Long-term survival benefit of coronary revascularization in patients undergoing stress myocardial perfusion imaging

Mario Petretta, Wanda Acampa, Stefania Daniele, Emilia Zampella, Roberta Assante, Carmela Nappi, Marco Salvatore, Alberto Cuocolo

Research output: Contribution to journalArticlepeer-review

Abstract

Background: We assessed the relationship between clinical outcome and coronary revascularization according to stress-gated myocardial perfusion single-photon emission computed tomography (MPS) in an observational series of patients with suspected or known coronary artery disease (CAD), on long-term follow-up. Methods and Results: The study group consisted of 2,059 patients. During a median follow-up of 61 months, 184 events occurred (126 cardiac deaths and 58 non-fatal MI). The impact of revascularization during follow-up on event-free survival was evaluated using an extended Cox regression model, adjusting for potential clinical and MPS confounders. Revascularization was treated as a binary non-reversible time-dependent covariate. Predefined interactions tested were: (1) revascularization and summed difference score (SDS); (2) revascularization and post-stress left ventricular (LV) ejection fraction (EF); and (3) SDS and post-stress LVEF. Revascularization had a significant effect on event-free survival (adjusted HR, 0.19; P

Original languageEnglish
Pages (from-to)485-493
Number of pages9
JournalCirculation Journal
Volume80
Issue number2
DOIs
Publication statusPublished - Jan 25 2016

Keywords

  • Coronary revascularization
  • Imaging
  • Prognosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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