Abstract
Objective: This study aimed to analyze long-term survival of clear cells (CCs) and endometrioid (E) ovarian cancer cases according to presence of endometriosis in the pathologic report. Methods: This is a retrospective analysis of 47 CC and 66 E ovarian cancer cases observed consecutively at our center between 1990 and 2010. All cases had first surgery at our center or were referred to it for treatment and follow-up. Cases were identified according to the original diagnosis reported in clinical records. All pathologic reports were reviewed, and cases were classified with or without pathologic evidence of endometriosis on the basis of the pathologic report. Follow-upwas updated in March 2011. The follow-up medianwas 147months (range, 116Y171). Results: Endometriosis-associated ovarian cancer cases were more frequently diagnosed at stage I to II than cases without endometriosis: among the 36 endometriosis-associated ovarian cancer cases, 25 (69%) were at stage I or II, and the corresponding value was 35 (46%) of 77 among cases without endometriosis (P = 0.0173). The presence of endometriosis tended to be associated with a higher 10-year survival rate: after taking the potential confounding effect of stage into account, the finding was not statistically significant (hazards ratio, 0.7; 95% confidence interval, 0.3Y1.5). Conclusions: This analysis shows that EA CCs and E ovarian cases are diagnosed at an earlier stage than cases without endometriosis. No clear association emerged between presence of endometriosis and survival.
| Original language | English |
|---|---|
| Pages (from-to) | 244-248 |
| Number of pages | 5 |
| Journal | International Journal of Gynecological Cancer |
| Volume | 23 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2013 |
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Keywords
- Endometriosis
- Ovarian cancer
- Survival
ASJC Scopus subject areas
- Obstetrics and Gynaecology
- Oncology
Cite this
Long term survival of ovarian endometriosis associated clear cell and endometrioid ovarian cancers. / Noli, Stefania; Cipriani, Sonia; Scarfone, Giovanna; Villa, Antonella; Grossi, Elena; Monti, Ermelinda; Vercellini, Paolo; Parazzini, Fabio.
In: International Journal of Gynecological Cancer, Vol. 23, No. 2, 02.2013, p. 244-248.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Long term survival of ovarian endometriosis associated clear cell and endometrioid ovarian cancers
AU - Noli, Stefania
AU - Cipriani, Sonia
AU - Scarfone, Giovanna
AU - Villa, Antonella
AU - Grossi, Elena
AU - Monti, Ermelinda
AU - Vercellini, Paolo
AU - Parazzini, Fabio
PY - 2013/2
Y1 - 2013/2
N2 - Objective: This study aimed to analyze long-term survival of clear cells (CCs) and endometrioid (E) ovarian cancer cases according to presence of endometriosis in the pathologic report. Methods: This is a retrospective analysis of 47 CC and 66 E ovarian cancer cases observed consecutively at our center between 1990 and 2010. All cases had first surgery at our center or were referred to it for treatment and follow-up. Cases were identified according to the original diagnosis reported in clinical records. All pathologic reports were reviewed, and cases were classified with or without pathologic evidence of endometriosis on the basis of the pathologic report. Follow-upwas updated in March 2011. The follow-up medianwas 147months (range, 116Y171). Results: Endometriosis-associated ovarian cancer cases were more frequently diagnosed at stage I to II than cases without endometriosis: among the 36 endometriosis-associated ovarian cancer cases, 25 (69%) were at stage I or II, and the corresponding value was 35 (46%) of 77 among cases without endometriosis (P = 0.0173). The presence of endometriosis tended to be associated with a higher 10-year survival rate: after taking the potential confounding effect of stage into account, the finding was not statistically significant (hazards ratio, 0.7; 95% confidence interval, 0.3Y1.5). Conclusions: This analysis shows that EA CCs and E ovarian cases are diagnosed at an earlier stage than cases without endometriosis. No clear association emerged between presence of endometriosis and survival.
AB - Objective: This study aimed to analyze long-term survival of clear cells (CCs) and endometrioid (E) ovarian cancer cases according to presence of endometriosis in the pathologic report. Methods: This is a retrospective analysis of 47 CC and 66 E ovarian cancer cases observed consecutively at our center between 1990 and 2010. All cases had first surgery at our center or were referred to it for treatment and follow-up. Cases were identified according to the original diagnosis reported in clinical records. All pathologic reports were reviewed, and cases were classified with or without pathologic evidence of endometriosis on the basis of the pathologic report. Follow-upwas updated in March 2011. The follow-up medianwas 147months (range, 116Y171). Results: Endometriosis-associated ovarian cancer cases were more frequently diagnosed at stage I to II than cases without endometriosis: among the 36 endometriosis-associated ovarian cancer cases, 25 (69%) were at stage I or II, and the corresponding value was 35 (46%) of 77 among cases without endometriosis (P = 0.0173). The presence of endometriosis tended to be associated with a higher 10-year survival rate: after taking the potential confounding effect of stage into account, the finding was not statistically significant (hazards ratio, 0.7; 95% confidence interval, 0.3Y1.5). Conclusions: This analysis shows that EA CCs and E ovarian cases are diagnosed at an earlier stage than cases without endometriosis. No clear association emerged between presence of endometriosis and survival.
KW - Endometriosis
KW - Ovarian cancer
KW - Survival
UR - http://www.scopus.com/inward/record.url?scp=84876256328&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84876256328&partnerID=8YFLogxK
U2 - 10.1097/IGC.0b013e31827aa0bb
DO - 10.1097/IGC.0b013e31827aa0bb
M3 - Article
VL - 23
SP - 244
EP - 248
JO - International Journal of Gynecological Cancer
JF - International Journal of Gynecological Cancer
SN - 1048-891X
IS - 2
ER -