Long-term outcomes of patients with cerebral vein thrombosis: A multicenter study

F. Dentali, D. Poli, U. Scoditti, M. N D di Minno, V. D. Stefano, S. Siragusa, M. Kostal, G. Palareti, M. T. Sartori, E. Grandone, M. C. Vedovati, W. Ageno, Anna Falanga, Teresa Lerede, Marina Bianchi, Sophie Testa, Dan Witt, Katie McCool, Eugenio Bucherini, Elisa GrifoniDaniela Coalizzo, Raffaella Benedetti, Marco Marietta, Maria Sessa, Clara Guaschino, Giovanni di Minno, Antonella Tufano, Sofia Barbar, Alessandra Malato, Mario Pini, Paola Castellini, Stefano Barco, Marisa Barone, Maurizio Paciaroni, Andrea Alberti, Giancarlo Agnelli, Matteo Giorgi Pierfranceschi, Petr Dulicek, Mauro Silingardi, Landini Federica, Angelo Ghirarduzzi, Eros Tiraferri, Vincenzo di Lazzaro, Elena Rossi, Angela Ciminello, Samantha Pasca, Giovanni Barillari, Emanuele Rezoagli, Matteo Galli, Alessandro Squizzato, Alberto Tosetto

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Background: Little information is available on the long-term clinical outcome of cerebral vein thrombosis (CVT). Objectives and methods: In an international, retrospective cohort study, we assessed the long-term rates of mortality, residual disability and recurrent venous thromboembolism (VTE) in a cohort of patients with a first CVT episode. Results: Seven hundred and six patients (73.7% females) with CVT were included. Patients were followed for a total of 3171 patient-years. Median follow-up was 40months (range 6, 297months). At the end of follow-up, 20 patients had died (2.8%). The outcome was generally good: 89.1% of patients had a complete recovery (modified Rankin Score [mRS] 0-1) and 3.8% had a partial recovery and were independent (mRS 2). Eighty-four per cent of patients were treated with oral anticoagulants and the mean treatment duration was 12months. CVT recurred in 31 patients (4.4%), and 46 patients (6.5%) had a VTE in a different site, for an overall incidence of recurrence of 23.6 events per 1000 patient-years (95% confidence Interval [CI] 17.8, 28.7) and of 35.1 events/1000 patient-years (95% CI, 27.7, 44.4) after anticoagulant therapy withdrawal. A previous VTE was the only significant predictor of recurrence at multivariate analysis (hazard ratio [HR] 2.70; 95% CI 1.25, 5.83). Conclusions: The long-term risk of mortality and recurrent VTE appears to be low in patients who survived the acute phase of CVT. A previous VTE history independently predicts recurrent events.

Original languageEnglish
Pages (from-to)1297-1302
Number of pages6
JournalJournal of Thrombosis and Haemostasis
Volume10
Issue number7
DOIs
Publication statusPublished - Jul 2012

Fingerprint

Cerebral Veins
Intracranial Thrombosis
Multicenter Studies
Venous Thromboembolism
Confidence Intervals
Anticoagulants
Recurrence
Mortality

Keywords

  • Anticoagulant treatment
  • Cerebral vein thrombosis
  • Mortality
  • Recurrence

ASJC Scopus subject areas

  • Hematology

Cite this

Dentali, F., Poli, D., Scoditti, U., di Minno, M. N. D., Stefano, V. D., Siragusa, S., ... Tosetto, A. (2012). Long-term outcomes of patients with cerebral vein thrombosis: A multicenter study. Journal of Thrombosis and Haemostasis, 10(7), 1297-1302. https://doi.org/10.1111/j.1538-7836.2012.04774.x

Long-term outcomes of patients with cerebral vein thrombosis : A multicenter study. / Dentali, F.; Poli, D.; Scoditti, U.; di Minno, M. N D; Stefano, V. D.; Siragusa, S.; Kostal, M.; Palareti, G.; Sartori, M. T.; Grandone, E.; Vedovati, M. C.; Ageno, W.; Falanga, Anna; Lerede, Teresa; Bianchi, Marina; Testa, Sophie; Witt, Dan; McCool, Katie; Bucherini, Eugenio; Grifoni, Elisa; Coalizzo, Daniela; Benedetti, Raffaella; Marietta, Marco; Sessa, Maria; Guaschino, Clara; di Minno, Giovanni; Tufano, Antonella; Barbar, Sofia; Malato, Alessandra; Pini, Mario; Castellini, Paola; Barco, Stefano; Barone, Marisa; Paciaroni, Maurizio; Alberti, Andrea; Agnelli, Giancarlo; Giorgi Pierfranceschi, Matteo; Dulicek, Petr; Silingardi, Mauro; Federica, Landini; Ghirarduzzi, Angelo; Tiraferri, Eros; di Lazzaro, Vincenzo; Rossi, Elena; Ciminello, Angela; Pasca, Samantha; Barillari, Giovanni; Rezoagli, Emanuele; Galli, Matteo; Squizzato, Alessandro; Tosetto, Alberto.

In: Journal of Thrombosis and Haemostasis, Vol. 10, No. 7, 07.2012, p. 1297-1302.

Research output: Contribution to journalArticle

Dentali, F, Poli, D, Scoditti, U, di Minno, MND, Stefano, VD, Siragusa, S, Kostal, M, Palareti, G, Sartori, MT, Grandone, E, Vedovati, MC, Ageno, W, Falanga, A, Lerede, T, Bianchi, M, Testa, S, Witt, D, McCool, K, Bucherini, E, Grifoni, E, Coalizzo, D, Benedetti, R, Marietta, M, Sessa, M, Guaschino, C, di Minno, G, Tufano, A, Barbar, S, Malato, A, Pini, M, Castellini, P, Barco, S, Barone, M, Paciaroni, M, Alberti, A, Agnelli, G, Giorgi Pierfranceschi, M, Dulicek, P, Silingardi, M, Federica, L, Ghirarduzzi, A, Tiraferri, E, di Lazzaro, V, Rossi, E, Ciminello, A, Pasca, S, Barillari, G, Rezoagli, E, Galli, M, Squizzato, A & Tosetto, A 2012, 'Long-term outcomes of patients with cerebral vein thrombosis: A multicenter study', Journal of Thrombosis and Haemostasis, vol. 10, no. 7, pp. 1297-1302. https://doi.org/10.1111/j.1538-7836.2012.04774.x
Dentali, F. ; Poli, D. ; Scoditti, U. ; di Minno, M. N D ; Stefano, V. D. ; Siragusa, S. ; Kostal, M. ; Palareti, G. ; Sartori, M. T. ; Grandone, E. ; Vedovati, M. C. ; Ageno, W. ; Falanga, Anna ; Lerede, Teresa ; Bianchi, Marina ; Testa, Sophie ; Witt, Dan ; McCool, Katie ; Bucherini, Eugenio ; Grifoni, Elisa ; Coalizzo, Daniela ; Benedetti, Raffaella ; Marietta, Marco ; Sessa, Maria ; Guaschino, Clara ; di Minno, Giovanni ; Tufano, Antonella ; Barbar, Sofia ; Malato, Alessandra ; Pini, Mario ; Castellini, Paola ; Barco, Stefano ; Barone, Marisa ; Paciaroni, Maurizio ; Alberti, Andrea ; Agnelli, Giancarlo ; Giorgi Pierfranceschi, Matteo ; Dulicek, Petr ; Silingardi, Mauro ; Federica, Landini ; Ghirarduzzi, Angelo ; Tiraferri, Eros ; di Lazzaro, Vincenzo ; Rossi, Elena ; Ciminello, Angela ; Pasca, Samantha ; Barillari, Giovanni ; Rezoagli, Emanuele ; Galli, Matteo ; Squizzato, Alessandro ; Tosetto, Alberto. / Long-term outcomes of patients with cerebral vein thrombosis : A multicenter study. In: Journal of Thrombosis and Haemostasis. 2012 ; Vol. 10, No. 7. pp. 1297-1302.
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abstract = "Background: Little information is available on the long-term clinical outcome of cerebral vein thrombosis (CVT). Objectives and methods: In an international, retrospective cohort study, we assessed the long-term rates of mortality, residual disability and recurrent venous thromboembolism (VTE) in a cohort of patients with a first CVT episode. Results: Seven hundred and six patients (73.7{\%} females) with CVT were included. Patients were followed for a total of 3171 patient-years. Median follow-up was 40months (range 6, 297months). At the end of follow-up, 20 patients had died (2.8{\%}). The outcome was generally good: 89.1{\%} of patients had a complete recovery (modified Rankin Score [mRS] 0-1) and 3.8{\%} had a partial recovery and were independent (mRS 2). Eighty-four per cent of patients were treated with oral anticoagulants and the mean treatment duration was 12months. CVT recurred in 31 patients (4.4{\%}), and 46 patients (6.5{\%}) had a VTE in a different site, for an overall incidence of recurrence of 23.6 events per 1000 patient-years (95{\%} confidence Interval [CI] 17.8, 28.7) and of 35.1 events/1000 patient-years (95{\%} CI, 27.7, 44.4) after anticoagulant therapy withdrawal. A previous VTE was the only significant predictor of recurrence at multivariate analysis (hazard ratio [HR] 2.70; 95{\%} CI 1.25, 5.83). Conclusions: The long-term risk of mortality and recurrent VTE appears to be low in patients who survived the acute phase of CVT. A previous VTE history independently predicts recurrent events.",
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TY - JOUR

T1 - Long-term outcomes of patients with cerebral vein thrombosis

T2 - A multicenter study

AU - Dentali, F.

AU - Poli, D.

AU - Scoditti, U.

AU - di Minno, M. N D

AU - Stefano, V. D.

AU - Siragusa, S.

AU - Kostal, M.

AU - Palareti, G.

AU - Sartori, M. T.

AU - Grandone, E.

AU - Vedovati, M. C.

AU - Ageno, W.

AU - Falanga, Anna

AU - Lerede, Teresa

AU - Bianchi, Marina

AU - Testa, Sophie

AU - Witt, Dan

AU - McCool, Katie

AU - Bucherini, Eugenio

AU - Grifoni, Elisa

AU - Coalizzo, Daniela

AU - Benedetti, Raffaella

AU - Marietta, Marco

AU - Sessa, Maria

AU - Guaschino, Clara

AU - di Minno, Giovanni

AU - Tufano, Antonella

AU - Barbar, Sofia

AU - Malato, Alessandra

AU - Pini, Mario

AU - Castellini, Paola

AU - Barco, Stefano

AU - Barone, Marisa

AU - Paciaroni, Maurizio

AU - Alberti, Andrea

AU - Agnelli, Giancarlo

AU - Giorgi Pierfranceschi, Matteo

AU - Dulicek, Petr

AU - Silingardi, Mauro

AU - Federica, Landini

AU - Ghirarduzzi, Angelo

AU - Tiraferri, Eros

AU - di Lazzaro, Vincenzo

AU - Rossi, Elena

AU - Ciminello, Angela

AU - Pasca, Samantha

AU - Barillari, Giovanni

AU - Rezoagli, Emanuele

AU - Galli, Matteo

AU - Squizzato, Alessandro

AU - Tosetto, Alberto

PY - 2012/7

Y1 - 2012/7

N2 - Background: Little information is available on the long-term clinical outcome of cerebral vein thrombosis (CVT). Objectives and methods: In an international, retrospective cohort study, we assessed the long-term rates of mortality, residual disability and recurrent venous thromboembolism (VTE) in a cohort of patients with a first CVT episode. Results: Seven hundred and six patients (73.7% females) with CVT were included. Patients were followed for a total of 3171 patient-years. Median follow-up was 40months (range 6, 297months). At the end of follow-up, 20 patients had died (2.8%). The outcome was generally good: 89.1% of patients had a complete recovery (modified Rankin Score [mRS] 0-1) and 3.8% had a partial recovery and were independent (mRS 2). Eighty-four per cent of patients were treated with oral anticoagulants and the mean treatment duration was 12months. CVT recurred in 31 patients (4.4%), and 46 patients (6.5%) had a VTE in a different site, for an overall incidence of recurrence of 23.6 events per 1000 patient-years (95% confidence Interval [CI] 17.8, 28.7) and of 35.1 events/1000 patient-years (95% CI, 27.7, 44.4) after anticoagulant therapy withdrawal. A previous VTE was the only significant predictor of recurrence at multivariate analysis (hazard ratio [HR] 2.70; 95% CI 1.25, 5.83). Conclusions: The long-term risk of mortality and recurrent VTE appears to be low in patients who survived the acute phase of CVT. A previous VTE history independently predicts recurrent events.

AB - Background: Little information is available on the long-term clinical outcome of cerebral vein thrombosis (CVT). Objectives and methods: In an international, retrospective cohort study, we assessed the long-term rates of mortality, residual disability and recurrent venous thromboembolism (VTE) in a cohort of patients with a first CVT episode. Results: Seven hundred and six patients (73.7% females) with CVT were included. Patients were followed for a total of 3171 patient-years. Median follow-up was 40months (range 6, 297months). At the end of follow-up, 20 patients had died (2.8%). The outcome was generally good: 89.1% of patients had a complete recovery (modified Rankin Score [mRS] 0-1) and 3.8% had a partial recovery and were independent (mRS 2). Eighty-four per cent of patients were treated with oral anticoagulants and the mean treatment duration was 12months. CVT recurred in 31 patients (4.4%), and 46 patients (6.5%) had a VTE in a different site, for an overall incidence of recurrence of 23.6 events per 1000 patient-years (95% confidence Interval [CI] 17.8, 28.7) and of 35.1 events/1000 patient-years (95% CI, 27.7, 44.4) after anticoagulant therapy withdrawal. A previous VTE was the only significant predictor of recurrence at multivariate analysis (hazard ratio [HR] 2.70; 95% CI 1.25, 5.83). Conclusions: The long-term risk of mortality and recurrent VTE appears to be low in patients who survived the acute phase of CVT. A previous VTE history independently predicts recurrent events.

KW - Anticoagulant treatment

KW - Cerebral vein thrombosis

KW - Mortality

KW - Recurrence

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