Long-term preclinical magnetic resonance imaging alterations in sporadic Creutzfeldt–Jakob disease

Gianluigi Zanusso; Giulia Camporese; Sergio Ferrari; Luca Santelli; Matilde Bongianni; Michele Fiorini; Salvatore Monaco; Renzo Manara; Annachiara Cagnin

doi:10.1002/ana.24757

Long-term preclinical magnetic resonance imaging alterations in sporadic Creutzfeldt–Jakob disease

Gianluigi Zanusso, Giulia Camporese, Sergio Ferrari, Luca Santelli, Matilde Bongianni, Michele Fiorini, Salvatore Monaco, Renzo Manara, Annachiara Cagnin

Istituto di Neuroriabilitazione Motoria San Camillo

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Abstract

An asymptomatic 74-year-old woman, on follow-up for a carotid body tumor, showed magnetic resonance imaging (MRI) focal restricted diffusion confined to the left temporal and occipital cortices. Thirteen months later, diffusion-weighted images revealed a bilateral cortical ribbon sign involving all lobes. After 1 month, the patient developed gait instability and cognitive decline rapidly evolving to severe dementia and death within 3 months. Prion protein gene sequence, molecular, and neuropathological studies confirmed the diagnosis of sporadic Creutzfeldt–Jakob disease (sCJD) MM1 subtype. Here we show the kinetics of MRI changes and prion spreading in preclinical sCJD MM1. Ann Neurol 2016;80:629–632.

Original language	English
Pages (from-to)	629-632
Number of pages	4
Journal	Annals of Neurology
Volume	80
Issue number	4
DOIs	https://doi.org/10.1002/ana.24757
Publication status	Published - Oct 1 2016

ASJC Scopus subject areas

Neurology
Clinical Neurology

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Long-term preclinical magnetic resonance imaging alterations in sporadic Creutzfeldt–Jakob disease. / Zanusso, Gianluigi; Camporese, Giulia; Ferrari, Sergio; Santelli, Luca; Bongianni, Matilde; Fiorini, Michele; Monaco, Salvatore; Manara, Renzo; Cagnin, Annachiara.

In: Annals of Neurology, Vol. 80, No. 4, 01.10.2016, p. 629-632.

Research output: Contribution to journal › Article › peer-review

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abstract = "An asymptomatic 74-year-old woman, on follow-up for a carotid body tumor, showed magnetic resonance imaging (MRI) focal restricted diffusion confined to the left temporal and occipital cortices. Thirteen months later, diffusion-weighted images revealed a bilateral cortical ribbon sign involving all lobes. After 1 month, the patient developed gait instability and cognitive decline rapidly evolving to severe dementia and death within 3 months. Prion protein gene sequence, molecular, and neuropathological studies confirmed the diagnosis of sporadic Creutzfeldt–Jakob disease (sCJD) MM1 subtype. Here we show the kinetics of MRI changes and prion spreading in preclinical sCJD MM1. Ann Neurol 2016;80:629–632.",

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AU - Ferrari, Sergio

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AU - Bongianni, Matilde

AU - Fiorini, Michele

AU - Monaco, Salvatore

AU - Manara, Renzo

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Long-term preclinical magnetic resonance imaging alterations in sporadic Creutzfeldt–Jakob disease

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