant pancreatic or ampullary tumours not diagnosed during the acute phase of the illness.

Original languageEnglish
Pages (from-to)827-832
Number of pages6
JournalDigestive and Liver Disease
Volume45
Issue number10
DOIs
Publication statusPublished - Oct 2013

Fingerprint

Pancreatitis
Italy
Multicenter Studies
Cholecystectomy
Recurrence
Mortality
Incidence
Pancreas
Carcinoma
Therapeutics
Neoplasms

Keywords

  • Acute pancreatitis follow-up
  • Biliary acute pancreatitis
  • Surgery in acute pancreatitis

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Long term outcome of acute pancreatitis in Italy : Results of a multicentre study. / Castoldi, Laura; De Rai, Paolo; Zerbi, Alessandro; Frulloni, Luca; Uomo, Generoso; Gabbrielli, Armando; Bassi, Claudio; Pezzilli, Raffaele; Agugiaro, S.; Turri, L.; Bartoli, A.; Barberini, F.; Cavazzoni, G.; Bartolo, F.; Papa, D. D.; Bassi, C.; Bassi, N.; Massani, M.; Benedetti, A.; Macarri, G.; Piergallini, L.; Briani, G.; Bartolasi, L.; Bugnano, L.; Buonanno, G. M.; Esposito, C.; Cordovana, A.; Cavina, E.; Seccia, M.; Musco, B. L P; Barletta, M.; Chilovi, E.; De Guelfi, A.; Chirletti, P.; Caronna, R.; Scozzafava, S.; Cardi, M.; Cirino, E.; Buffone, A.; Colangelo, E.; Caracino, V.; Cortese, F.; Casentini, A.; Costamagna, G.; Trincali, A.; Curzio, M.; Clivio, S.; Segato, S.; D'Alessandro, A.; Ambrosiani, V.; D'Ambrosio, B.; Chiodo, C.; Dicillo, M.; Reale, L.; Grandolfo, A.; Fabbrucci, P.; Bruscino, A.; Mugnaini, P.; Ferrarese, S.; Ugenti, I.; Forte, G. B.; Rocco, P.; Franzè, A.; Bertelè, A.; Sereni, G.; Friedman, D.; Mariani, L.; Morelli, F.; Gai, V.; Antro, C.; Garcea, D.; Gardini, A.; Lucci, E.; Giulianotti, P. C.; Sbrana, F.; Balestracci, T.; Giulini, S. M.; Pellizzari, A.; Ronconi, M.; Cimaschi, S.; Grassini, M.; Lacignola, S.; Martina, C. L.; Mazzitelli, L.; Costarella, S. M.; Reggio, E. A.; Mello Teggia, P.; Stefano, E.; Cassini, P.; Modica, G.; Lupo, F.; Giraci, G.; Mosca, F.; Del Chiaro, M.; Mosella, G.; Benassai, G.; Nanni, M.; D'Aristotile, A.; Negro, P.; Pirazzoli, A.; Rabitti, P. G.; Romano, C.; Gerardi, G.; Troianello, B.; Ruscello, D.; Di Stefano, A.; Avelli, S.; Salval, N.; Bellini, N.; Scalon, P.; Staudacher, C.; Parolini, D.; Strazzabosco, M.; Signorelli, S.; Tedeschi, U.; Testoni, P. A.; Masci, E.; Mariani, A.; Torelli, E.; Garcea, M. R.; Lombardi, V.; Lecconi, L.; Valeri, L.; Presenti, L.; Alessio, F.; Ventrucci, M.; Virzi, S.; Cipolla, A.

In: Digestive and Liver Disease, Vol. 45, No. 10, 10.2013, p. 827-832.

Research output: Contribution to journalArticle

Castoldi, L, De Rai, P, Zerbi, A, Frulloni, L, Uomo, G, Gabbrielli, A, Bassi, C, Pezzilli, R, Agugiaro, S, Turri, L, Bartoli, A, Barberini, F, Cavazzoni, G, Bartolo, F, Papa, DD, Bassi, C, Bassi, N, Massani, M, Benedetti, A, Macarri, G, Piergallini, L, Briani, G, Bartolasi, L, Bugnano, L, Buonanno, GM, Esposito, C, Cordovana, A, Cavina, E, Seccia, M, Musco, BLP, Barletta, M, Chilovi, E, De Guelfi, A, Chirletti, P, Caronna, R, Scozzafava, S, Cardi, M, Cirino, E, Buffone, A, Colangelo, E, Caracino, V, Cortese, F, Casentini, A, Costamagna, G, Trincali, A, Curzio, M, Clivio, S, Segato, S, D'Alessandro, A, Ambrosiani, V, D'Ambrosio, B, Chiodo, C, Dicillo, M, Reale, L, Grandolfo, A, Fabbrucci, P, Bruscino, A, Mugnaini, P, Ferrarese, S, Ugenti, I, Forte, GB, Rocco, P, Franzè, A, Bertelè, A, Sereni, G, Friedman, D, Mariani, L, Morelli, F, Gai, V, Antro, C, Garcea, D, Gardini, A, Lucci, E, Giulianotti, PC, Sbrana, F, Balestracci, T, Giulini, SM, Pellizzari, A, Ronconi, M, Cimaschi, S, Grassini, M, Lacignola, S, Martina, CL, Mazzitelli, L, Costarella, SM, Reggio, EA, Mello Teggia, P, Stefano, E, Cassini, P, Modica, G, Lupo, F, Giraci, G, Mosca, F, Del Chiaro, M, Mosella, G, Benassai, G, Nanni, M, D'Aristotile, A, Negro, P, Pirazzoli, A, Rabitti, PG, Romano, C, Gerardi, G, Troianello, B, Ruscello, D, Di Stefano, A, Avelli, S, Salval, N, Bellini, N, Scalon, P, Staudacher, C, Parolini, D, Strazzabosco, M, Signorelli, S, Tedeschi, U, Testoni, PA, Masci, E, Mariani, A, Torelli, E, Garcea, MR, Lombardi, V, Lecconi, L, Valeri, L, Presenti, L, Alessio, F, Ventrucci, M, Virzi, S & Cipolla, A 2013, 'Long term outcome of acute pancreatitis in Italy: Results of a multicentre study', Digestive and Liver Disease, vol. 45, no. 10, pp. 827-832. https://doi.org/10.1016/j.dld.2013.03.012
Castoldi, Laura ; De Rai, Paolo ; Zerbi, Alessandro ; Frulloni, Luca ; Uomo, Generoso ; Gabbrielli, Armando ; Bassi, Claudio ; Pezzilli, Raffaele ; Agugiaro, S. ; Turri, L. ; Bartoli, A. ; Barberini, F. ; Cavazzoni, G. ; Bartolo, F. ; Papa, D. D. ; Bassi, C. ; Bassi, N. ; Massani, M. ; Benedetti, A. ; Macarri, G. ; Piergallini, L. ; Briani, G. ; Bartolasi, L. ; Bugnano, L. ; Buonanno, G. M. ; Esposito, C. ; Cordovana, A. ; Cavina, E. ; Seccia, M. ; Musco, B. L P ; Barletta, M. ; Chilovi, E. ; De Guelfi, A. ; Chirletti, P. ; Caronna, R. ; Scozzafava, S. ; Cardi, M. ; Cirino, E. ; Buffone, A. ; Colangelo, E. ; Caracino, V. ; Cortese, F. ; Casentini, A. ; Costamagna, G. ; Trincali, A. ; Curzio, M. ; Clivio, S. ; Segato, S. ; D'Alessandro, A. ; Ambrosiani, V. ; D'Ambrosio, B. ; Chiodo, C. ; Dicillo, M. ; Reale, L. ; Grandolfo, A. ; Fabbrucci, P. ; Bruscino, A. ; Mugnaini, P. ; Ferrarese, S. ; Ugenti, I. ; Forte, G. B. ; Rocco, P. ; Franzè, A. ; Bertelè, A. ; Sereni, G. ; Friedman, D. ; Mariani, L. ; Morelli, F. ; Gai, V. ; Antro, C. ; Garcea, D. ; Gardini, A. ; Lucci, E. ; Giulianotti, P. C. ; Sbrana, F. ; Balestracci, T. ; Giulini, S. M. ; Pellizzari, A. ; Ronconi, M. ; Cimaschi, S. ; Grassini, M. ; Lacignola, S. ; Martina, C. L. ; Mazzitelli, L. ; Costarella, S. M. ; Reggio, E. A. ; Mello Teggia, P. ; Stefano, E. ; Cassini, P. ; Modica, G. ; Lupo, F. ; Giraci, G. ; Mosca, F. ; Del Chiaro, M. ; Mosella, G. ; Benassai, G. ; Nanni, M. ; D'Aristotile, A. ; Negro, P. ; Pirazzoli, A. ; Rabitti, P. G. ; Romano, C. ; Gerardi, G. ; Troianello, B. ; Ruscello, D. ; Di Stefano, A. ; Avelli, S. ; Salval, N. ; Bellini, N. ; Scalon, P. ; Staudacher, C. ; Parolini, D. ; Strazzabosco, M. ; Signorelli, S. ; Tedeschi, U. ; Testoni, P. A. ; Masci, E. ; Mariani, A. ; Torelli, E. ; Garcea, M. R. ; Lombardi, V. ; Lecconi, L. ; Valeri, L. ; Presenti, L. ; Alessio, F. ; Ventrucci, M. ; Virzi, S. ; Cipolla, A. / Long term outcome of acute pancreatitis in Italy : Results of a multicentre study. In: Digestive and Liver Disease. 2013 ; Vol. 45, No. 10. pp. 827-832.
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title = "Long term outcome of acute pancreatitis in Italy: Results of a multicentre study",
abstract = "Background: In Italy, no long-term studies regarding the natural history of acute pancreatitis have been carried out. Aim: To report the results of a follow-up on a large series of patients hospitalised for pancreatitis. Methods: Data of 631 patients admitted to 35 Italian hospitals were retrospectively evaluated 51.7 ± 8.4 months after discharge. Results: The average recovery time after mild or severe pancreatitis was 28.2 and 53.4 days respectively. Fourteen sequelae were not resolved and 9 cases required late surgical intervention. Eighty patients (12.7{\%}) had a second hospital admission. Of the patients with mild biliary pancreatitis, 67.9{\%} underwent a cholecystectomy. The overall incidence of relapse was 12.7{\%}. Mortality was 9.8{\%} and no death was related to pancreatitis. Three patients died from carcinoma of the pancreas. Conclusion: Reported recovery time after an attack of pancreatitis was longer than expected in the mild forms. The treatment of sequelae was delayed beyond one year after discharge. The incidence of relapse of biliary pancreatitis in patients not undergoing a cholecystectomy was low, due to endoscopic treatment. Mortality from pancreatic-related causes is low, but there is an association with malignant pancreatic or ampullary tumours not diagnosed during the acute phase of the illness.",
keywords = "Acute pancreatitis follow-up, Biliary acute pancreatitis, Surgery in acute pancreatitis",
author = "Laura Castoldi and {De Rai}, Paolo and Alessandro Zerbi and Luca Frulloni and Generoso Uomo and Armando Gabbrielli and Claudio Bassi and Raffaele Pezzilli and S. Agugiaro and L. Turri and A. Bartoli and F. Barberini and G. Cavazzoni and F. Bartolo and Papa, {D. D.} and C. Bassi and N. Bassi and M. Massani and A. Benedetti and G. Macarri and L. Piergallini and G. Briani and L. Bartolasi and L. Bugnano and Buonanno, {G. M.} and C. Esposito and A. Cordovana and E. Cavina and M. Seccia and Musco, {B. L P} and M. Barletta and E. Chilovi and {De Guelfi}, A. and P. Chirletti and R. Caronna and S. Scozzafava and M. Cardi and E. Cirino and A. Buffone and E. Colangelo and V. Caracino and F. Cortese and A. Casentini and G. Costamagna and A. Trincali and M. Curzio and S. Clivio and S. Segato and A. D'Alessandro and V. Ambrosiani and B. D'Ambrosio and C. Chiodo and M. Dicillo and L. Reale and A. Grandolfo and P. Fabbrucci and A. Bruscino and P. Mugnaini and S. Ferrarese and I. Ugenti and Forte, {G. B.} and P. Rocco and A. Franz{\`e} and A. Bertel{\`e} and G. Sereni and D. Friedman and L. Mariani and F. Morelli and V. Gai and C. Antro and D. Garcea and A. Gardini and E. Lucci and Giulianotti, {P. C.} and F. Sbrana and T. Balestracci and Giulini, {S. M.} and A. Pellizzari and M. Ronconi and S. Cimaschi and M. Grassini and S. Lacignola and Martina, {C. L.} and L. Mazzitelli and Costarella, {S. M.} and Reggio, {E. A.} and {Mello Teggia}, P. and E. Stefano and P. Cassini and G. Modica and F. Lupo and G. Giraci and F. Mosca and {Del Chiaro}, M. and G. Mosella and G. Benassai and M. Nanni and A. D'Aristotile and P. Negro and A. Pirazzoli and Rabitti, {P. G.} and C. Romano and G. Gerardi and B. Troianello and D. Ruscello and {Di Stefano}, A. and S. Avelli and N. Salval and N. Bellini and P. Scalon and C. Staudacher and D. Parolini and M. Strazzabosco and S. Signorelli and U. Tedeschi and Testoni, {P. A.} and E. Masci and A. Mariani and E. Torelli and Garcea, {M. R.} and V. Lombardi and L. Lecconi and L. Valeri and L. Presenti and F. Alessio and M. Ventrucci and S. Virzi and A. Cipolla",
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TY - JOUR

T1 - Long term outcome of acute pancreatitis in Italy

T2 - Results of a multicentre study

AU - Castoldi, Laura

AU - De Rai, Paolo

AU - Zerbi, Alessandro

AU - Frulloni, Luca

AU - Uomo, Generoso

AU - Gabbrielli, Armando

AU - Bassi, Claudio

AU - Pezzilli, Raffaele

AU - Agugiaro, S.

AU - Turri, L.

AU - Bartoli, A.

AU - Barberini, F.

AU - Cavazzoni, G.

AU - Bartolo, F.

AU - Papa, D. D.

AU - Bassi, C.

AU - Bassi, N.

AU - Massani, M.

AU - Benedetti, A.

AU - Macarri, G.

AU - Piergallini, L.

AU - Briani, G.

AU - Bartolasi, L.

AU - Bugnano, L.

AU - Buonanno, G. M.

AU - Esposito, C.

AU - Cordovana, A.

AU - Cavina, E.

AU - Seccia, M.

AU - Musco, B. L P

AU - Barletta, M.

AU - Chilovi, E.

AU - De Guelfi, A.

AU - Chirletti, P.

AU - Caronna, R.

AU - Scozzafava, S.

AU - Cardi, M.

AU - Cirino, E.

AU - Buffone, A.

AU - Colangelo, E.

AU - Caracino, V.

AU - Cortese, F.

AU - Casentini, A.

AU - Costamagna, G.

AU - Trincali, A.

AU - Curzio, M.

AU - Clivio, S.

AU - Segato, S.

AU - D'Alessandro, A.

AU - Ambrosiani, V.

AU - D'Ambrosio, B.

AU - Chiodo, C.

AU - Dicillo, M.

AU - Reale, L.

AU - Grandolfo, A.

AU - Fabbrucci, P.

AU - Bruscino, A.

AU - Mugnaini, P.

AU - Ferrarese, S.

AU - Ugenti, I.

AU - Forte, G. B.

AU - Rocco, P.

AU - Franzè, A.

AU - Bertelè, A.

AU - Sereni, G.

AU - Friedman, D.

AU - Mariani, L.

AU - Morelli, F.

AU - Gai, V.

AU - Antro, C.

AU - Garcea, D.

AU - Gardini, A.

AU - Lucci, E.

AU - Giulianotti, P. C.

AU - Sbrana, F.

AU - Balestracci, T.

AU - Giulini, S. M.

AU - Pellizzari, A.

AU - Ronconi, M.

AU - Cimaschi, S.

AU - Grassini, M.

AU - Lacignola, S.

AU - Martina, C. L.

AU - Mazzitelli, L.

AU - Costarella, S. M.

AU - Reggio, E. A.

AU - Mello Teggia, P.

AU - Stefano, E.

AU - Cassini, P.

AU - Modica, G.

AU - Lupo, F.

AU - Giraci, G.

AU - Mosca, F.

AU - Del Chiaro, M.

AU - Mosella, G.

AU - Benassai, G.

AU - Nanni, M.

AU - D'Aristotile, A.

AU - Negro, P.

AU - Pirazzoli, A.

AU - Rabitti, P. G.

AU - Romano, C.

AU - Gerardi, G.

AU - Troianello, B.

AU - Ruscello, D.

AU - Di Stefano, A.

AU - Avelli, S.

AU - Salval, N.

AU - Bellini, N.

AU - Scalon, P.

AU - Staudacher, C.

AU - Parolini, D.

AU - Strazzabosco, M.

AU - Signorelli, S.

AU - Tedeschi, U.

AU - Testoni, P. A.

AU - Masci, E.

AU - Mariani, A.

AU - Torelli, E.

AU - Garcea, M. R.

AU - Lombardi, V.

AU - Lecconi, L.

AU - Valeri, L.

AU - Presenti, L.

AU - Alessio, F.

AU - Ventrucci, M.

AU - Virzi, S.

AU - Cipolla, A.

PY - 2013/10

Y1 - 2013/10

N2 - Background: In Italy, no long-term studies regarding the natural history of acute pancreatitis have been carried out. Aim: To report the results of a follow-up on a large series of patients hospitalised for pancreatitis. Methods: Data of 631 patients admitted to 35 Italian hospitals were retrospectively evaluated 51.7 ± 8.4 months after discharge. Results: The average recovery time after mild or severe pancreatitis was 28.2 and 53.4 days respectively. Fourteen sequelae were not resolved and 9 cases required late surgical intervention. Eighty patients (12.7%) had a second hospital admission. Of the patients with mild biliary pancreatitis, 67.9% underwent a cholecystectomy. The overall incidence of relapse was 12.7%. Mortality was 9.8% and no death was related to pancreatitis. Three patients died from carcinoma of the pancreas. Conclusion: Reported recovery time after an attack of pancreatitis was longer than expected in the mild forms. The treatment of sequelae was delayed beyond one year after discharge. The incidence of relapse of biliary pancreatitis in patients not undergoing a cholecystectomy was low, due to endoscopic treatment. Mortality from pancreatic-related causes is low, but there is an association with malignant pancreatic or ampullary tumours not diagnosed during the acute phase of the illness.

AB - Background: In Italy, no long-term studies regarding the natural history of acute pancreatitis have been carried out. Aim: To report the results of a follow-up on a large series of patients hospitalised for pancreatitis. Methods: Data of 631 patients admitted to 35 Italian hospitals were retrospectively evaluated 51.7 ± 8.4 months after discharge. Results: The average recovery time after mild or severe pancreatitis was 28.2 and 53.4 days respectively. Fourteen sequelae were not resolved and 9 cases required late surgical intervention. Eighty patients (12.7%) had a second hospital admission. Of the patients with mild biliary pancreatitis, 67.9% underwent a cholecystectomy. The overall incidence of relapse was 12.7%. Mortality was 9.8% and no death was related to pancreatitis. Three patients died from carcinoma of the pancreas. Conclusion: Reported recovery time after an attack of pancreatitis was longer than expected in the mild forms. The treatment of sequelae was delayed beyond one year after discharge. The incidence of relapse of biliary pancreatitis in patients not undergoing a cholecystectomy was low, due to endoscopic treatment. Mortality from pancreatic-related causes is low, but there is an association with malignant pancreatic or ampullary tumours not diagnosed during the acute phase of the illness.

KW - Acute pancreatitis follow-up

KW - Biliary acute pancreatitis

KW - Surgery in acute pancreatitis

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U2 - 10.1016/j.dld.2013.03.012

DO - 10.1016/j.dld.2013.03.012

M3 - Article

VL - 45

SP - 827

EP - 832

JO - Digestive and Liver Disease

JF - Digestive and Liver Disease

SN - 1590-8658

IS - 10

ER -