Long-term outcome of laparoscopic ablation therapies for unresectable hepatocellular carcinoma: a single European center experience of 426 patients

Roberto Santambrogio, Matteo Barabino, Savino Bruno, Mara Costa, Andrea Pisani Ceretti, Maria Rachele Angiolini, Massimo Zuin, Franca Meloni, Enrico Opocher

Research output: Contribution to journalArticle

Abstract

Background: Radiofrequency ablation (RFA) is widely used as a first-line option in patients with hepatocellular carcinoma (HCC). However, since percutaneous approach of RFA may be, in some cases, unfeasible by the tumor size and its location, laparoscopic ablation therapies (LATs) were used as an alternative. Objective of the present study was to assess the efficacy of laparoscopic ultrasound examination in addition to LATs in the treatment of HCC in patients not eligible for percutaneous RFA or surgical resection.Methods: Four hundred and twenty-six patients who underwent LATs were analyzed. Laparoscopic approach was offered to patients fulfilling at least one of the following criteria: (a) patients with a single nodule or up to three nodules smaller than 3 cm not suitable for liver transplantation or not eligible for HR because of severe portal hypertension, impaired liver function, or coexistent comorbidities; (b) patients not suitable for percutaneous RFA because of inconvenient tumor location; and (c) short-term recurrence of HCC (

Original languageEnglish
JournalSurgical Endoscopy and Other Interventional Techniques
DOIs
Publication statusAccepted/In press - Aug 15 2015

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Hepatocellular Carcinoma
Therapeutics
Portal Hypertension
Liver Transplantation
Comorbidity
Neoplasms
Recurrence
Liver

Keywords

  • Hepatocellular carcinoma
  • Laparoscopic ultrasound
  • Liver cirrhosis
  • Radiofrequency interstitial thermal ablation

ASJC Scopus subject areas

  • Surgery

Cite this

Long-term outcome of laparoscopic ablation therapies for unresectable hepatocellular carcinoma : a single European center experience of 426 patients. / Santambrogio, Roberto; Barabino, Matteo; Bruno, Savino; Costa, Mara; Ceretti, Andrea Pisani; Angiolini, Maria Rachele; Zuin, Massimo; Meloni, Franca; Opocher, Enrico.

In: Surgical Endoscopy and Other Interventional Techniques, 15.08.2015.

Research output: Contribution to journalArticle

Santambrogio, Roberto ; Barabino, Matteo ; Bruno, Savino ; Costa, Mara ; Ceretti, Andrea Pisani ; Angiolini, Maria Rachele ; Zuin, Massimo ; Meloni, Franca ; Opocher, Enrico. / Long-term outcome of laparoscopic ablation therapies for unresectable hepatocellular carcinoma : a single European center experience of 426 patients. In: Surgical Endoscopy and Other Interventional Techniques. 2015.
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AU - Costa, Mara

AU - Ceretti, Andrea Pisani

AU - Angiolini, Maria Rachele

AU - Zuin, Massimo

AU - Meloni, Franca

AU - Opocher, Enrico

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