Between January 1979, and December 1993, 17 patients (15 females and 2 males; mean age 57.9 ± 2.8 (SEM) yrs., median 55 yrs, (range 43-78) with stage I small-cell lung cancer underwent primary surgery followed by adjuvant polychemotherapy and prophylactic cranial irradiation. In no instance was preoperative histological diagnosis available. The extent of resection included a lobectomy in 9 patients, a pneumonectomy in 1, and a segmental resection in 7. Postoperative chemotherapy included three cycles of cyclophosphamide - 1000 mg/m2, vincristine - 1.3 mg/m2, doxorubicin or epidoxorubicin - 60 mg/m2, administered every 21 days, followed by three additional cycles of cisplatin - 25 mg/m2, and VP16-120 mg/m2, administered in 3 consecutive days every 21-28 days. Prophylactic cranial irradiaton was given concurrently with the first cycle of chemotherapy and immediately after surgery. Actuarial 5-year survival was 47% (Kaplan-Meier method). Median survival was 61 months. No statistically significant difference in terms of survival was detected between lobectomy and other procedures (p = 0.2, log-rank test).
|Number of pages||4|
|Journal||Radiology and Oncology|
|Publication status||Published - 1994|
- carcinoma, oat cell, survival analysis
- lung neoplasms-surgery
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging