Long-term preclinical magnetic resonance imaging alterations in sporadic Creutzfeldt–Jakob disease

Gianluigi Zanusso, Giulia Camporese, Sergio Ferrari, Luca Santelli, Matilde Bongianni, Michele Fiorini, Salvatore Monaco, Renzo Manara, Annachiara Cagnin

Research output: Contribution to journalArticle

Abstract

An asymptomatic 74-year-old woman, on follow-up for a carotid body tumor, showed magnetic resonance imaging (MRI) focal restricted diffusion confined to the left temporal and occipital cortices. Thirteen months later, diffusion-weighted images revealed a bilateral cortical ribbon sign involving all lobes. After 1 month, the patient developed gait instability and cognitive decline rapidly evolving to severe dementia and death within 3 months. Prion protein gene sequence, molecular, and neuropathological studies confirmed the diagnosis of sporadic Creutzfeldt–Jakob disease (sCJD) MM1 subtype. Here we show the kinetics of MRI changes and prion spreading in preclinical sCJD MM1. Ann Neurol 2016;80:629–632.

Original languageEnglish
Pages (from-to)629-632
Number of pages4
JournalAnnals of Neurology
Volume80
Issue number4
DOIs
Publication statusPublished - Oct 1 2016

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Magnetic Resonance Imaging
Carotid Body Tumor
Occipital Lobe
Prions
Temporal Lobe
Gait
Dementia
Genes
Cognitive Dysfunction
Prion Proteins

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Zanusso, G., Camporese, G., Ferrari, S., Santelli, L., Bongianni, M., Fiorini, M., ... Cagnin, A. (2016). Long-term preclinical magnetic resonance imaging alterations in sporadic Creutzfeldt–Jakob disease. Annals of Neurology, 80(4), 629-632. https://doi.org/10.1002/ana.24757

Long-term preclinical magnetic resonance imaging alterations in sporadic Creutzfeldt–Jakob disease. / Zanusso, Gianluigi; Camporese, Giulia; Ferrari, Sergio; Santelli, Luca; Bongianni, Matilde; Fiorini, Michele; Monaco, Salvatore; Manara, Renzo; Cagnin, Annachiara.

In: Annals of Neurology, Vol. 80, No. 4, 01.10.2016, p. 629-632.

Research output: Contribution to journalArticle

Zanusso, G, Camporese, G, Ferrari, S, Santelli, L, Bongianni, M, Fiorini, M, Monaco, S, Manara, R & Cagnin, A 2016, 'Long-term preclinical magnetic resonance imaging alterations in sporadic Creutzfeldt–Jakob disease', Annals of Neurology, vol. 80, no. 4, pp. 629-632. https://doi.org/10.1002/ana.24757
Zanusso G, Camporese G, Ferrari S, Santelli L, Bongianni M, Fiorini M et al. Long-term preclinical magnetic resonance imaging alterations in sporadic Creutzfeldt–Jakob disease. Annals of Neurology. 2016 Oct 1;80(4):629-632. https://doi.org/10.1002/ana.24757
Zanusso, Gianluigi ; Camporese, Giulia ; Ferrari, Sergio ; Santelli, Luca ; Bongianni, Matilde ; Fiorini, Michele ; Monaco, Salvatore ; Manara, Renzo ; Cagnin, Annachiara. / Long-term preclinical magnetic resonance imaging alterations in sporadic Creutzfeldt–Jakob disease. In: Annals of Neurology. 2016 ; Vol. 80, No. 4. pp. 629-632.
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