Long-term results of combined chemotherapy-radiotherapy approach in Hodgkin's disease: Superiority of ABVD plus radiotherapy versus MOPP plus radiotherapy

A. Santoro, G. Bonadonna, P. Valagussa, R. Zucali, S. Viviani, F. Villani, A. M. Pagnoni, V. Bonfante, R. Musumeci, F. Crippa

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Abstract

In an attempt to reduce some of the delayed sequelae associated with combined modality therapy in Hodgkin's disease, we randomly tested stages iiB, iiiA, and iiiB MOPP (mechlorethamine, vincristine, procarbazine, and prednisone) v ABVD (adriamycin, bleomycin, vinblastine, and dacarbazine). In 232 previously untreated patients, three cycles of either combination preceded and followed extensive irradiation. The complete remission rate was 80.7% following MOPP and 92.4% following ABVD (P

Original languageEnglish
Pages (from-to)27-37
Number of pages11
JournalJournal of Clinical Oncology
Volume5
Issue number1
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Santoro, A., Bonadonna, G., Valagussa, P., Zucali, R., Viviani, S., Villani, F., Pagnoni, A. M., Bonfante, V., Musumeci, R., & Crippa, F. (1987). Long-term results of combined chemotherapy-radiotherapy approach in Hodgkin's disease: Superiority of ABVD plus radiotherapy versus MOPP plus radiotherapy. Journal of Clinical Oncology, 5(1), 27-37.