Long-term results of primary surgery for stage I small cell lung cancer

G. Rocco, M. Tondini, F. Massera, G. Rossi, C. Della Pono, M. Robustellini, A. Rizzi

Research output: Contribution to journalArticlepeer-review

Abstract

Between January 1979, and December 1993, 17 patients (15 females and 2 males; mean age 57.9 ± 2.8 (SEM) yrs., median 55 yrs, (range 43-78) with stage I small-cell lung cancer underwent primary surgery followed by adjuvant polychemotherapy and prophylactic cranial irradiation. In no instance was preoperative histological diagnosis available. The extent of resection included a lobectomy in 9 patients, a pneumonectomy in 1, and a segmental resection in 7. Postoperative chemotherapy included three cycles of cyclophosphamide - 1000 mg/m2, vincristine - 1.3 mg/m2, doxorubicin or epidoxorubicin - 60 mg/m2, administered every 21 days, followed by three additional cycles of cisplatin - 25 mg/m2, and VP16-120 mg/m2, administered in 3 consecutive days every 21-28 days. Prophylactic cranial irradiaton was given concurrently with the first cycle of chemotherapy and immediately after surgery. Actuarial 5-year survival was 47% (Kaplan-Meier method). Median survival was 61 months. No statistically significant difference in terms of survival was detected between lobectomy and other procedures (p = 0.2, log-rank test).

Original languageEnglish
Pages (from-to)365-368
Number of pages4
JournalRadiology and Oncology
Volume28
Issue number4
Publication statusPublished - 1994

Keywords

  • carcinoma, oat cell, survival analysis
  • lung neoplasms-surgery

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

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