Long-term prognostic value of white coat hypertension: An insight from diagnostic use of both ambulatory and home blood pressure measurements

Giuseppe Mancia, Michele Bombelli, Gianmaria Brambilla, Rita Facchetti, Roberto Sega, Elena Toso, Guido Grassi

Research output: Contribution to journalArticle

Abstract

The prognostic value of white coat hypertension (WCH) is still debated. In 2051 subjects representative of the general population of Monza, we measured office, ambulatory, and home blood pressure (BP). The risk of cardiovascular and all-cause mortality was assessed over 16 years in normotensive, sustained hypertensive, and WCH subjects, the last group being defined as usually done in clinical practice (ie, by normality of 1 out-of-office [ambulatory or home] BP with an office BP elevation). Compared with normotensive subjects, the risk of cardiovascular mortality, as adjusted for potential confounders, showed a progressive significant increase in WCH and sustained hypertensive subjects (2.04 and 2.94; P=0.006). In either group, a significant increase in adjusted risk was also seen for all-cause mortality. However, when the WCH group was subdivided into 2 subgroups, that is, subjects in whom both out-of-office BPs were normal (true WCH, 42%) or one BP was normal whereas the other was elevated (partial WCH, 58%), only the latter showed a significantly greater adjusted risk of cardiovascular and all-cause mortality (2.76 and 1.58; P

Original languageEnglish
Pages (from-to)168-174
Number of pages7
JournalHypertension
Volume62
Issue number1
DOIs
Publication statusPublished - Jul 2013

Keywords

  • ambulatory blood pressure monitoring
  • home blood pressure monitoring
  • mortality
  • prognosis
  • white coat hypertension

ASJC Scopus subject areas

  • Internal Medicine

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