Long-term respiratory functional results after pneumonectomy

Luca Luzzi, Sara Tenconi, Luca Voltolini, Piero Paladini, Claudia Ghiribelli, Maurizio Di Bisceglie, Giuseppe Gotti

Research output: Contribution to journalArticle

Abstract

Introduction: The aim of this study is to evaluate the long-term respiratory outcome of patients who underwent pneumonectomy for non-small cell lung cancer (NSCLC), analysing functional tests. Materials and methods: Twenty-seven consecutive patients who were candidates for pneumonectomy performed spirometry before and at least 24 months after surgery in the same laboratory. Diffusion of carbon monoxide and the most common dynamic and static lung volumes were evaluated in percentage of predicted and compared. Results: A significant inverse correlation was observed between the preoperative FEV1 (%) and FVC (%) and their postoperative loss, respectively r = -641 (p <0.0001) and r = -789 (p <0.0001). Also the correlation between the RV/TLC ratio and the FEV1 loss confirmed a better postoperative outcome in patients with major airway obstruction (p = 0.02). To investigate these data, the series were divided into two groups: group A included BPCO patients with a FEV1 lower than 80%, the others were considered group B. Group B showed a significant major postoperative FEV1 (%) and FVC (%) impairment, 31% versus 12%, p = 0.005, and FVC (%) loss, 37% versus 16% (p = 0.02), meanwhile group A showed a significant major postoperative RV (%) reduction, 43% versus 17%, p = 0.03. Despite being significantly higher preoperatively in BPCO patients, the RV% becomes similar between the two groups in the postoperative. Conclusions: In our experience patients with major preoperative airway obstruction who underwent pneumonectomy had lower impairment in FEV1% at almost one year after surgery than those with normal respiratory function. The resection of a certain amount of non-functional parenchyma associated with the mediastinal shift, with an improvement of the chest cavity for the remaining lung, could give a reduction volume effect in BPCO/emphysematous patients.

Original languageEnglish
Pages (from-to)164-168
Number of pages5
JournalEuropean Journal of Cardio-thoracic Surgery
Volume34
Issue number1
DOIs
Publication statusPublished - Jul 2008

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Pneumonectomy
Airway Obstruction
Lung
Spirometry
Carbon Monoxide
Non-Small Cell Lung Carcinoma
Thorax

Keywords

  • BPCO
  • Lung cancer
  • Lung diffusion capacity
  • Lung resection
  • Pneumonectomy
  • Pulmonary function test

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Luzzi, L., Tenconi, S., Voltolini, L., Paladini, P., Ghiribelli, C., Di Bisceglie, M., & Gotti, G. (2008). Long-term respiratory functional results after pneumonectomy. European Journal of Cardio-thoracic Surgery, 34(1), 164-168. https://doi.org/10.1016/j.ejcts.2008.03.064

Long-term respiratory functional results after pneumonectomy. / Luzzi, Luca; Tenconi, Sara; Voltolini, Luca; Paladini, Piero; Ghiribelli, Claudia; Di Bisceglie, Maurizio; Gotti, Giuseppe.

In: European Journal of Cardio-thoracic Surgery, Vol. 34, No. 1, 07.2008, p. 164-168.

Research output: Contribution to journalArticle

Luzzi, L, Tenconi, S, Voltolini, L, Paladini, P, Ghiribelli, C, Di Bisceglie, M & Gotti, G 2008, 'Long-term respiratory functional results after pneumonectomy', European Journal of Cardio-thoracic Surgery, vol. 34, no. 1, pp. 164-168. https://doi.org/10.1016/j.ejcts.2008.03.064
Luzzi L, Tenconi S, Voltolini L, Paladini P, Ghiribelli C, Di Bisceglie M et al. Long-term respiratory functional results after pneumonectomy. European Journal of Cardio-thoracic Surgery. 2008 Jul;34(1):164-168. https://doi.org/10.1016/j.ejcts.2008.03.064
Luzzi, Luca ; Tenconi, Sara ; Voltolini, Luca ; Paladini, Piero ; Ghiribelli, Claudia ; Di Bisceglie, Maurizio ; Gotti, Giuseppe. / Long-term respiratory functional results after pneumonectomy. In: European Journal of Cardio-thoracic Surgery. 2008 ; Vol. 34, No. 1. pp. 164-168.
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