TY - JOUR
T1 - Long-term stability of relationships between reference materials for thromboplastins
AU - Linsinger, Thomas P J
AU - van den Besselaar, Anton M H P
AU - Tripodi, Armando
PY - 2006/8
Y1 - 2006/8
N2 - Reference materials for thromboplastins are available from the World Health Organization (WHO) and the European Commission (EC). The long-term stability of the reference materials is an essential requirement and must be monitored. The relationship between two reference materials for rabbit thromboplastin, i.e. ERM-AD 149 (EC) and RBT/90 (WHO), has been monitored in the period 1996-2002. No significant trend with time was detected. In addition, the relationship between ERM-AD 149 and the reference material for bovine thromboplastin (i.e. OBT/79) has been determined in 1994 and in 2005 in multi-centre studies (n = 11 and n = 9, respectively). No significant changes were observed in the relationship between these reference materials when all results were included (5% significance level).
AB - Reference materials for thromboplastins are available from the World Health Organization (WHO) and the European Commission (EC). The long-term stability of the reference materials is an essential requirement and must be monitored. The relationship between two reference materials for rabbit thromboplastin, i.e. ERM-AD 149 (EC) and RBT/90 (WHO), has been monitored in the period 1996-2002. No significant trend with time was detected. In addition, the relationship between ERM-AD 149 and the reference material for bovine thromboplastin (i.e. OBT/79) has been determined in 1994 and in 2005 in multi-centre studies (n = 11 and n = 9, respectively). No significant changes were observed in the relationship between these reference materials when all results were included (5% significance level).
KW - Calibration
KW - Reference material
KW - Stability
KW - Thromboplastin
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U2 - 10.1160/TH06-03-0152
DO - 10.1160/TH06-03-0152
M3 - Article
C2 - 16894466
AN - SCOPUS:33747147412
VL - 96
SP - 210
EP - 214
JO - Thrombosis and Haemostasis
JF - Thrombosis and Haemostasis
SN - 0340-6245
IS - 2
ER -