Long-term outcomes of patients with intraductal growth sub-type of intrahepatic cholangiocarcinoma

F Bagante, M Weiss, S Alexandrescu, HP Marques, L Aldrighetti, SK Maithel, C Pulitano, TW Bauer, F Shen, GA Poultsides, O Soubrane, G Martel, BG Koerkamp, A Guglielmi, E Itaru, TM Pawlik

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Background: Intraductal-growth (IG) type of intrahepatic cholangiocarcinoma (ICC) may be associated with a favorable prognosis compared with mass-forming (MF) and periductal-infiltrating (PI) ICC. Methods: The clinico-pathological characteristics and long-term outcomes of 1206 patients undergoing liver resection for ICC were compared based on the ICC morphological classification. Results: Compared with MF patients, IG patients had a higher incidence of poor/un-differentiated tumor, lympho-vascular, and perineural invasion (poor/un-differentiated: MF, 18% vs. IG, 24%; lympho-vascular invasion: MF, 30% vs. IG, 35%; perineural invasion: MF, 17% vs. IG, 33%; all p > 0.05). The pattern of recurrence was different among MF patients (intrahepatic only: 63%; extrahepatic only: 22%; both intra- and extrahepatic: 16%) versus IG patients (intrahepatic only: 46%; extrahepatic: 25%; both intra- and extrahepatic: 29%) (p <0.001). Moreover, while 78% of patients with MF had an early recurrence (
Original languageEnglish
Pages (from-to)1189-1197
Number of pages9
Issue number12
Publication statusPublished - 2018


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