Between 1985 and 1989, 22 patients with metastatic urothelial cancer (18 bladder, 3 upper urinary tract and 1 urethra) were treated with 4 courses of 'simplified' M-VAC combination chemotherapy (omission of therapy on day 22). Therapy could be recycled every 4 weeks in all cases, and on day 15 had to be omitted only in 12% of courses, hematologic toxicity was moderate and non significant renal toxicity occurred. Six patients (28%) presented complete remission and 9 (40%) were partial responders. Four patients (18%) are still alive and are disease-free after 45 to 60 months. Omission of therapy on day 22 in M-VAC combination chemotherapy makes the treatment tolerable, while activity seems to be unchanged, probably because patients can respect the schedule.
|Translated title of the contribution||Long-term results of simplified M-VAC chemotherapy in metastatic urothelial cancer|
|Number of pages||2|
|Journal||Acta Urologica Italica|
|Issue number||SUPPL. 2|
|Publication status||Published - 1993|
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