Long-term survival outcomes of reduced-intensity allogeneic or autologous transplantation in relapsed grade 3 follicular lymphoma

E. Klyuchnikov, U. Bacher, K. Woo Ahn, J. Carreras, N. M. Kröger, P. N. Hari, G. H. Ku, E. Ayala, A. I. Chen, Y. B. Chen, J. B. Cohen, C. O. Freytes, R. P. Gale, R. T. Kamble, M. A. Kharfan-Dabaja, H. M. Lazarus, R. Martino, A. Mussetti, B. N. Savani, H. C. SchoutenS. Z. Usmani, P. H. Wiernik, B. Wirk, S. M. Smith, A. Sureda, M. Hamadani

Research output: Contribution to journalArticlepeer-review

Abstract

Grade 3 follicular lymphoma (FL) has aggressive clinical behavior. To evaluate the optimal first transplantation approach in relapsed/refractory grade 3 FL patients, we compared the long-term outcomes after allogeneic (allo-) vs autologous hematopoietic cell transplantation (auto-HCT) in the rituximab era. A total of 197 patients undergoing first reduced-intensity conditioning (RIC) allo-HCT or first auto-HCT during 2000-2012 were included. Rituximab-naive patients were excluded. Allo-HCT recipients were younger, more heavily pretreated and had a longer interval between diagnosis and HCT. The 5-year probabilities of non-relapse mortality (NRM), relapse/progression, PFS and overall survival (OS) for auto-HCT vs allo-HCT groups were 4% vs 27% (P

Original languageEnglish
Pages (from-to)58-66
Number of pages9
JournalBone Marrow Transplantation
Volume51
Issue number1
DOIs
Publication statusPublished - Jan 1 2016

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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