Long-term treatment of psychotic (delusional) depression with fluvoxamine: An open pilot study

R. Zanardi, L. Franchini, M. Gasperini, E. Smeraldi, J. Perez

Research output: Contribution to journalArticle


The aim of this open pilot study was to evaluate the efficacy of fluvoxamine in the continuation as well as in the maintenance therapy of delusional depression. Thirty patients with recurrent, unipolar depression (DSM-IV criteria) were selected who had had at least one depressive episode during the 18 months preceding the delusional depressive index episode and were treated with fluvoxamine 300 mg/day. Twenty-five of them had a sustained response to this short-term treatment and agreed to enter into the 30-month follow up study All participants completed the follow up period. No relapse was observed during the 6 months of continuation therapy. During the further 24 months of maintenance therapy, 80% of the patients remained well, whereas 20% (five out of 25) had a single recurrence. Based on these observations, fluvoxaminc might be a promising drug for long-term therapy of delusional depression. Further controlled studies are required to confirm this finding.

Original languageEnglish
Pages (from-to)195-197
Number of pages3
JournalInternational Clinical Psychopharmacology
Issue number4
Publication statusPublished - 1997


  • Continuation treatment
  • Fluvoxamine
  • Maintenance treatment
  • Psychotic (delusional) depression

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)
  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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