Long-term Saxagliptin Treatment Improves Endothelial Function but not Pulse Wave Velocity and Intima-Media Thickness in Type 2 Diabetic Patients

Raffaella Dell’Oro, Alessandro Maloberti, Francesco Nicoli, Paolo Villa, Pierluigi Gamba, Michele Bombelli, Giuseppe Mancia, Guido Grassi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Introduction: Pharmacological inhibition of dipeptidyl-peptidase-4 may represent a promising therapeutic approach for glucose control and vascular protection. No information is available on the effects of saxagliptin (S) on aortic pulse wave velocity, carotid intima-media thickness and flow-mediated dilation (FMD, brachial artery) in diabetes. Aim: We investigated the long-term effects of S, as add-on therapy to metformin, on the above mentioned variables. Methods: In 16 patients with decompensated diabetes aortic pulse wave velocity, carotid intima-media thickness and FMD, office and 24-h ambulatory blood pressure, anthropometric, biochemical and metabolic parameters were measured at baseline and after 6 and 12 months of treatment. A group of 16 compensated diabetics served as controls. Results: The two groups showed superimposable values of the different parameters, with the exception of glycated hemoglobin, blood glucose significantly (P < 0.05) greater in the S-treated patients. In the S-group glucose metabolism and FMD significantly improved during the follow-up (from 169.3 ± 8 to 157.1 ± 9 mg/dl, P < 0.05, from 7.9 ± 0.1 to 6.9 ± 0.2%, P < 0.001 and from 3.6 ± 0.3 to 7.4 ± 0.8%, respectively P < 0.05). No significant difference was detected in the other parameters, including blood pressure. Conclusions: Thus treatment with S added-on to metformin results in beneficial effects on endothelial function, related at least in part to the concomitant improvement in glucose metabolism. This may represent a first step in the chain of events leading to a reduction in the progression of the vascular atherogenic process.

Original languageEnglish
Pages (from-to)393-400
Number of pages8
JournalHigh Blood Pressure and Cardiovascular Prevention
Volume24
Issue number4
DOIs
Publication statusPublished - Dec 1 2017

Fingerprint

Pulse Wave Analysis
Carotid Intima-Media Thickness
Metformin
Glucose
Blood Vessels
Blood Pressure
Dipeptidyl Peptidase 4
Brachial Artery
Glycosylated Hemoglobin A
Therapeutics
Blood Glucose
Dilatation
Pharmacology
saxagliptin

Keywords

  • Arterial stiffness
  • Endothelial function
  • Inhibitors of dipeptidyl-peptidase-4
  • Saxagliptin
  • Shear stress
  • Ultrasonography

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Long-term Saxagliptin Treatment Improves Endothelial Function but not Pulse Wave Velocity and Intima-Media Thickness in Type 2 Diabetic Patients. / Dell’Oro, Raffaella; Maloberti, Alessandro; Nicoli, Francesco; Villa, Paolo; Gamba, Pierluigi; Bombelli, Michele; Mancia, Giuseppe; Grassi, Guido.

In: High Blood Pressure and Cardiovascular Prevention, Vol. 24, No. 4, 01.12.2017, p. 393-400.

Research output: Contribution to journalArticle

Dell’Oro, Raffaella ; Maloberti, Alessandro ; Nicoli, Francesco ; Villa, Paolo ; Gamba, Pierluigi ; Bombelli, Michele ; Mancia, Giuseppe ; Grassi, Guido. / Long-term Saxagliptin Treatment Improves Endothelial Function but not Pulse Wave Velocity and Intima-Media Thickness in Type 2 Diabetic Patients. In: High Blood Pressure and Cardiovascular Prevention. 2017 ; Vol. 24, No. 4. pp. 393-400.
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AU - Nicoli, Francesco

AU - Villa, Paolo

AU - Gamba, Pierluigi

AU - Bombelli, Michele

AU - Mancia, Giuseppe

AU - Grassi, Guido

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