Long-term selective IgG immunoadsorption improves Rasmussen's encephalitis

Carlo Antozzi, T. Granata, N. Aurisano, G. Zardini, P. Confalonieri, G. Airaghi, R. Mantegazza, R. Spreafico

Research output: Contribution to journalArticle

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Abstract

We report that long-term selective immunoglobulin G immunoadsorption by protein A (PAI) improved seizure frequency and neuropsychological deficits in a 16-year-old patient with severe treatment-resistant Rasmussen's encephalitis (RE). Clinical improvement correlated with reduction of antiglutamate receptor 3 antibodies. The efficacy of PAI in our patient supports the autoimmune hypothesis of RE and suggests its application to avoid, or at least delay, functional hemispherectomy in selected cases.

Original languageEnglish
Pages (from-to)302-305
Number of pages4
JournalNeurology
Volume51
Issue number1
Publication statusPublished - Jul 1998

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Encephalitis
Immunoglobulin G
Hemispherectomy
Staphylococcal Protein A
Seizures
Antibodies
Therapeutics

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Antozzi, C., Granata, T., Aurisano, N., Zardini, G., Confalonieri, P., Airaghi, G., ... Spreafico, R. (1998). Long-term selective IgG immunoadsorption improves Rasmussen's encephalitis. Neurology, 51(1), 302-305.

Long-term selective IgG immunoadsorption improves Rasmussen's encephalitis. / Antozzi, Carlo; Granata, T.; Aurisano, N.; Zardini, G.; Confalonieri, P.; Airaghi, G.; Mantegazza, R.; Spreafico, R.

In: Neurology, Vol. 51, No. 1, 07.1998, p. 302-305.

Research output: Contribution to journalArticle

Antozzi, C, Granata, T, Aurisano, N, Zardini, G, Confalonieri, P, Airaghi, G, Mantegazza, R & Spreafico, R 1998, 'Long-term selective IgG immunoadsorption improves Rasmussen's encephalitis', Neurology, vol. 51, no. 1, pp. 302-305.
Antozzi, Carlo ; Granata, T. ; Aurisano, N. ; Zardini, G. ; Confalonieri, P. ; Airaghi, G. ; Mantegazza, R. ; Spreafico, R. / Long-term selective IgG immunoadsorption improves Rasmussen's encephalitis. In: Neurology. 1998 ; Vol. 51, No. 1. pp. 302-305.
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