TY - JOUR
T1 - Long-term prognostic value of dobutamine stress echocardiography compared with myocardial perfusion scanning in patients unable to perform exercise tests
AU - Schinkel, Arend F L
AU - Bax, Jeroen J.
AU - Elhendy, Abdou
AU - Van Domburg, Ron T.
AU - Valkema, Roelf
AU - Vourvouri, Eleni
AU - Bountioukos, Manolis
AU - Rizzello, Vittoria
AU - Biagini, Elena
AU - Agricola, Eustachio
AU - Krenning, Eric P.
AU - Simoons, Maarten L.
AU - Poldermans, Don
PY - 2004/7/1
Y1 - 2004/7/1
N2 - Purpose To compare the long-term prognostic value of dobutamine stress echocardiography and dobutamine stress single photon emission computed tomography (SPECT) in patients unable to perform an exercise test. Methods We assessed the prognostic value of dobutamine stress technetium 99m ( 99mTc)-sestamibi SPECT and dobutamine stress echocardiography in 301 patients who were unable to perform exercise tests. Outcomes during a mean (± SD) follow-up of 7.3 ± 2.8 years were overall death, cardiac death, nonfatal myocardial infarction, and late (>60 days) coronary revascularization. Results Abnormal myocardial perfusion was detected in 66% of patients (n = 198), while 60% (n = 182) had an abnormal stress echocardiogram; agreement was 82% (κ = 0.62). During the follow-up period, 100 deaths (33%) occurred, of which 43% were due to cardiac causes. Nonfatal myocardial infarction occurred in 23 patients (8%), and 29 (10%) underwent late revascularization. With stress SPECT, annual event rates were 0.7% for cardiac death and 3.6% for all cardiac events after a normal scan, and 2.6% for cardiac death and 6.5% for all cardiac events after an abnormal scan (P 99mTc-sestamibi SPECT and dobutamine stress echocardiography provide comparable long-term prognostic information in addition to that afforded by clinical data.
AB - Purpose To compare the long-term prognostic value of dobutamine stress echocardiography and dobutamine stress single photon emission computed tomography (SPECT) in patients unable to perform an exercise test. Methods We assessed the prognostic value of dobutamine stress technetium 99m ( 99mTc)-sestamibi SPECT and dobutamine stress echocardiography in 301 patients who were unable to perform exercise tests. Outcomes during a mean (± SD) follow-up of 7.3 ± 2.8 years were overall death, cardiac death, nonfatal myocardial infarction, and late (>60 days) coronary revascularization. Results Abnormal myocardial perfusion was detected in 66% of patients (n = 198), while 60% (n = 182) had an abnormal stress echocardiogram; agreement was 82% (κ = 0.62). During the follow-up period, 100 deaths (33%) occurred, of which 43% were due to cardiac causes. Nonfatal myocardial infarction occurred in 23 patients (8%), and 29 (10%) underwent late revascularization. With stress SPECT, annual event rates were 0.7% for cardiac death and 3.6% for all cardiac events after a normal scan, and 2.6% for cardiac death and 6.5% for all cardiac events after an abnormal scan (P 99mTc-sestamibi SPECT and dobutamine stress echocardiography provide comparable long-term prognostic information in addition to that afforded by clinical data.
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U2 - 10.1016/j.amjmed.2004.01.021
DO - 10.1016/j.amjmed.2004.01.021
M3 - Article
C2 - 15210381
AN - SCOPUS:2942729741
VL - 117
SP - 1
EP - 9
JO - American Journal of Medicine
JF - American Journal of Medicine
SN - 0002-9343
IS - 1
ER -