Long-term results of fertility-sparing treatment for early-stage cervical cancer

Giorgio Bogani, Valentina Chiappa, Daniele Vinti, Edgardo Somigliana, Francesca Filippi, Giulia Murru, Ferdinando Murgia, Fabio Martinelli, Antonino Ditto, Francesco Raspagliesi

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Abstract

Objective: To evaluate the long-term outcomes of young early stage cervical cancer patients wishing to preserve their childbearing potential. Methods: Data of young (aged <40 years) patients with early stage cervical cancer were prospectively collected. All patients with stage IA2, IB1 and IB2 cervical cancer were included; they have cervical conization and pelvic node dissection performed via minimally invasive surgery. Survival outcomes were assessed with the Kaplan-Meier model. Results: Overall, 32 patients met the inclusion criteria. Mean (SD) age of the population included was 33 (±4). According to the FIGO 2018 staging system, the stage of disease was IA2, IB1 and IB2 in 9 (28%), 21 (66%) and 2 (6%) cases, respectively. All patients included had cervical conization and laparoscopic pelvic node assessment, including systematic pelvic lymphadenectomy (N = 30, 94%) and sentinel node mapping (N = 2, 6%). In six (19%) patients the planned conservative treatment was discontinued. Median follow-up was 75 (range, 12–184) months. No recurrent disease was diagnosed among patients undergoing conservative treatment; while 2 out of 6 patients having definitive surgical or radiotherapy treatments developed recurrent disease. Five-year disease free and overall survivals were 94% and 97%, respectively. Considering reproductive outcomes, 11 (69%) out of 16 patients who attempted to conceive got pregnant. Conclusions: Cervical conization and pelvic nodes assessment could be considered a valid treatment modality for early-stage cervical cancer patients who are wishing to preserve their childbearing potential.

Original languageEnglish
Pages (from-to)89-94
Number of pages6
JournalGynecologic Oncology
Volume154
Issue number1
DOIs
Publication statusPublished - Jul 2019

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Uterine Cervical Neoplasms
Fertility
Conization
Therapeutics
Minimally Invasive Surgical Procedures
Lymph Node Excision
Disease-Free Survival
Dissection
Radiotherapy
Survival

Keywords

  • Cervical cancer
  • Conization
  • Conservative surgery
  • Fertility-sparing
  • Lymph node

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynaecology

Cite this

Long-term results of fertility-sparing treatment for early-stage cervical cancer. / Bogani, Giorgio; Chiappa, Valentina; Vinti, Daniele; Somigliana, Edgardo; Filippi, Francesca; Murru, Giulia; Murgia, Ferdinando; Martinelli, Fabio; Ditto, Antonino; Raspagliesi, Francesco.

In: Gynecologic Oncology, Vol. 154, No. 1, 07.2019, p. 89-94.

Research output: Contribution to journalArticle

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