Long-term therapy with carbamazepine: Effects on nerve conduction velocity

S. Traccis, F. Monaco, G. P. Sechi, A. Moglia, R. Mutani

Research output: Contribution to journalArticlepeer-review


Peripheral nerve function was evaluated in 30 epileptic patients on chronic therapy with carbamazepine (CBZ) and 20 healthy controls. The electrophysiological data indicated a mild progressive reduction of both motor and sensory conduction velocity in the patients on long-term treatment with the drug. The impairment of nerve function paralleled the duration of therapy (i.e. 1 through 3 years). CBZ plasma levels were constantly within the therapeutic range. Folic acid levels were below normal in about 50% of the subjects. In the absence of other evidence, the hypothesis cannot be excluded that folate deficiency may have played some role in the development of the peripheral nerve dysfunction.

Original languageEnglish
Pages (from-to)410-416
Number of pages7
JournalEuropean Neurology
Issue number6
Publication statusPublished - 1983

ASJC Scopus subject areas

  • Clinical Neurology


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