Abstract
BACKGROUND: Cardiac magnetic resonance (CMR) is useful for the diagnosis of left ventricular noncompaction (LVNC). However, there are limited data regarding its prognostic value.
OBJECTIVES: The goal of this study was to evaluate the prognostic relevance of CMR findings in patients with LVNC.
METHODS: A total of 113 patients with an echocardiographic diagnosis of LVNC underwent CMR at 5 referral centers. CMR diagnostic criterion of LVNC (noncompacted/compacted ratio >2.3 in end-diastole) was confirmed in all patients. We performed left ventricular (LV) and right ventricular quantitative analysis and late gadolinium enhancement (LGE) assessments and analyzed the following LVNC diagnostic criteria: left ventricular noncompacted myocardial mass (LV-ncMM) >20% and >25%, total LV-ncMM index >15 g/m(2), noncompacted/compacted ratio ≥3:1 ≥1 of segments 1 to 3 and 7 to 16 or ≥2:1 in at least 1 of segments 4 to 6 of the American Heart Association model. Outcome was a composite of thromboembolic events, heart failure hospitalizations, ventricular arrhythmias, and cardiac death.
RESULTS: At a mean follow-up of 48 ± 24 months, cardiac events (CEs) occurred in 36 patients (16 heart failure hospitalizations, 10 ventricular arrhythmias, 5 cardiac deaths, and 5 thromboembolic events). LV dilation, impaired LV ejection fraction, and LV-ncMM >20% was significantly more frequent in patients with CEs. LV fibrosis was detected by using LGE in 11 cases. CMR predictors of CEs were LV dilation and LGE. LGE was associated with improved prediction of CEs, compared with clinical data and CMR functional parameters in all 3 models. No CEs occurred in patients without dilated cardiomyopathy and/or LGE.
CONCLUSIONS: In patients with LVNC evaluated by using CMR, the degree of LV trabeculation seems to have no prognostic impact over and above LV dilation, LV systolic dysfunction, and presence of LGE.
| Original language | English |
|---|---|
| Pages (from-to) | 2166-2181 |
| Number of pages | 16 |
| Journal | Journal of the American College of Cardiology |
| Volume | 68 |
| Issue number | 20 |
| DOIs | |
| Publication status | Published - Nov 15 2016 |
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- Journal Article
Cite this
Long-Term Prognostic Value of Cardiac Magnetic Resonance in Left Ventricle Noncompaction : A Prospective Multicenter Study. / Andreini, Daniele; Pontone, Gianluca; Bogaert, Jan; Roghi, Alberto; Barison, Andrea; Schwitter, Juerg; Mushtaq, Saima; Vovas, Georgios; Sormani, Paola; Aquaro, Giovanni D.; Monney, Pierre; Segurini, Chiara; Guglielmo, Marco; Conte, Edoardo; Fusini, Laura; Dello Russo, Antonio; Lombardi, Massimo; Gripari, Paola; Baggiano, Andrea; Fiorentini, Cesare; Lombardi, Federico; Bartorelli, Antonio L; Pepi, Mauro; Masci, Pier Giorgio.
In: Journal of the American College of Cardiology, Vol. 68, No. 20, 15.11.2016, p. 2166-2181.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Long-Term Prognostic Value of Cardiac Magnetic Resonance in Left Ventricle Noncompaction
T2 - A Prospective Multicenter Study
AU - Andreini, Daniele
AU - Pontone, Gianluca
AU - Bogaert, Jan
AU - Roghi, Alberto
AU - Barison, Andrea
AU - Schwitter, Juerg
AU - Mushtaq, Saima
AU - Vovas, Georgios
AU - Sormani, Paola
AU - Aquaro, Giovanni D.
AU - Monney, Pierre
AU - Segurini, Chiara
AU - Guglielmo, Marco
AU - Conte, Edoardo
AU - Fusini, Laura
AU - Dello Russo, Antonio
AU - Lombardi, Massimo
AU - Gripari, Paola
AU - Baggiano, Andrea
AU - Fiorentini, Cesare
AU - Lombardi, Federico
AU - Bartorelli, Antonio L
AU - Pepi, Mauro
AU - Masci, Pier Giorgio
N1 - Copyright © 2016 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
PY - 2016/11/15
Y1 - 2016/11/15
N2 - BACKGROUND: Cardiac magnetic resonance (CMR) is useful for the diagnosis of left ventricular noncompaction (LVNC). However, there are limited data regarding its prognostic value.OBJECTIVES: The goal of this study was to evaluate the prognostic relevance of CMR findings in patients with LVNC.METHODS: A total of 113 patients with an echocardiographic diagnosis of LVNC underwent CMR at 5 referral centers. CMR diagnostic criterion of LVNC (noncompacted/compacted ratio >2.3 in end-diastole) was confirmed in all patients. We performed left ventricular (LV) and right ventricular quantitative analysis and late gadolinium enhancement (LGE) assessments and analyzed the following LVNC diagnostic criteria: left ventricular noncompacted myocardial mass (LV-ncMM) >20% and >25%, total LV-ncMM index >15 g/m(2), noncompacted/compacted ratio ≥3:1 ≥1 of segments 1 to 3 and 7 to 16 or ≥2:1 in at least 1 of segments 4 to 6 of the American Heart Association model. Outcome was a composite of thromboembolic events, heart failure hospitalizations, ventricular arrhythmias, and cardiac death.RESULTS: At a mean follow-up of 48 ± 24 months, cardiac events (CEs) occurred in 36 patients (16 heart failure hospitalizations, 10 ventricular arrhythmias, 5 cardiac deaths, and 5 thromboembolic events). LV dilation, impaired LV ejection fraction, and LV-ncMM >20% was significantly more frequent in patients with CEs. LV fibrosis was detected by using LGE in 11 cases. CMR predictors of CEs were LV dilation and LGE. LGE was associated with improved prediction of CEs, compared with clinical data and CMR functional parameters in all 3 models. No CEs occurred in patients without dilated cardiomyopathy and/or LGE.CONCLUSIONS: In patients with LVNC evaluated by using CMR, the degree of LV trabeculation seems to have no prognostic impact over and above LV dilation, LV systolic dysfunction, and presence of LGE.
AB - BACKGROUND: Cardiac magnetic resonance (CMR) is useful for the diagnosis of left ventricular noncompaction (LVNC). However, there are limited data regarding its prognostic value.OBJECTIVES: The goal of this study was to evaluate the prognostic relevance of CMR findings in patients with LVNC.METHODS: A total of 113 patients with an echocardiographic diagnosis of LVNC underwent CMR at 5 referral centers. CMR diagnostic criterion of LVNC (noncompacted/compacted ratio >2.3 in end-diastole) was confirmed in all patients. We performed left ventricular (LV) and right ventricular quantitative analysis and late gadolinium enhancement (LGE) assessments and analyzed the following LVNC diagnostic criteria: left ventricular noncompacted myocardial mass (LV-ncMM) >20% and >25%, total LV-ncMM index >15 g/m(2), noncompacted/compacted ratio ≥3:1 ≥1 of segments 1 to 3 and 7 to 16 or ≥2:1 in at least 1 of segments 4 to 6 of the American Heart Association model. Outcome was a composite of thromboembolic events, heart failure hospitalizations, ventricular arrhythmias, and cardiac death.RESULTS: At a mean follow-up of 48 ± 24 months, cardiac events (CEs) occurred in 36 patients (16 heart failure hospitalizations, 10 ventricular arrhythmias, 5 cardiac deaths, and 5 thromboembolic events). LV dilation, impaired LV ejection fraction, and LV-ncMM >20% was significantly more frequent in patients with CEs. LV fibrosis was detected by using LGE in 11 cases. CMR predictors of CEs were LV dilation and LGE. LGE was associated with improved prediction of CEs, compared with clinical data and CMR functional parameters in all 3 models. No CEs occurred in patients without dilated cardiomyopathy and/or LGE.CONCLUSIONS: In patients with LVNC evaluated by using CMR, the degree of LV trabeculation seems to have no prognostic impact over and above LV dilation, LV systolic dysfunction, and presence of LGE.
KW - Journal Article
U2 - 10.1016/j.jacc.2016.08.053
DO - 10.1016/j.jacc.2016.08.053
M3 - Article
C2 - 27855806
VL - 68
SP - 2166
EP - 2181
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
SN - 0735-1097
IS - 20
ER -