Long-term safety of fertility sparing surgery in early stage ovarian cancer: Comparison to standard radical surgical procedures

Antonino Ditto, Fabio Martinelli, Giorgio Bogani, Domenica Lorusso, Marialuisa Carcangiu, Valentina Chiappa, Claudio Reato, Cristina Donfrancesco, Karla Jeanette Amaya De Carrillo, Francesco Raspagliesi

Research output: Contribution to journalArticle

Abstract

Objective Fertility-sparing surgery (FSS) is a strategy often considered in young patients with low-grade (G1-2) early-stage epithelial ovarian cancer (eEOC), while is still controversial in high-risk patients. We investigated the role of FSS in low and high-risk eEOC patients undergoing comprehensive surgical staging. Methods We analyzed data from patients operated for an eEOC from 1975 to 2011, focusing on patients submitted to FSS. Seventy patients out of 307 with eEOC were identified. Patients underwent FSS were compared with 237 patients underwent radical-comprehensive-staging (RCS) in the same period. Disease free (DFS) and overall (OS) survivals were evaluated using Kaplan-Meier and Cox models. Results Overall, 307 patients had surgery for eEOC: 70 (22.8%) and 237 (77.2%) women had FSS and RCS, respectively. At univariate analysis, the execution of FSS not influenced DFS (HR:1.06 (95%CI: 0.56,2.02); p = 0.84) and OS (HR:1.94 (95%CI: 0.75,4.98); p = 0.16). Stage of disease was the only factor correlating with DFS (HR:4.73; 95%CI: 2.01,11.11; p <0.001). Independently, increased age (HR per 1-unit of age:1.06 (95%CI: 1.03,1.11); p <0.001) and high risk disease (HR:3.26; 95%CI: 1.23,8.62; p = 0.01) remained associated with worse OS. Focusing on the high risk group (stage IAG3 or more) we observed that type of surgery (FSS v. RCS) did not influence DFS (p = 0.77, log-rank test) and OS (p = 0.08, log-rank test). Conclusions FSS upholds oncologic effectiveness of RCS, preserving reproductive and endocrine functions. FSS does not increase risk of recurrence among high risk eEOC patients. Further prospective studies on this issue are warranted to improve patients' care.

Original languageEnglish
Pages (from-to)78-82
Number of pages5
JournalGynecologic Oncology
Volume138
Issue number1
DOIs
Publication statusPublished - Jul 1 2015

Keywords

  • Fertility-sparing
  • Lymphadenectomy
  • Ovarian cancer
  • Survival
  • Upstaging

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology

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