Long-term results of intrapericardial chemotherapeutic treatment of malignant pericardial effusions with thiotepa

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Objective: Pericardial involvement is a common feature in different neoplastic diseases, having a strong influence on the natural history of the disease and on the quality of life of the patients. This study was performed in order to investigate the long-term effects of intracavitary treatment with thiotepa in the reduction of pericardial effusion (PE) recurrences. Design: Prospective controlled intervention study. Setting: European Institute of Oncology, Milan, Italy. Patients: We studied 33 patients, 15 men and 18 women, with malignant PE, who were affected by breast cancer (11 patients), lung cancer (16 patients), microcytoma (4 patients), endometrial cancer (1 patients), and melanoma (1 patient). Intervention: All patients with large PE, with or without cardiac tamponade, underwent percutaneous pericardiocentesis (PC) under echocardiographic monitoring. Patients with neoplastic cells in drained fluid were considered to be eligible for treatment. After drainage, the catheter was maintained in the pericardial sac for the instillation of a sclerosing, alkylating antiblastic agent (thiotepa) on days 1, 3, and 5 after the PC (15 mg at each step). Results: No procedure-related complications or side effects were observed. Two patients died because of disease progression, without PE evidence. No PE occurred in the remaining patients during the first month. Three recurrences occurred (9.1%), requiring additional PC and intrapericardial treatment. The median survival lime was 115 days (range, 22 to 1,108 days) in the overall population, and 272 days in patients with breast cancer. Conclusions: Intrapericardial treatment with thiotepa carries a minimal risk and is a repeatable procedure that can dramatically increase quality of life, or even can improve survival and the natural history of disease in cancer patients.

Original languageEnglish
Pages (from-to)1412-1416
Number of pages5
Issue number5
Publication statusPublished - Nov 2004


  • Antineoplastic agents
  • Cardiac tamponade
  • Neoplasms
  • Pericardial effusion
  • Thiotepa

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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