TY - JOUR
T1 - Long-term sympathoinhibitory effects of surgically induced weight loss in severe obese patients
AU - Seravalle, Gino
AU - Colombo, Manuela
AU - Perego, Paolo
AU - Giardini, Vittorio
AU - Volpe, Marco
AU - Dell'Oro, Raffaella
AU - Mancia, Giuseppe
AU - Grassi, Guido
PY - 2014
Y1 - 2014
N2 - Weight loss improves insulin sensitivity and exerts sympathomodulatory effects. No data, however, are available on the effects of the weight loss induced by vertical sleeve gastrectomy on sympathetic neural drive, insulin sensitivity, and their reciprocal cross talks. In 10 severe obese hypertensives (age, 54.0±2.3 years [mean±SEM]), we measured sphygmomanometric blood pressure, heart rate, body mass index, homeostatic model assessment index, plasma leptin, muscle sympathetic nerve traffic (microneurography), and baroreflex sensitivity (vasoactive drug technique). Measurements were performed 2 to 3 days before surgery and repeated 6 and 12 months after the procedure. Ten matched hypertensive obeses not undergoing gastrectomy served as controls. Six months after bariatric surgery, a significant (P
AB - Weight loss improves insulin sensitivity and exerts sympathomodulatory effects. No data, however, are available on the effects of the weight loss induced by vertical sleeve gastrectomy on sympathetic neural drive, insulin sensitivity, and their reciprocal cross talks. In 10 severe obese hypertensives (age, 54.0±2.3 years [mean±SEM]), we measured sphygmomanometric blood pressure, heart rate, body mass index, homeostatic model assessment index, plasma leptin, muscle sympathetic nerve traffic (microneurography), and baroreflex sensitivity (vasoactive drug technique). Measurements were performed 2 to 3 days before surgery and repeated 6 and 12 months after the procedure. Ten matched hypertensive obeses not undergoing gastrectomy served as controls. Six months after bariatric surgery, a significant (P
KW - bariatric surgery
KW - baroreflex
KW - body weight
KW - insulin resistance
KW - leptin
KW - obesity
KW - sympathetic nervous system
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U2 - 10.1161/HYPERTENSIONAHA.113.02988
DO - 10.1161/HYPERTENSIONAHA.113.02988
M3 - Article
C2 - 24866140
AN - SCOPUS:84904473198
VL - 64
SP - 431
EP - 437
JO - Hypertension
JF - Hypertension
SN - 0194-911X
IS - 2
ER -