Long-term outcomes of patients with intraductal growth sub-type of intrahepatic cholangiocarcinoma

F Bagante, M Weiss, S Alexandrescu, HP Marques, L Aldrighetti, SK Maithel, C Pulitano, TW Bauer, F Shen, GA Poultsides, O Soubrane, G Martel, BG Koerkamp, A Guglielmi, E Itaru, TM Pawlik

Research output: Contribution to journalArticle

Abstract

Background: Intraductal-growth (IG) type of intrahepatic cholangiocarcinoma (ICC) may be associated with a favorable prognosis compared with mass-forming (MF) and periductal-infiltrating (PI) ICC. Methods: The clinico-pathological characteristics and long-term outcomes of 1206 patients undergoing liver resection for ICC were compared based on the ICC morphological classification. Results: Compared with MF patients, IG patients had a higher incidence of poor/un-differentiated tumor, lympho-vascular, and perineural invasion (poor/un-differentiated: MF, 18% vs. IG, 24%; lympho-vascular invasion: MF, 30% vs. IG, 35%; perineural invasion: MF, 17% vs. IG, 33%; all p > 0.05). The pattern of recurrence was different among MF patients (intrahepatic only: 63%; extrahepatic only: 22%; both intra- and extrahepatic: 16%) versus IG patients (intrahepatic only: 46%; extrahepatic: 25%; both intra- and extrahepatic: 29%) (p <0.001). Moreover, while 78% of patients with MF had an early recurrence (
Original languageEnglish
Pages (from-to)1189-1197
Number of pages9
JournalHPB
Volume20
Issue number12
DOIs
Publication statusPublished - 2018

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Cholangiocarcinoma
Growth
Blood Vessels
Recurrence
Liver
Incidence
Neoplasms

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Bagante, F., Weiss, M., Alexandrescu, S., Marques, HP., Aldrighetti, L., Maithel, SK., ... Pawlik, TM. (2018). Long-term outcomes of patients with intraductal growth sub-type of intrahepatic cholangiocarcinoma. HPB, 20(12), 1189-1197. https://doi.org/10.1016/j.hpb.2018.05.017

Long-term outcomes of patients with intraductal growth sub-type of intrahepatic cholangiocarcinoma. / Bagante, F; Weiss, M; Alexandrescu, S; Marques, HP; Aldrighetti, L; Maithel, SK; Pulitano, C; Bauer, TW; Shen, F; Poultsides, GA; Soubrane, O; Martel, G; Koerkamp, BG; Guglielmi, A; Itaru, E; Pawlik, TM.

In: HPB, Vol. 20, No. 12, 2018, p. 1189-1197.

Research output: Contribution to journalArticle

Bagante, F, Weiss, M, Alexandrescu, S, Marques, HP, Aldrighetti, L, Maithel, SK, Pulitano, C, Bauer, TW, Shen, F, Poultsides, GA, Soubrane, O, Martel, G, Koerkamp, BG, Guglielmi, A, Itaru, E & Pawlik, TM 2018, 'Long-term outcomes of patients with intraductal growth sub-type of intrahepatic cholangiocarcinoma', HPB, vol. 20, no. 12, pp. 1189-1197. https://doi.org/10.1016/j.hpb.2018.05.017
Bagante, F ; Weiss, M ; Alexandrescu, S ; Marques, HP ; Aldrighetti, L ; Maithel, SK ; Pulitano, C ; Bauer, TW ; Shen, F ; Poultsides, GA ; Soubrane, O ; Martel, G ; Koerkamp, BG ; Guglielmi, A ; Itaru, E ; Pawlik, TM. / Long-term outcomes of patients with intraductal growth sub-type of intrahepatic cholangiocarcinoma. In: HPB. 2018 ; Vol. 20, No. 12. pp. 1189-1197.
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T1 - Long-term outcomes of patients with intraductal growth sub-type of intrahepatic cholangiocarcinoma

AU - Bagante, F

AU - Weiss, M

AU - Alexandrescu, S

AU - Marques, HP

AU - Aldrighetti, L

AU - Maithel, SK

AU - Pulitano, C

AU - Bauer, TW

AU - Shen, F

AU - Poultsides, GA

AU - Soubrane, O

AU - Martel, G

AU - Koerkamp, BG

AU - Guglielmi, A

AU - Itaru, E

AU - Pawlik, TM

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N2 - Background: Intraductal-growth (IG) type of intrahepatic cholangiocarcinoma (ICC) may be associated with a favorable prognosis compared with mass-forming (MF) and periductal-infiltrating (PI) ICC. Methods: The clinico-pathological characteristics and long-term outcomes of 1206 patients undergoing liver resection for ICC were compared based on the ICC morphological classification. Results: Compared with MF patients, IG patients had a higher incidence of poor/un-differentiated tumor, lympho-vascular, and perineural invasion (poor/un-differentiated: MF, 18% vs. IG, 24%; lympho-vascular invasion: MF, 30% vs. IG, 35%; perineural invasion: MF, 17% vs. IG, 33%; all p > 0.05). The pattern of recurrence was different among MF patients (intrahepatic only: 63%; extrahepatic only: 22%; both intra- and extrahepatic: 16%) versus IG patients (intrahepatic only: 46%; extrahepatic: 25%; both intra- and extrahepatic: 29%) (p <0.001). Moreover, while 78% of patients with MF had an early recurrence (

AB - Background: Intraductal-growth (IG) type of intrahepatic cholangiocarcinoma (ICC) may be associated with a favorable prognosis compared with mass-forming (MF) and periductal-infiltrating (PI) ICC. Methods: The clinico-pathological characteristics and long-term outcomes of 1206 patients undergoing liver resection for ICC were compared based on the ICC morphological classification. Results: Compared with MF patients, IG patients had a higher incidence of poor/un-differentiated tumor, lympho-vascular, and perineural invasion (poor/un-differentiated: MF, 18% vs. IG, 24%; lympho-vascular invasion: MF, 30% vs. IG, 35%; perineural invasion: MF, 17% vs. IG, 33%; all p > 0.05). The pattern of recurrence was different among MF patients (intrahepatic only: 63%; extrahepatic only: 22%; both intra- and extrahepatic: 16%) versus IG patients (intrahepatic only: 46%; extrahepatic: 25%; both intra- and extrahepatic: 29%) (p <0.001). Moreover, while 78% of patients with MF had an early recurrence (

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