Long-term outcomes following drug-eluting stent implantation in unprotected left main bifurcation lesions

Lei Ge, John Cosgrave, Ioannis Iakovou, Ju Ying Qian, Pierfrancesco Agostoni, Giuseppe M. Sangiorgi, Flavio Airoldi, Iassen Michev, Alaide Chieffo, Nicola Corvaja, Antonio Colombo, Jun Bo Ge

Research output: Contribution to journalArticle

Abstract

Background: The safety and efficacy of drug-eluting stents (DES) implantation in unprotected left main (LM) bifurcation lesions has yet to be determined. The aim of the present report was to evaluate the long-term outcome following implantation of DES in unprotected LM bifurcation lesions. Methods: We identified 70 consecutive patients treated with DES in unprotected LM bifurcation lesions from April 2003 to January 2005. Of them, 42 patients were treated with sirolimus-eluting stent (SES) and 28 patients were treated with paclitaxel-eluting stent (PES). Results: Stents to the left anterior descending and to the circumflex were implanted in 62 patients. During 1-year follow-up, 3 (4.3%) patients died of cardiac causes. One of them had myocardial infarction and adjudicated as possibly due to stent thrombosis. Angiographic follow-up was available in 80% of patients. The per lesion restenosis rate was 13.4% in the entire cohort, of which 10.7% occurred in lesions treated with SES and 16.1% in those treated with PES (P=0.58). All restenosis was focal and occurred in the lesions treated with a stent with stent size to post-procedural reference vessel diameter ratio

Original languageEnglish
Pages (from-to)545-551
Number of pages7
JournalChinese Medical Journal
Volume120
Issue number7
Publication statusPublished - Apr 5 2007

Keywords

  • Restenosis
  • Revascularization
  • Stents
  • Thrombosis

ASJC Scopus subject areas

  • Medicine(all)

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    Ge, L., Cosgrave, J., Iakovou, I., Qian, J. Y., Agostoni, P., Sangiorgi, G. M., Airoldi, F., Michev, I., Chieffo, A., Corvaja, N., Colombo, A., & Ge, J. B. (2007). Long-term outcomes following drug-eluting stent implantation in unprotected left main bifurcation lesions. Chinese Medical Journal, 120(7), 545-551.