TY - JOUR
T1 - Long-term predictors of impaired fasting glucose and type 2 diabetes in subjects with family history of type 2 diabetes
T2 - A 12-years follow-up of the Brisighella Heart Study historical cohort
AU - Cicero, A. F G
AU - Derosa, G.
AU - Rosticci, M.
AU - D'Addato, S.
AU - Agnoletti, D.
AU - Borghi, C.
AU - Borghi, Claudio
AU - Missiroli, Davide
AU - Laghi, Franco
AU - Viozzi, Paolo
AU - Bagnaresi, Lidia
AU - Belletti, Ercole
AU - Samorè, Claudio
AU - Naldi, Antonio
AU - Ruberto, Eleonora
AU - Cagnati, Marcella
AU - Rosticci, Martina
AU - Rizzoli, Elisabetta
AU - Giovannini, Marina
AU - Grandi, Elisa
AU - Ancarani, Elena
AU - Baronio, Cristina
AU - Brancaleoni, Barbara
AU - Faenza, Simone
AU - Grossi, Giulia
AU - Parini, Angelo
PY - 2014
Y1 - 2014
N2 - Aim: To identify and quantify the role of different risk factors in the long-term development of IFG and T2DM in a rural Italian population sample with family history of T2DM. Methods: We selected a sample of 1271 adult subjects from among those 1851 consecutively visited during four consecutive Brisighella Heart Study surveys (1996-2008), then selecting those ones with a family history of T2DM. Thus, we obtained a final sample including 545 subjects and for which a full clinical and ematochemistry data set was available. Results: The Cox-regression model better predicting the incident IFG and T2DM included age, gender, FPG, TG and SUA. The model best predicting the incident IFG status alone (without T2DM) is very similar to that predicting both IFG and T2DM, including the same predictors. Finally, the model best predicting T2DM (excluding IFG) simply includes FPG, BMI and ALT/AST ratio. Repeating the Cox-regression analysis using BMI as a covariate, TG appears to be also a significant predictor of T2DM (HR 1.018 95% CI 1.009-1.041, p= 0.013). Conclusion: In a sample of subjects with a family history of diabetes the best long-term predictors of IFG are age, gender, FPG, TG and SUA, while those of T2DM are FPG and BMI.
AB - Aim: To identify and quantify the role of different risk factors in the long-term development of IFG and T2DM in a rural Italian population sample with family history of T2DM. Methods: We selected a sample of 1271 adult subjects from among those 1851 consecutively visited during four consecutive Brisighella Heart Study surveys (1996-2008), then selecting those ones with a family history of T2DM. Thus, we obtained a final sample including 545 subjects and for which a full clinical and ematochemistry data set was available. Results: The Cox-regression model better predicting the incident IFG and T2DM included age, gender, FPG, TG and SUA. The model best predicting the incident IFG status alone (without T2DM) is very similar to that predicting both IFG and T2DM, including the same predictors. Finally, the model best predicting T2DM (excluding IFG) simply includes FPG, BMI and ALT/AST ratio. Repeating the Cox-regression analysis using BMI as a covariate, TG appears to be also a significant predictor of T2DM (HR 1.018 95% CI 1.009-1.041, p= 0.013). Conclusion: In a sample of subjects with a family history of diabetes the best long-term predictors of IFG are age, gender, FPG, TG and SUA, while those of T2DM are FPG and BMI.
KW - Epidemiology
KW - Family history
KW - Italy
KW - Prediction
KW - Risk factors
KW - Type 2 diabetes
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U2 - 10.1016/j.diabres.2014.02.005
DO - 10.1016/j.diabres.2014.02.005
M3 - Article
C2 - 24582152
AN - SCOPUS:84898540277
VL - 104
SP - 183
EP - 188
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
SN - 0168-8227
IS - 1
ER -