TY - JOUR
T1 - Long-term survival and prognostic factors in the surgical treatment of mass-forming type cholangiocarcinoma
AU - Inoue, Kazuto
AU - Makuuchi, Masatoshi
AU - Takayama, Tadatoshi
AU - Torzilli, Guido
AU - Yamamoto, Junji
AU - Shimada, Kazuaki
AU - Kosuge, Tomoo
AU - Yamasaki, Susumu
AU - Konishi, Masaru
AU - Kinoshita, Taira
AU - Miyagawa, Shinichi
AU - Kawasaki, Seiji
PY - 2000
Y1 - 2000
N2 - Background. Mass-forming type cholangiocarcinoma is a distinct form of cholangiocellular carcinoma, with pathologic and biologic behavior different from those of other types. The clinical consequences of these differences have never been clarified. Methods. Fifty-two consecutive patients (32 men and 20 women, mean age 62 years) with mass-forming type cholangiocarcinoma that had been treated with curative surgical resection between 1980 and 1998 were retrospectively evaluated. Long-term survival and disease-free survival were calculated, and univariate and multivariate analysis of various prognostic factors was conducted. Results. The 30-day postoperative mortality rate was 2%, and the overall and disease-free 5-year survival rates were 36% and 34%, respectively. Univariate analysis identified 5 significant risk factors for overall survival: surgical margin, lymph node metastasis, lymph node dissection, vascular invasion, and left-side location of the main tumor. Two risk factors were identified for disease-free survival: surgical margin and lymph node metastasis. Multivariate analysis confirmed that surgical margin, lymph node metastasis, and vascular invasion were independently significant variables for overall survival. Conclusions. This is the first reported study on the effectiveness of liver resection for the treatment of mass-forming type cholangiocarcinoma, showing that surgical therapy can prolong survival if local radicality can be achieved and lymph-node metastases are absent.
AB - Background. Mass-forming type cholangiocarcinoma is a distinct form of cholangiocellular carcinoma, with pathologic and biologic behavior different from those of other types. The clinical consequences of these differences have never been clarified. Methods. Fifty-two consecutive patients (32 men and 20 women, mean age 62 years) with mass-forming type cholangiocarcinoma that had been treated with curative surgical resection between 1980 and 1998 were retrospectively evaluated. Long-term survival and disease-free survival were calculated, and univariate and multivariate analysis of various prognostic factors was conducted. Results. The 30-day postoperative mortality rate was 2%, and the overall and disease-free 5-year survival rates were 36% and 34%, respectively. Univariate analysis identified 5 significant risk factors for overall survival: surgical margin, lymph node metastasis, lymph node dissection, vascular invasion, and left-side location of the main tumor. Two risk factors were identified for disease-free survival: surgical margin and lymph node metastasis. Multivariate analysis confirmed that surgical margin, lymph node metastasis, and vascular invasion were independently significant variables for overall survival. Conclusions. This is the first reported study on the effectiveness of liver resection for the treatment of mass-forming type cholangiocarcinoma, showing that surgical therapy can prolong survival if local radicality can be achieved and lymph-node metastases are absent.
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M3 - Article
C2 - 10819057
AN - SCOPUS:0034112844
VL - 127
SP - 498
EP - 505
JO - Surgery
JF - Surgery
SN - 0039-6060
IS - 5
ER -