Long-term survival in adult acute leukemia. A multicenter study of 56 patients

S. Tura, M. Gobbi, M. Cavo, G. Bachetti, F. Mandelli, S. Amadori, M. C. Petti, N. Quattrin, L. De Rosa, E. Storti, S. C. Rizzo, C. Bernasconi, L. Salvaneschi, W. Paolino, V. Infelise, E. Dini, T. Barbui, L. Bruzzese, A. Abbadessa, M. F. MartelliP. Rambotti

Research output: Contribution to journalArticlepeer-review


Fifty-six adult AL patients (20 ANLL and 36 ALL), collected in 9 Italian centres, who survived for more than 5 years, were analysed with the aim of identifying the factors correlated with such a favourable outcome of the disease. The 56 long term survivors were compared with 118 AL patients (86 ANLL and 32 ALL) treated at one of the centres (Bologna) who had a more usual outcome of the disease. No statistically significant differences were recorded between long term and standard survivors, with either ANLL or ALL, relative to sex, hemoglobin level, WBC, blast and platelet counts. In addition, the clinical findings at the onset of the disease were similar in long term and standard survivors. ANLL long term survival patients greatly differed regarding type and duration of induction and maintenance chemotherapy; on the contrary, treatment administered to ALL long term survivors was more uniform and consisted of VCR + P as induction therapy and 6-MP and MTX as maintenance therapy. From analysis of our data, no factor correlated with long term survival was identified.

Original languageEnglish
Pages (from-to)368-383
Number of pages16
Issue number3
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Hematology


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