Abstract
An asymptomatic 74-year-old woman, on follow-up for a carotid body tumor, showed magnetic resonance imaging (MRI) focal restricted diffusion confined to the left temporal and occipital cortices. Thirteen months later, diffusion-weighted images revealed a bilateral cortical ribbon sign involving all lobes. After 1 month, the patient developed gait instability and cognitive decline rapidly evolving to severe dementia and death within 3 months. Prion protein gene sequence, molecular, and neuropathological studies confirmed the diagnosis of sporadic Creutzfeldt–Jakob disease (sCJD) MM1 subtype. Here we show the kinetics of MRI changes and prion spreading in preclinical sCJD MM1. Ann Neurol 2016;80:629–632.
| Original language | English |
|---|---|
| Pages (from-to) | 629-632 |
| Number of pages | 4 |
| Journal | Annals of Neurology |
| Volume | 80 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Oct 1 2016 |
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ASJC Scopus subject areas
- Neurology
- Clinical Neurology
Cite this
Long-term preclinical magnetic resonance imaging alterations in sporadic Creutzfeldt–Jakob disease. / Zanusso, Gianluigi; Camporese, Giulia; Ferrari, Sergio; Santelli, Luca; Bongianni, Matilde; Fiorini, Michele; Monaco, Salvatore; Manara, Renzo; Cagnin, Annachiara.
In: Annals of Neurology, Vol. 80, No. 4, 01.10.2016, p. 629-632.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Long-term preclinical magnetic resonance imaging alterations in sporadic Creutzfeldt–Jakob disease
AU - Zanusso, Gianluigi
AU - Camporese, Giulia
AU - Ferrari, Sergio
AU - Santelli, Luca
AU - Bongianni, Matilde
AU - Fiorini, Michele
AU - Monaco, Salvatore
AU - Manara, Renzo
AU - Cagnin, Annachiara
PY - 2016/10/1
Y1 - 2016/10/1
N2 - An asymptomatic 74-year-old woman, on follow-up for a carotid body tumor, showed magnetic resonance imaging (MRI) focal restricted diffusion confined to the left temporal and occipital cortices. Thirteen months later, diffusion-weighted images revealed a bilateral cortical ribbon sign involving all lobes. After 1 month, the patient developed gait instability and cognitive decline rapidly evolving to severe dementia and death within 3 months. Prion protein gene sequence, molecular, and neuropathological studies confirmed the diagnosis of sporadic Creutzfeldt–Jakob disease (sCJD) MM1 subtype. Here we show the kinetics of MRI changes and prion spreading in preclinical sCJD MM1. Ann Neurol 2016;80:629–632.
AB - An asymptomatic 74-year-old woman, on follow-up for a carotid body tumor, showed magnetic resonance imaging (MRI) focal restricted diffusion confined to the left temporal and occipital cortices. Thirteen months later, diffusion-weighted images revealed a bilateral cortical ribbon sign involving all lobes. After 1 month, the patient developed gait instability and cognitive decline rapidly evolving to severe dementia and death within 3 months. Prion protein gene sequence, molecular, and neuropathological studies confirmed the diagnosis of sporadic Creutzfeldt–Jakob disease (sCJD) MM1 subtype. Here we show the kinetics of MRI changes and prion spreading in preclinical sCJD MM1. Ann Neurol 2016;80:629–632.
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UR - http://www.scopus.com/inward/citedby.url?scp=84988892471&partnerID=8YFLogxK
U2 - 10.1002/ana.24757
DO - 10.1002/ana.24757
M3 - Article
AN - SCOPUS:84988892471
VL - 80
SP - 629
EP - 632
JO - Annals of Neurology
JF - Annals of Neurology
SN - 0364-5134
IS - 4
ER -