Long-term results of surgical management of pulmonary metastases from renal cell carcinoma

G. Marulli, F. Sartori, P. F. Bassi, F. Dal Moro, A. Gino Favaretto, Federico Rea

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Metastatic renal cell carcinoma (RCC) has a poor prognosis and conventional treatments such as chemoradiotherapy show little efficacy. Surgical resection of pulmonary metastases from RCC is a widely accepted treatment, even if selection criteria based on prognostic factors have still not been defined. The aim of this study was to determine the long-term survival, clinical outcome and prognostic factors after surgery. Methods: Between 1988 and 2004, 59 patients underwent resection of pulmonary metastases from RCC. Univariate and multivariate analysis of prognostic factors was carried out. Results: Complete resection was achieved in 54 (91.5%) patients. No intra- or postoperative mortality occurred, 5 (8.5%) patients experienced postoperative complications. Overall, the 1-, 3-, and 5-year survival rates were 86.5%, 63% and 53%, respectively. Age at the time of pulmonary resection was found to be the only independent factor influencing prognosis. Conclusion: Pulmonary resection of metastases from RCC is a safe and effective treatment associated with a low morbidity and mortality and with high long-term survival. The lack of other effective therapies suggests use of the surgical approach whenever possible.

Original languageEnglish
Pages (from-to)544-547
Number of pages4
JournalThoracic and Cardiovascular Surgeon
Volume54
Issue number8
DOIs
Publication statusPublished - Dec 2006

Keywords

  • Nephrectomy
  • Pulmonary metastases
  • Renal cell carcinoma
  • Surgical resection

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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