Long-term survival and prognostic factors in the surgical treatment of mass-forming type cholangiocarcinoma

Kazuto Inoue, Masatoshi Makuuchi, Tadatoshi Takayama, Guido Torzilli, Junji Yamamoto, Kazuaki Shimada, Tomoo Kosuge, Susumu Yamasaki, Masaru Konishi, Taira Kinoshita, Shinichi Miyagawa, Seiji Kawasaki

Research output: Contribution to journalArticle

Abstract

Background. Mass-forming type cholangiocarcinoma is a distinct form of cholangiocellular carcinoma, with pathologic and biologic behavior different from those of other types. The clinical consequences of these differences have never been clarified. Methods. Fifty-two consecutive patients (32 men and 20 women, mean age 62 years) with mass-forming type cholangiocarcinoma that had been treated with curative surgical resection between 1980 and 1998 were retrospectively evaluated. Long-term survival and disease-free survival were calculated, and univariate and multivariate analysis of various prognostic factors was conducted. Results. The 30-day postoperative mortality rate was 2%, and the overall and disease-free 5-year survival rates were 36% and 34%, respectively. Univariate analysis identified 5 significant risk factors for overall survival: surgical margin, lymph node metastasis, lymph node dissection, vascular invasion, and left-side location of the main tumor. Two risk factors were identified for disease-free survival: surgical margin and lymph node metastasis. Multivariate analysis confirmed that surgical margin, lymph node metastasis, and vascular invasion were independently significant variables for overall survival. Conclusions. This is the first reported study on the effectiveness of liver resection for the treatment of mass-forming type cholangiocarcinoma, showing that surgical therapy can prolong survival if local radicality can be achieved and lymph-node metastases are absent.

Original languageEnglish
Pages (from-to)498-505
Number of pages8
JournalSurgery
Volume127
Issue number5
Publication statusPublished - 2000

    Fingerprint

ASJC Scopus subject areas

  • Surgery

Cite this

Inoue, K., Makuuchi, M., Takayama, T., Torzilli, G., Yamamoto, J., Shimada, K., Kosuge, T., Yamasaki, S., Konishi, M., Kinoshita, T., Miyagawa, S., & Kawasaki, S. (2000). Long-term survival and prognostic factors in the surgical treatment of mass-forming type cholangiocarcinoma. Surgery, 127(5), 498-505.