Long-term stability of relationships between reference materials for thromboplastins

Thomas P J Linsinger, Anton M H P van den Besselaar, Armando Tripodi

Research output: Contribution to journalArticlepeer-review


Reference materials for thromboplastins are available from the World Health Organization (WHO) and the European Commission (EC). The long-term stability of the reference materials is an essential requirement and must be monitored. The relationship between two reference materials for rabbit thromboplastin, i.e. ERM-AD 149 (EC) and RBT/90 (WHO), has been monitored in the period 1996-2002. No significant trend with time was detected. In addition, the relationship between ERM-AD 149 and the reference material for bovine thromboplastin (i.e. OBT/79) has been determined in 1994 and in 2005 in multi-centre studies (n = 11 and n = 9, respectively). No significant changes were observed in the relationship between these reference materials when all results were included (5% significance level).

Original languageEnglish
Pages (from-to)210-214
Number of pages5
JournalThrombosis and Haemostasis
Issue number2
Publication statusPublished - Aug 2006


  • Calibration
  • Reference material
  • Stability
  • Thromboplastin

ASJC Scopus subject areas

  • Hematology


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