Long-term results of mitral repair in patients with severe left ventricular dysfunction and secondary mitral regurgitation: does the technique matter?

M. De Bonis, Elizabeth Lapenna, Fabio Barili, Teodora Nisi, M. Calabrese, F. Pappalardo, G. La Canna, G. A. Pozzoli, Nicola Buzzatti, A. Giacomini, Emanuela Alati, O. Alfieri

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: An isolated undersized annuloplasty was used to treat mitral regurgitation (MR) secondary to dilated cardiomyopathy (DCM) if the baseline coaptation depth (CD) was /=1 cm), the edge-to-edge (EE) technique was combined with annuloplasty to improve the durability of the repair. The long-term results of this approach are unknown and represent the objective of this study. METHODS: To obtain long-term outcome data, we included in the study population the first 105 consecutive patients with severe left ventricular dysfunction (ejection fraction 29 +/- 6.6%) and secondary MR submitted to mitral valve repair. Forty patients underwent isolated undersized annuloplasty and 65 patients received the EE technique combined with annuloplasty. Preoperative and postoperative data were prospectively entered into a dedicated database. Clinical and echocardiographic follow-ups were performed in our institutional outpatient clinic. RESULTS: Follow-up was 90% complete. The median follow-up time was 7.2 years (interquartile range 4.3;10.4). The longest follow-up time was 16.5 years. A comparative analysis between the annuloplasty group and the EE group was performed. Baseline LV dimensions and function were slightly worse in the EE group, but only the severity of tethering was significantly more pronounced than in the annuloplasty group. Hospital mortality (3 vs 2.5%, P = 1.0) and 10-year overall survival (42 +/- 6.7 vs 55 +/- 8.5%, P = 0.2) were not significantly different in the EE and annuloplasty group, respectively. Cumulative incidence functions of cardiac death were similar as well (at 10-years, 34.3 +/- 8.1 vs 37.9 +/- 6.4%, respectively, P = 0.4). At 10 years, cumulative incidence function of recurrence of MR >/=3+ was lower in the EE patients (10.3 +/- 4.1 vs 30.8+/-8.0%, P = 0.01). Isolated annuloplasty [hazard ratio (HR) 4.84, 95% confidence interval (CI) 1.46-16.1, P = 0.01] and residual MR >1+ at hospital discharge (HR 5.25, 95% CI 2.00-13.8, P /=3. Failure of repair was associated with recurrence of New York Heart Association III or IV symptoms (P <0.001). CONCLUSIONS: In patients with end-stage DCM and secondary MR, the association of the EE technique to the undersized annuloplasty significantly decreases the rate of recurrent MR at long-term. This higher repair durability did not translate into a better long-term prognosis in this series.
Original languageEnglish
Pages (from-to)882-889
Number of pages8
JournalEuropean Journal of Cardio-thoracic Surgery
Volume50
Issue number5
Publication statusPublished - 2016

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Mitral Valve Insufficiency
Left Ventricular Dysfunction
Dilated Cardiomyopathy
Confidence Intervals
Recurrence
Incidence
Hospital Mortality
Ambulatory Care Facilities
Mitral Valve
Stroke Volume
Databases
Survival
Population

Keywords

  • Edge-to-edge repair
  • Mitral valve repair
  • Secondary mitral regurgitation
  • Undersized annuloplasty

Cite this

Long-term results of mitral repair in patients with severe left ventricular dysfunction and secondary mitral regurgitation: does the technique matter? / De Bonis, M.; Lapenna, Elizabeth; Barili, Fabio; Nisi, Teodora; Calabrese, M.; Pappalardo, F.; La Canna, G.; Pozzoli, G. A.; Buzzatti, Nicola; Giacomini, A.; Alati, Emanuela; Alfieri, O.

In: European Journal of Cardio-thoracic Surgery, Vol. 50, No. 5, 2016, p. 882-889.

Research output: Contribution to journalArticle

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title = "Long-term results of mitral repair in patients with severe left ventricular dysfunction and secondary mitral regurgitation: does the technique matter?",
abstract = "OBJECTIVES: An isolated undersized annuloplasty was used to treat mitral regurgitation (MR) secondary to dilated cardiomyopathy (DCM) if the baseline coaptation depth (CD) was /=1 cm), the edge-to-edge (EE) technique was combined with annuloplasty to improve the durability of the repair. The long-term results of this approach are unknown and represent the objective of this study. METHODS: To obtain long-term outcome data, we included in the study population the first 105 consecutive patients with severe left ventricular dysfunction (ejection fraction 29 +/- 6.6{\%}) and secondary MR submitted to mitral valve repair. Forty patients underwent isolated undersized annuloplasty and 65 patients received the EE technique combined with annuloplasty. Preoperative and postoperative data were prospectively entered into a dedicated database. Clinical and echocardiographic follow-ups were performed in our institutional outpatient clinic. RESULTS: Follow-up was 90{\%} complete. The median follow-up time was 7.2 years (interquartile range 4.3;10.4). The longest follow-up time was 16.5 years. A comparative analysis between the annuloplasty group and the EE group was performed. Baseline LV dimensions and function were slightly worse in the EE group, but only the severity of tethering was significantly more pronounced than in the annuloplasty group. Hospital mortality (3 vs 2.5{\%}, P = 1.0) and 10-year overall survival (42 +/- 6.7 vs 55 +/- 8.5{\%}, P = 0.2) were not significantly different in the EE and annuloplasty group, respectively. Cumulative incidence functions of cardiac death were similar as well (at 10-years, 34.3 +/- 8.1 vs 37.9 +/- 6.4{\%}, respectively, P = 0.4). At 10 years, cumulative incidence function of recurrence of MR >/=3+ was lower in the EE patients (10.3 +/- 4.1 vs 30.8+/-8.0{\%}, P = 0.01). Isolated annuloplasty [hazard ratio (HR) 4.84, 95{\%} confidence interval (CI) 1.46-16.1, P = 0.01] and residual MR >1+ at hospital discharge (HR 5.25, 95{\%} CI 2.00-13.8, P /=3. Failure of repair was associated with recurrence of New York Heart Association III or IV symptoms (P <0.001). CONCLUSIONS: In patients with end-stage DCM and secondary MR, the association of the EE technique to the undersized annuloplasty significantly decreases the rate of recurrent MR at long-term. This higher repair durability did not translate into a better long-term prognosis in this series.",
keywords = "Edge-to-edge repair, Mitral valve repair, Secondary mitral regurgitation, Undersized annuloplasty",
author = "{De Bonis}, M. and Elizabeth Lapenna and Fabio Barili and Teodora Nisi and M. Calabrese and F. Pappalardo and {La Canna}, G. and Pozzoli, {G. A.} and Nicola Buzzatti and A. Giacomini and Emanuela Alati and O. Alfieri",
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TY - JOUR

T1 - Long-term results of mitral repair in patients with severe left ventricular dysfunction and secondary mitral regurgitation: does the technique matter?

AU - De Bonis, M.

AU - Lapenna, Elizabeth

AU - Barili, Fabio

AU - Nisi, Teodora

AU - Calabrese, M.

AU - Pappalardo, F.

AU - La Canna, G.

AU - Pozzoli, G. A.

AU - Buzzatti, Nicola

AU - Giacomini, A.

AU - Alati, Emanuela

AU - Alfieri, O.

N1 - LR: 20170208; CI: (c) The Author 2016; JID: 8804069; OTO: NOTNLM; 2015/09/15 [received]; 2016/03/04 [accepted]; ppublish M1 - Journal Article

PY - 2016

Y1 - 2016

N2 - OBJECTIVES: An isolated undersized annuloplasty was used to treat mitral regurgitation (MR) secondary to dilated cardiomyopathy (DCM) if the baseline coaptation depth (CD) was /=1 cm), the edge-to-edge (EE) technique was combined with annuloplasty to improve the durability of the repair. The long-term results of this approach are unknown and represent the objective of this study. METHODS: To obtain long-term outcome data, we included in the study population the first 105 consecutive patients with severe left ventricular dysfunction (ejection fraction 29 +/- 6.6%) and secondary MR submitted to mitral valve repair. Forty patients underwent isolated undersized annuloplasty and 65 patients received the EE technique combined with annuloplasty. Preoperative and postoperative data were prospectively entered into a dedicated database. Clinical and echocardiographic follow-ups were performed in our institutional outpatient clinic. RESULTS: Follow-up was 90% complete. The median follow-up time was 7.2 years (interquartile range 4.3;10.4). The longest follow-up time was 16.5 years. A comparative analysis between the annuloplasty group and the EE group was performed. Baseline LV dimensions and function were slightly worse in the EE group, but only the severity of tethering was significantly more pronounced than in the annuloplasty group. Hospital mortality (3 vs 2.5%, P = 1.0) and 10-year overall survival (42 +/- 6.7 vs 55 +/- 8.5%, P = 0.2) were not significantly different in the EE and annuloplasty group, respectively. Cumulative incidence functions of cardiac death were similar as well (at 10-years, 34.3 +/- 8.1 vs 37.9 +/- 6.4%, respectively, P = 0.4). At 10 years, cumulative incidence function of recurrence of MR >/=3+ was lower in the EE patients (10.3 +/- 4.1 vs 30.8+/-8.0%, P = 0.01). Isolated annuloplasty [hazard ratio (HR) 4.84, 95% confidence interval (CI) 1.46-16.1, P = 0.01] and residual MR >1+ at hospital discharge (HR 5.25, 95% CI 2.00-13.8, P /=3. Failure of repair was associated with recurrence of New York Heart Association III or IV symptoms (P <0.001). CONCLUSIONS: In patients with end-stage DCM and secondary MR, the association of the EE technique to the undersized annuloplasty significantly decreases the rate of recurrent MR at long-term. This higher repair durability did not translate into a better long-term prognosis in this series.

AB - OBJECTIVES: An isolated undersized annuloplasty was used to treat mitral regurgitation (MR) secondary to dilated cardiomyopathy (DCM) if the baseline coaptation depth (CD) was /=1 cm), the edge-to-edge (EE) technique was combined with annuloplasty to improve the durability of the repair. The long-term results of this approach are unknown and represent the objective of this study. METHODS: To obtain long-term outcome data, we included in the study population the first 105 consecutive patients with severe left ventricular dysfunction (ejection fraction 29 +/- 6.6%) and secondary MR submitted to mitral valve repair. Forty patients underwent isolated undersized annuloplasty and 65 patients received the EE technique combined with annuloplasty. Preoperative and postoperative data were prospectively entered into a dedicated database. Clinical and echocardiographic follow-ups were performed in our institutional outpatient clinic. RESULTS: Follow-up was 90% complete. The median follow-up time was 7.2 years (interquartile range 4.3;10.4). The longest follow-up time was 16.5 years. A comparative analysis between the annuloplasty group and the EE group was performed. Baseline LV dimensions and function were slightly worse in the EE group, but only the severity of tethering was significantly more pronounced than in the annuloplasty group. Hospital mortality (3 vs 2.5%, P = 1.0) and 10-year overall survival (42 +/- 6.7 vs 55 +/- 8.5%, P = 0.2) were not significantly different in the EE and annuloplasty group, respectively. Cumulative incidence functions of cardiac death were similar as well (at 10-years, 34.3 +/- 8.1 vs 37.9 +/- 6.4%, respectively, P = 0.4). At 10 years, cumulative incidence function of recurrence of MR >/=3+ was lower in the EE patients (10.3 +/- 4.1 vs 30.8+/-8.0%, P = 0.01). Isolated annuloplasty [hazard ratio (HR) 4.84, 95% confidence interval (CI) 1.46-16.1, P = 0.01] and residual MR >1+ at hospital discharge (HR 5.25, 95% CI 2.00-13.8, P /=3. Failure of repair was associated with recurrence of New York Heart Association III or IV symptoms (P <0.001). CONCLUSIONS: In patients with end-stage DCM and secondary MR, the association of the EE technique to the undersized annuloplasty significantly decreases the rate of recurrent MR at long-term. This higher repair durability did not translate into a better long-term prognosis in this series.

KW - Edge-to-edge repair

KW - Mitral valve repair

KW - Secondary mitral regurgitation

KW - Undersized annuloplasty

M3 - Article

VL - 50

SP - 882

EP - 889

JO - European Journal of Cardio-thoracic Surgery

JF - European Journal of Cardio-thoracic Surgery

SN - 1010-7940

IS - 5

ER -