Long-term resistance to HIV infection in vertical HIV infection: Cytokine production, HIV isolation, and HIV phenotype define long-term resistant hosts

Alessandra Vigano, Claudia Balotta, Daria Trabattoni, Dorella Bricalli, Lina Crupi, Elvia Palomba, Luisa Galli, Antonino Salvaggio, Maria Luisa Fusi, Stefania Ruzzante, Emilia Massironi, Maria Chiara Colombo, Nicola Principi, Massimo Galli, Mario Clerici

Research output: Contribution to journalArticle

Abstract

We analyzed immunologic (CD4 and CD8 slopes; interferon-γ, interleukin-2, interleukin-10, and chemokines production; concentration of IgE; β2-microglobulin) and virologic (p24; HIV isolability and phenotype; plasma viremia) parameters in HIV vertically infected children ≤ 8 years of age without disease progression or mild symptoms and an absolute CD4+ count ≤ 500/μl with CD4+ percentage ≤ 25%. The results were compared to those of two control groups: (1) slow progressors, children ≤ 8 years of age with moderate symptomatology and/or moderate CD4 depletion, and (2) progressors, children ≤ 8 years of age with severe clinical disease and/or severe CD4 depletion. Pediatric long-term resistant hosts were characterized by higher production of interleukin-2 and interferon-γ and lower production of interleukin-10, normal concentration of IgE, HIV isolates with a non-syncytium-inducing phenotype, and lower plasma viremia. This condition was not associated with the concentration of β2-microglobulin, p24, and chemokines, or with HIV isolability. The IL-10/IL-2 ratio best correlated with both CD4 counts and disease progression. Thus, vertically infected children showing resistance to disease progression are immunologically and virologically distinct from those in whom progressive HIV infection is observed.

Original languageEnglish
Pages (from-to)169-176
Number of pages8
JournalPathobiology
Volume65
Issue number4
Publication statusPublished - 1997

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Keywords

  • Cytokine
  • Disease progression
  • HIV
  • Immunology
  • Virology

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Biochemistry
  • Immunology and Allergy
  • Cell Biology

Cite this

Vigano, A., Balotta, C., Trabattoni, D., Bricalli, D., Crupi, L., Palomba, E., Galli, L., Salvaggio, A., Fusi, M. L., Ruzzante, S., Massironi, E., Colombo, M. C., Principi, N., Galli, M., & Clerici, M. (1997). Long-term resistance to HIV infection in vertical HIV infection: Cytokine production, HIV isolation, and HIV phenotype define long-term resistant hosts. Pathobiology, 65(4), 169-176.