Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 1189-1197 |
| Number of pages | 9 |
| Journal | HPB |
| Volume | 20 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 2018 |
Fingerprint
Cite this
Long-term outcomes of patients with intraductal growth sub-type of intrahepatic cholangiocarcinoma. / Bagante, F; Weiss, M; Alexandrescu, S; Marques, HP; Aldrighetti, L; Maithel, SK; Pulitano, C; Bauer, TW; Shen, F; Poultsides, GA; Soubrane, O; Martel, G; Koerkamp, BG; Guglielmi, A; Itaru, E; Pawlik, TM.
In: HPB, Vol. 20, No. 12, 2018, p. 1189-1197.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Long-term outcomes of patients with intraductal growth sub-type of intrahepatic cholangiocarcinoma
AU - Bagante, F
AU - Weiss, M
AU - Alexandrescu, S
AU - Marques, HP
AU - Aldrighetti, L
AU - Maithel, SK
AU - Pulitano, C
AU - Bauer, TW
AU - Shen, F
AU - Poultsides, GA
AU - Soubrane, O
AU - Martel, G
AU - Koerkamp, BG
AU - Guglielmi, A
AU - Itaru, E
AU - Pawlik, TM
PY - 2018
Y1 - 2018
N2 - Background: Intraductal-growth (IG) type of intrahepatic cholangiocarcinoma (ICC) may be associated with a favorable prognosis compared with mass-forming (MF) and periductal-infiltrating (PI) ICC. Methods: The clinico-pathological characteristics and long-term outcomes of 1206 patients undergoing liver resection for ICC were compared based on the ICC morphological classification. Results: Compared with MF patients, IG patients had a higher incidence of poor/un-differentiated tumor, lympho-vascular, and perineural invasion (poor/un-differentiated: MF, 18% vs. IG, 24%; lympho-vascular invasion: MF, 30% vs. IG, 35%; perineural invasion: MF, 17% vs. IG, 33%; all p > 0.05). The pattern of recurrence was different among MF patients (intrahepatic only: 63%; extrahepatic only: 22%; both intra- and extrahepatic: 16%) versus IG patients (intrahepatic only: 46%; extrahepatic: 25%; both intra- and extrahepatic: 29%) (p <0.001). Moreover, while 78% of patients with MF had an early recurrence (
AB - Background: Intraductal-growth (IG) type of intrahepatic cholangiocarcinoma (ICC) may be associated with a favorable prognosis compared with mass-forming (MF) and periductal-infiltrating (PI) ICC. Methods: The clinico-pathological characteristics and long-term outcomes of 1206 patients undergoing liver resection for ICC were compared based on the ICC morphological classification. Results: Compared with MF patients, IG patients had a higher incidence of poor/un-differentiated tumor, lympho-vascular, and perineural invasion (poor/un-differentiated: MF, 18% vs. IG, 24%; lympho-vascular invasion: MF, 30% vs. IG, 35%; perineural invasion: MF, 17% vs. IG, 33%; all p > 0.05). The pattern of recurrence was different among MF patients (intrahepatic only: 63%; extrahepatic only: 22%; both intra- and extrahepatic: 16%) versus IG patients (intrahepatic only: 46%; extrahepatic: 25%; both intra- and extrahepatic: 29%) (p <0.001). Moreover, while 78% of patients with MF had an early recurrence (
U2 - 10.1016/j.hpb.2018.05.017
DO - 10.1016/j.hpb.2018.05.017
M3 - Article
VL - 20
SP - 1189
EP - 1197
JO - HPB
JF - HPB
SN - 1365-182X
IS - 12
ER -