CARATTERISTICHE DEI LUNGO SOPRAVVIVENTI DOPO CHEMIOTERAPIA NELLE RECIDIVE DEI CARDINOMI DELA TESTA E DEL COLLO

Translated title of the contribution: Long-term survival following chemotherapy for recurrent head and neck cancer: Patient characteristics

M. Airoldi, C. Bumma, G. Cortesina, C. Giordano, M. Bussi, R. Orecchia, G. Succo, P. Gabriele, O. Bertetto

Research output: Contribution to journalArticle

Abstract

Eighty-one patients with recurrent squamous cell carcinoma of the head and neck (60 patients) or undifferentiated carcinoma of the nasopharyngeal type (21 patients) were treated with cisplatin (80-100 mg/m2 iv d1) and 5-fluorouracil (750-1000 mg/m2 Cl d1-5). In squamous cell carcinoma patients there were 7 complete responses (11.6%), 25 partial responses (41.7%), 20 stable disease situations (33.3%) and 8 progressions (13.3%). In nasopharyngeal carcinoma patients there were 6 complete responses (28.6%), 9 partial responses (42.8%), 3 stable disease situations (14.3%) and 3 progression (14.3%). There were 5/60 patients (8.3%) with disease-free survival > 18 months in the squamous cell carcinoma group and 2/21 (9%) in the nasopharyngeal carcinoma group. All long-term survival patients had the following characteristics: good performance status (0-1 ECOG scale), disease-free interval from the first treatment > 12 months, local non-bulky relapse (rT1-2). A re-irradiation with palliative doses (20-48 Gy) was conducted in 3/7 patients. This treatment may have improved the response to drugs with regard to length and quality.

Translated title of the contributionLong-term survival following chemotherapy for recurrent head and neck cancer: Patient characteristics
Original languageItalian
Pages (from-to)603-609
Number of pages7
JournalActa Otorhinolaryngologica Italica
Volume14
Issue number6
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Otorhinolaryngology

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