Long-term prognostic value of stress myocardial perfusion imaging and coronary computed tomography angiography: A meta-analysis

Valeria Cantoni, Roberta Green, Wanda Acampa, Mario Petretta, Domenico Bonaduce, Marco Salvatore, Alberto Cuocolo

Research output: Contribution to journalArticlepeer-review

Abstract

Background: We conducted a meta-analysis to compare the long-term prognostic value of stress single-photon emission computed tomography myocardial perfusion imaging (MPI) and coronary computed tomography angiography (CCTA) for adverse cardiovascular events in subjects with suspected or known coronary artery disease. Methods and Results: We searched PubMed, Cochrane, Web of Science, and Scopus database between January 2000 and December 2014 for stress MPI and CCTA studies that followed up ≥ 100 subjects for ≥ 2.5 years and provided the unadjusted and/or adjusted hazard ratio (HR) at Cox regression analysis. Summary risk estimates for abnormal perfusion at MPI or ≥ 50% coronary stenosis at CCTA were derived in random effect regression analysis, and causes of heterogeneity were determined in meta-regression analysis. We identified 21 eligible articles (10 MPI and 11 CCTA) including 25,258 participants (13,484 in MPI and 11,774 in CCTA studies) with suspected or known coronary artery disease. Among the included publications, 8 MPI and 8 CCTA studies reported the HR for the occurrence of hard events (death and nonfatal myocardial infarction). The pooled HR was comparable for MPI and CCTA studies. The HR for the occurrence of a combined endpoint including revascularization as event was reported in 4 MPI and 6 CCTA studies. The pooled HR was higher for CCTA compared to MPI (P 

Original languageEnglish
Pages (from-to)185-197
Number of pages13
JournalJournal of Nuclear Cardiology
Volume23
Issue number2
DOIs
Publication statusPublished - Apr 1 2016

Keywords

  • computed tomography (CT)
  • coronary artery disease
  • meta-analysis
  • Myocardial perfusion imaging: SPECT
  • prognosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

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