Long-term perfusion of isolated rat liver

I. Bartošek, A. Guaitani, S. Garattini

Research output: Contribution to journalArticlepeer-review


During an 8-hour perfusion of isolated rat liver the following phenomena were studied: Kinetic blood levels of glucose, urea and potassium, activity of glutamic-oxalacetic and glutamic-pyruvic transaminases and alkaline phosphatase, hemolysis, bile production and endohepatic blood pressure. The effects of sterile and non-sterile conditions of perfusion, dialysis and infusion of nicotinic acid on these parameters were observed. A simple and versatile apparatus for long-term liver perfusion of small laboratory animals is described.

Original languageEnglish
Pages (from-to)244-258
Number of pages15
Issue number4-6
Publication statusPublished - 1972


  • Bile
  • Dialysis
  • Enzymes
  • Glucose
  • Infusion of nicotinic acid
  • Liver perfusion
  • Potassium rat
  • Sterility
  • Urea

ASJC Scopus subject areas

  • Pharmacology


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