Long-term results in children with head and neck rhabdomyosarcoma

Maria Carmen Affinita, Andrea Ferrari, Giuseppe Maria Milano, Giovanni Scarzello, Francesco De Leonardis, Luca Coccoli, Roberta Pericoli, Eleonora Basso, Ilaria Zanetti, Angela Scagnellato, Gianni Bisogno

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BACKGROUND: Rhabdomyosarcoma (RMS) occurring at nonparameningeal head and neck (NPM-HN) sites carries a better prognosis than parameningeal RMS and some other sites. We analyzed the treatments administered and results obtained in patients with localized NPM-HN RMS, included in the protocols coordinated by the Italian Soft Tissue Sarcoma Committee (STSC), in an effort to identify prognostic factors that could facilitate the tailoring of treatment.METHODS: Sixty-six patients up to 18 years of age with previously untreated, localized NPM-HN RMS were prospectively registered in three consecutive protocols: RMS79, RMS88, and RMS96. Primary surgery was recommended when complete tumor resection was deemed feasible without mutilations. In other cases, only a biopsy was performed, followed by chemotherapy and delayed surgery and/or radiotherapy (RT).RESULTS: NPM-HN RMS showed favorable characteristics: 72.7% were
Original languageEnglish
JournalPediatric Blood and Cancer
Issue number3
Publication statusE-pub ahead of print - Nov 8 2017


  • Journal Article


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