Long-term prognostic value of blood pressure variability in the general population: Results of the Pressioni Arteriose Monitorate e Lassociazioni Study

Giuseppe Mancia, Michele Bombelli, Rita Facchetti, Fabiana Madotto, Giovanni Corrao, Fosca Quarti Trevano, Guido Grassi, Roberto Sega

Research output: Contribution to journalArticlepeer-review

Abstract

The hypothesis has been advanced that cardiovascular prognosis is related not only to 24-hour mean blood pressure but also to blood pressure variability. Data, however, are inconsistent, and no long-term prognostic study is available. In 2012 individuals randomly selected from the population of Monza (Milan), 24-hour ambulatory blood pressure (Spacelabs 90207) was measured via readings spaced by 20 minutes. Systolic and diastolic blood pressure variability was obtained by calculating the following: (1) the SD of 24-hour, day, and night mean values; (2) the day-night blood pressure difference; and (3) the residual or erratic blood pressure variability (Fourier spectral analysis). Fatal cardiovascular and noncardiovascular events were registered for 148 months. When adjusted for age, sex, 24-hour mean blood pressure, and other risk factors, there was no relationship between the risk of death and 24-hour, day, and night blood pressure SDs. In contrast, the adjusted risk of cardiovascular death was inversely related to day-night diastolic BP difference (β coefficient=-0.040; P

Original languageEnglish
Pages (from-to)1265-1270
Number of pages6
JournalHypertension
Volume49
Issue number6
DOIs
Publication statusPublished - Jun 2007

Keywords

  • Blood pressure monitoring
  • Blood pressure variability
  • Morbidity
  • Mortality
  • Population science
  • Risk factors

ASJC Scopus subject areas

  • Internal Medicine

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