TY - JOUR
T1 - Long-term survival in patients presenting with type B acute aortic dissection
T2 - Insights from the international registry of acute aortic dissection
AU - Tsai, Thomas T.
AU - Fattori, Rossella
AU - Trimarchi, Santi
AU - Isselbacher, Eric
AU - Myrmel, Truls
AU - Evangelista, Arturo
AU - Hutchison, Stuart
AU - Sechtem, Udo
AU - Cooper, Jeanna V.
AU - Smith, Dean E.
AU - Pape, Linda
AU - Froehlich, James
AU - Raghupathy, Arun
AU - Januzzi, James L.
AU - Eagle, Kim A.
AU - Nienaber, Christoph A.
PY - 2006/11
Y1 - 2006/11
N2 - BACKGROUND - Follow-up survival studies in patients with acute type B aortic dissection have been restricted to a small number of patients in single centers. We used data from a contemporary registry of acute type B aortic dissection to better understand factors associated with adverse long-term survival. METHODS AND RESULTS - We examined 242 consecutive patients discharged alive with acute type B aortic dissection enrolled in the International Registry of Acute Aortic Dissection (IRAD) between 1996 and 2003. Kaplan-Meier survival curves were constructed, and Cox proportional hazards analysis was performed to identify independent predictors of follow-up mortality. Three-year survival for patients treated medically, surgically, or with endovascular therapy was 77.6±6.6%, 82.8±18.9%, and 76.2±25.2%, respectively (median follow-up 2.3 years, log-rank P=0.61). Independent predictors of follow-up mortality included female gender (hazard ratio [HR], 1.99; 95% confidence interval [CI], 1.07 to 3.71; P=0.03), a history of prior aortic aneurysm (HR, 2.17; 95% CI, 1.03 to 4.59; P=0.04), a history of atherosclerosis (HR, 2.48; 95% CI, 1.32 to 4.66; P
AB - BACKGROUND - Follow-up survival studies in patients with acute type B aortic dissection have been restricted to a small number of patients in single centers. We used data from a contemporary registry of acute type B aortic dissection to better understand factors associated with adverse long-term survival. METHODS AND RESULTS - We examined 242 consecutive patients discharged alive with acute type B aortic dissection enrolled in the International Registry of Acute Aortic Dissection (IRAD) between 1996 and 2003. Kaplan-Meier survival curves were constructed, and Cox proportional hazards analysis was performed to identify independent predictors of follow-up mortality. Three-year survival for patients treated medically, surgically, or with endovascular therapy was 77.6±6.6%, 82.8±18.9%, and 76.2±25.2%, respectively (median follow-up 2.3 years, log-rank P=0.61). Independent predictors of follow-up mortality included female gender (hazard ratio [HR], 1.99; 95% confidence interval [CI], 1.07 to 3.71; P=0.03), a history of prior aortic aneurysm (HR, 2.17; 95% CI, 1.03 to 4.59; P=0.04), a history of atherosclerosis (HR, 2.48; 95% CI, 1.32 to 4.66; P
KW - Aorta
KW - Follow-up studies
KW - Mortality
KW - Risk factors
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U2 - 10.1161/CIRCULATIONAHA.106.622340
DO - 10.1161/CIRCULATIONAHA.106.622340
M3 - Article
C2 - 17101856
AN - SCOPUS:33751255665
VL - 114
SP - 2226
EP - 2231
JO - Circulation
JF - Circulation
SN - 0009-7322
IS - 21
ER -