Long-term outcome of cervical artery dissection: IPSYS CeAD: study protocol, rationale, and baseline data of an Italian multicenter research collaboration: Neurological Sciences

S. Bonacina, M. Grassi, M. Zedde, A. Zini, A. Bersano, C. Gandolfo, G. Silvestrelli, C. Baracchini, P. Cerrato, C. Lodigiani, S. Marcheselli, M. Paciaroni, M. Rasura, M. Cappellari, M. Del Sette, A. Cavallini, A. Morotti, G. Micieli, E.M. Lotti, M.L. DeLodoviciM. Gentile, M. Magoni, C. Azzini, M.V. Calloni, E. Giorli, M. Braga, P. La Spina, F. Melis, R. Tassi, V. Terruso, R.S. Calabrò, M. Melis, M. Sessa, M. Locatelli, S. Sanguigni, C. Zanferrari, M. Mannino, G. Calabrese, C. Dallocchio, P. Nencini, V. Bignamini, A. Adami, E. Magni, R. Bella, A. Padovani, A. Pezzini, the Italian Project on Stroke in Young Adults - Cervical Artery Dissection (IPSYS CeAD) Research Group

Research output: Contribution to journalArticlepeer-review


Long-term consequences of cervical artery dissection (CeAD), a major cause of ischemic stroke in young people, have been poorly investigated. The Italian Project on Stroke at Young Age – Cervical Artery Dissection (IPSYS CeAD) project is a multicenter, hospital-based, consecutively recruiting, observational, cohort study aimed to address clinically important questions about long-term outcome of CeAD patients, which are not covered by other large-scale registries. Patients with radiologically diagnosed CeAD were consecutively included in the registry. Baseline demographic and clinical variables, as well as information on risk factors, were systematically collected for each eligible patient. Follow-up evaluations were conducted between 3 and 6 months after the initial event (t1) and then annually (t2 at 1 year, t3 at 2 years , and so on), in order to assess outcome events (long-term recurrent CeAD, any fatal/nonfatal ischemic stroke, transient ischemic attack (TIA), or other arterial thrombotic event, and death from any cause). Between 2000 and 2019, data from 1530 patients (age at diagnosis, 47.2 ± 11.5 years; women, 660 [43.1%]) have been collected at 39 Italian neurological centers. Dissection involved a single vessel in 1308 (85.5%) cases and caused brain ischemia in 1303 (85.1%) (190 TIA/1113 ischemic stroke). Longitudinal data are available for 1414 (92.4%) patients (median follow-up time in patients who did not experience recurrent events, 36.0 months [25th to 75th percentile, 63.0]). The collaborative IPSYS CeAD effort will provide novel information on the long-term outcome of CeAD patients. This could allow for tailored treatment approaches based on patients’ individual characteristics. © 2020, Fondazione Società Italiana di Neurologia.
Original languageEnglish
Pages (from-to)3265-3272
Number of pages8
JournalNeurol. Sci.
Issue number11
Publication statusPublished - 2020


  • Cervical artery dissection
  • Outcome
  • Stroke in young adults
  • adult
  • artery dissection
  • Article
  • brain infarction
  • brain ischemia
  • cerebrovascular accident
  • cervical spine
  • clinical article
  • clinical feature
  • clinical outcome
  • cohort analysis
  • demography
  • disease free survival
  • evaluation study
  • female
  • follow up
  • human
  • internal carotid artery
  • Italy
  • lifestyle
  • longitudinal study
  • male
  • middle aged
  • mortality
  • multicenter study
  • observational study
  • onset age
  • outcome assessment
  • prognosis
  • recurrent disease
  • risk factor
  • subarachnoid hemorrhage
  • thrombosis
  • transient ischemic attack
  • vertebral artery


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