Long-term sympathoinhibitory effects of surgically induced weight loss in severe obese patients

Gino Seravalle, Manuela Colombo, Paolo Perego, Vittorio Giardini, Marco Volpe, Raffaella Dell'Oro, Giuseppe Mancia, Guido Grassi

Research output: Contribution to journalArticlepeer-review

Abstract

Weight loss improves insulin sensitivity and exerts sympathomodulatory effects. No data, however, are available on the effects of the weight loss induced by vertical sleeve gastrectomy on sympathetic neural drive, insulin sensitivity, and their reciprocal cross talks. In 10 severe obese hypertensives (age, 54.0±2.3 years [mean±SEM]), we measured sphygmomanometric blood pressure, heart rate, body mass index, homeostatic model assessment index, plasma leptin, muscle sympathetic nerve traffic (microneurography), and baroreflex sensitivity (vasoactive drug technique). Measurements were performed 2 to 3 days before surgery and repeated 6 and 12 months after the procedure. Ten matched hypertensive obeses not undergoing gastrectomy served as controls. Six months after bariatric surgery, a significant (P

Original languageEnglish
Pages (from-to)431-437
Number of pages7
JournalHypertension
Volume64
Issue number2
DOIs
Publication statusPublished - 2014

Keywords

  • bariatric surgery
  • baroreflex
  • body weight
  • insulin resistance
  • leptin
  • obesity
  • sympathetic nervous system

ASJC Scopus subject areas

  • Internal Medicine

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