Long-term outcomes of patients with intraductal growth sub-type of intrahepatic cholangiocarcinoma

F Bagante; M Weiss; S Alexandrescu; HP Marques; L Aldrighetti; SK Maithel; C Pulitano; TW Bauer; F Shen; GA Poultsides; O Soubrane; G Martel; BG Koerkamp; A Guglielmi; E Itaru; TM Pawlik

doi:10.1016/j.hpb.2018.05.017

Long-term outcomes of patients with intraductal growth sub-type of intrahepatic cholangiocarcinoma

F Bagante, M Weiss, S Alexandrescu, HP Marques, L Aldrighetti, SK Maithel, C Pulitano, TW Bauer, F Shen, GA Poultsides, O Soubrane, G Martel, BG Koerkamp, A Guglielmi, E Itaru, TM Pawlik

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Intraductal-growth (IG) type of intrahepatic cholangiocarcinoma (ICC) may be associated with a favorable prognosis compared with mass-forming (MF) and periductal-infiltrating (PI) ICC. Methods: The clinico-pathological characteristics and long-term outcomes of 1206 patients undergoing liver resection for ICC were compared based on the ICC morphological classification. Results: Compared with MF patients, IG patients had a higher incidence of poor/un-differentiated tumor, lympho-vascular, and perineural invasion (poor/un-differentiated: MF, 18% vs. IG, 24%; lympho-vascular invasion: MF, 30% vs. IG, 35%; perineural invasion: MF, 17% vs. IG, 33%; all p > 0.05). The pattern of recurrence was different among MF patients (intrahepatic only: 63%; extrahepatic only: 22%; both intra- and extrahepatic: 16%) versus IG patients (intrahepatic only: 46%; extrahepatic: 25%; both intra- and extrahepatic: 29%) (p <0.001). Moreover, while 78% of patients with MF had an early recurrence (

Original language	English
Pages (from-to)	1189-1197
Number of pages	9
Journal	HPB
Volume	20
Issue number	12
DOIs	https://doi.org/10.1016/j.hpb.2018.05.017
Publication status	Published - 2018

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Bagante, F., Weiss, M., Alexandrescu, S., Marques, HP., Aldrighetti, L., Maithel, SK., Pulitano, C., Bauer, TW., Shen, F., Poultsides, GA., Soubrane, O., Martel, G., Koerkamp, BG., Guglielmi, A., Itaru, E., & Pawlik, TM. (2018). Long-term outcomes of patients with intraductal growth sub-type of intrahepatic cholangiocarcinoma. HPB, 20(12), 1189-1197. https://doi.org/10.1016/j.hpb.2018.05.017

Long-term outcomes of patients with intraductal growth sub-type of intrahepatic cholangiocarcinoma. / Bagante, F; Weiss, M; Alexandrescu, S; Marques, HP; Aldrighetti, L; Maithel, SK; Pulitano, C; Bauer, TW; Shen, F; Poultsides, GA; Soubrane, O; Martel, G; Koerkamp, BG; Guglielmi, A; Itaru, E; Pawlik, TM.

In: HPB, Vol. 20, No. 12, 2018, p. 1189-1197.

Research output: Contribution to journal › Article › peer-review

Bagante, F, Weiss, M, Alexandrescu, S, Marques, HP, Aldrighetti, L, Maithel, SK, Pulitano, C, Bauer, TW, Shen, F, Poultsides, GA, Soubrane, O, Martel, G, Koerkamp, BG, Guglielmi, A, Itaru, E & Pawlik, TM 2018, 'Long-term outcomes of patients with intraductal growth sub-type of intrahepatic cholangiocarcinoma', HPB, vol. 20, no. 12, pp. 1189-1197. https://doi.org/10.1016/j.hpb.2018.05.017

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title = "Long-term outcomes of patients with intraductal growth sub-type of intrahepatic cholangiocarcinoma",

abstract = "Background: Intraductal-growth (IG) type of intrahepatic cholangiocarcinoma (ICC) may be associated with a favorable prognosis compared with mass-forming (MF) and periductal-infiltrating (PI) ICC. Methods: The clinico-pathological characteristics and long-term outcomes of 1206 patients undergoing liver resection for ICC were compared based on the ICC morphological classification. Results: Compared with MF patients, IG patients had a higher incidence of poor/un-differentiated tumor, lympho-vascular, and perineural invasion (poor/un-differentiated: MF, 18% vs. IG, 24%; lympho-vascular invasion: MF, 30% vs. IG, 35%; perineural invasion: MF, 17% vs. IG, 33%; all p > 0.05). The pattern of recurrence was different among MF patients (intrahepatic only: 63%; extrahepatic only: 22%; both intra- and extrahepatic: 16%) versus IG patients (intrahepatic only: 46%; extrahepatic: 25%; both intra- and extrahepatic: 29%) (p <0.001). Moreover, while 78% of patients with MF had an early recurrence (",

author = "F Bagante and M Weiss and S Alexandrescu and HP Marques and L Aldrighetti and SK Maithel and C Pulitano and TW Bauer and F Shen and GA Poultsides and O Soubrane and G Martel and BG Koerkamp and A Guglielmi and E Itaru and TM Pawlik",

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T1 - Long-term outcomes of patients with intraductal growth sub-type of intrahepatic cholangiocarcinoma

AU - Bagante, F

AU - Weiss, M

AU - Alexandrescu, S

AU - Marques, HP

AU - Aldrighetti, L

AU - Maithel, SK

AU - Pulitano, C

AU - Bauer, TW

AU - Shen, F

AU - Poultsides, GA

AU - Soubrane, O

AU - Martel, G

AU - Koerkamp, BG

AU - Guglielmi, A

AU - Itaru, E

AU - Pawlik, TM

PY - 2018

Y1 - 2018

N2 - Background: Intraductal-growth (IG) type of intrahepatic cholangiocarcinoma (ICC) may be associated with a favorable prognosis compared with mass-forming (MF) and periductal-infiltrating (PI) ICC. Methods: The clinico-pathological characteristics and long-term outcomes of 1206 patients undergoing liver resection for ICC were compared based on the ICC morphological classification. Results: Compared with MF patients, IG patients had a higher incidence of poor/un-differentiated tumor, lympho-vascular, and perineural invasion (poor/un-differentiated: MF, 18% vs. IG, 24%; lympho-vascular invasion: MF, 30% vs. IG, 35%; perineural invasion: MF, 17% vs. IG, 33%; all p > 0.05). The pattern of recurrence was different among MF patients (intrahepatic only: 63%; extrahepatic only: 22%; both intra- and extrahepatic: 16%) versus IG patients (intrahepatic only: 46%; extrahepatic: 25%; both intra- and extrahepatic: 29%) (p <0.001). Moreover, while 78% of patients with MF had an early recurrence (

AB - Background: Intraductal-growth (IG) type of intrahepatic cholangiocarcinoma (ICC) may be associated with a favorable prognosis compared with mass-forming (MF) and periductal-infiltrating (PI) ICC. Methods: The clinico-pathological characteristics and long-term outcomes of 1206 patients undergoing liver resection for ICC were compared based on the ICC morphological classification. Results: Compared with MF patients, IG patients had a higher incidence of poor/un-differentiated tumor, lympho-vascular, and perineural invasion (poor/un-differentiated: MF, 18% vs. IG, 24%; lympho-vascular invasion: MF, 30% vs. IG, 35%; perineural invasion: MF, 17% vs. IG, 33%; all p > 0.05). The pattern of recurrence was different among MF patients (intrahepatic only: 63%; extrahepatic only: 22%; both intra- and extrahepatic: 16%) versus IG patients (intrahepatic only: 46%; extrahepatic: 25%; both intra- and extrahepatic: 29%) (p <0.001). Moreover, while 78% of patients with MF had an early recurrence (

U2 - 10.1016/j.hpb.2018.05.017

DO - 10.1016/j.hpb.2018.05.017

M3 - Article

VL - 20

SP - 1189

EP - 1197

JO - HPB

JF - HPB

SN - 1365-182X

IS - 12

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