Long-term survival in patients presenting with type B acute aortic dissection: Insights from the international registry of acute aortic dissection

Thomas T. Tsai, Rossella Fattori, Santi Trimarchi, Eric Isselbacher, Truls Myrmel, Arturo Evangelista, Stuart Hutchison, Udo Sechtem, Jeanna V. Cooper, Dean E. Smith, Linda Pape, James Froehlich, Arun Raghupathy, James L. Januzzi, Kim A. Eagle, Christoph A. Nienaber

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND - Follow-up survival studies in patients with acute type B aortic dissection have been restricted to a small number of patients in single centers. We used data from a contemporary registry of acute type B aortic dissection to better understand factors associated with adverse long-term survival. METHODS AND RESULTS - We examined 242 consecutive patients discharged alive with acute type B aortic dissection enrolled in the International Registry of Acute Aortic Dissection (IRAD) between 1996 and 2003. Kaplan-Meier survival curves were constructed, and Cox proportional hazards analysis was performed to identify independent predictors of follow-up mortality. Three-year survival for patients treated medically, surgically, or with endovascular therapy was 77.6±6.6%, 82.8±18.9%, and 76.2±25.2%, respectively (median follow-up 2.3 years, log-rank P=0.61). Independent predictors of follow-up mortality included female gender (hazard ratio [HR], 1.99; 95% confidence interval [CI], 1.07 to 3.71; P=0.03), a history of prior aortic aneurysm (HR, 2.17; 95% CI, 1.03 to 4.59; P=0.04), a history of atherosclerosis (HR, 2.48; 95% CI, 1.32 to 4.66; P

Original languageEnglish
Pages (from-to)2226-2231
Number of pages6
JournalCirculation
Volume114
Issue number21
DOIs
Publication statusPublished - Nov 2006

Keywords

  • Aorta
  • Follow-up studies
  • Mortality
  • Risk factors

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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