Long term treatment of the hyperkinetic heart syndrome with propranolol

M. Guazzi, A. Polese, F. Magrini, C. Fiorentini, M. T. Olivari

Research output: Contribution to journalArticle

Abstract

Twelve men suffering from the primary hyperkinetic heart syndrome (PHHS) displayed palpitation, rapid and forceful heart action, increased pulsations of the large arteries, cardiac systolic murmur, and the following circulatory values (averages): systolic arterial pressure (SAP) = 154 mm Hg; heart rate (HR) = 91 b/min; cardiac index (CI) = 5494 ml/min/m 2; left ventricular mean systolic ejection rate index (MSEJR) = 227 ml/min/m 2; left ventricular mean pre ejection ΔP/Δt = 1.32 mm Hg/msec. A two year followup during which propranolol was administered (80-160 mg/day) revealed good subjective improvement and disappearance of signs of circulatory hyperkinesis. At the end of this period the hemodynamic functions were as follows: SAP = 134; HR = 69; CI = 3489; MSEJR = 171; ΔP/Δt = 0.89. Substitution of placebo for the active drug caused prompt reappearance of symptoms of cardiac overactivity in each patient, and brought the circulatory functions back to these levels: SAP = 157; HR = 96; CI = 5530; MSEJR = 245; ΔP/Δt = 1.33. These findings lend further credence to the concept that the PHHS is, indeed, a definable disease entity; they also document that propranolol ameliorates the symptoms of the disease but is ineffective for the underlying disorder.

Original languageEnglish
Pages (from-to)465-474
Number of pages10
JournalAmerican Journal of the Medical Sciences
Volume270
Issue number3
DOIs
Publication statusPublished - 1975

Fingerprint

Neurocirculatory Asthenia
Propranolol
Arterial Pressure
Heart Rate
Blood Pressure
Systolic Murmurs
Hyperkinesis
Heart Murmurs
Therapeutics
Arteries
Hemodynamics
Placebos
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Long term treatment of the hyperkinetic heart syndrome with propranolol. / Guazzi, M.; Polese, A.; Magrini, F.; Fiorentini, C.; Olivari, M. T.

In: American Journal of the Medical Sciences, Vol. 270, No. 3, 1975, p. 465-474.

Research output: Contribution to journalArticle

Guazzi, M. ; Polese, A. ; Magrini, F. ; Fiorentini, C. ; Olivari, M. T. / Long term treatment of the hyperkinetic heart syndrome with propranolol. In: American Journal of the Medical Sciences. 1975 ; Vol. 270, No. 3. pp. 465-474.
@article{6a9872fd1c6d46b598d15159e1dc482e,
title = "Long term treatment of the hyperkinetic heart syndrome with propranolol",
abstract = "Twelve men suffering from the primary hyperkinetic heart syndrome (PHHS) displayed palpitation, rapid and forceful heart action, increased pulsations of the large arteries, cardiac systolic murmur, and the following circulatory values (averages): systolic arterial pressure (SAP) = 154 mm Hg; heart rate (HR) = 91 b/min; cardiac index (CI) = 5494 ml/min/m 2; left ventricular mean systolic ejection rate index (MSEJR) = 227 ml/min/m 2; left ventricular mean pre ejection ΔP/Δt = 1.32 mm Hg/msec. A two year followup during which propranolol was administered (80-160 mg/day) revealed good subjective improvement and disappearance of signs of circulatory hyperkinesis. At the end of this period the hemodynamic functions were as follows: SAP = 134; HR = 69; CI = 3489; MSEJR = 171; ΔP/Δt = 0.89. Substitution of placebo for the active drug caused prompt reappearance of symptoms of cardiac overactivity in each patient, and brought the circulatory functions back to these levels: SAP = 157; HR = 96; CI = 5530; MSEJR = 245; ΔP/Δt = 1.33. These findings lend further credence to the concept that the PHHS is, indeed, a definable disease entity; they also document that propranolol ameliorates the symptoms of the disease but is ineffective for the underlying disorder.",
author = "M. Guazzi and A. Polese and F. Magrini and C. Fiorentini and Olivari, {M. T.}",
year = "1975",
doi = "10.1097/00000441-197511000-00007",
language = "English",
volume = "270",
pages = "465--474",
journal = "American Journal of the Medical Sciences",
issn = "0002-9629",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Long term treatment of the hyperkinetic heart syndrome with propranolol

AU - Guazzi, M.

AU - Polese, A.

AU - Magrini, F.

AU - Fiorentini, C.

AU - Olivari, M. T.

PY - 1975

Y1 - 1975

N2 - Twelve men suffering from the primary hyperkinetic heart syndrome (PHHS) displayed palpitation, rapid and forceful heart action, increased pulsations of the large arteries, cardiac systolic murmur, and the following circulatory values (averages): systolic arterial pressure (SAP) = 154 mm Hg; heart rate (HR) = 91 b/min; cardiac index (CI) = 5494 ml/min/m 2; left ventricular mean systolic ejection rate index (MSEJR) = 227 ml/min/m 2; left ventricular mean pre ejection ΔP/Δt = 1.32 mm Hg/msec. A two year followup during which propranolol was administered (80-160 mg/day) revealed good subjective improvement and disappearance of signs of circulatory hyperkinesis. At the end of this period the hemodynamic functions were as follows: SAP = 134; HR = 69; CI = 3489; MSEJR = 171; ΔP/Δt = 0.89. Substitution of placebo for the active drug caused prompt reappearance of symptoms of cardiac overactivity in each patient, and brought the circulatory functions back to these levels: SAP = 157; HR = 96; CI = 5530; MSEJR = 245; ΔP/Δt = 1.33. These findings lend further credence to the concept that the PHHS is, indeed, a definable disease entity; they also document that propranolol ameliorates the symptoms of the disease but is ineffective for the underlying disorder.

AB - Twelve men suffering from the primary hyperkinetic heart syndrome (PHHS) displayed palpitation, rapid and forceful heart action, increased pulsations of the large arteries, cardiac systolic murmur, and the following circulatory values (averages): systolic arterial pressure (SAP) = 154 mm Hg; heart rate (HR) = 91 b/min; cardiac index (CI) = 5494 ml/min/m 2; left ventricular mean systolic ejection rate index (MSEJR) = 227 ml/min/m 2; left ventricular mean pre ejection ΔP/Δt = 1.32 mm Hg/msec. A two year followup during which propranolol was administered (80-160 mg/day) revealed good subjective improvement and disappearance of signs of circulatory hyperkinesis. At the end of this period the hemodynamic functions were as follows: SAP = 134; HR = 69; CI = 3489; MSEJR = 171; ΔP/Δt = 0.89. Substitution of placebo for the active drug caused prompt reappearance of symptoms of cardiac overactivity in each patient, and brought the circulatory functions back to these levels: SAP = 157; HR = 96; CI = 5530; MSEJR = 245; ΔP/Δt = 1.33. These findings lend further credence to the concept that the PHHS is, indeed, a definable disease entity; they also document that propranolol ameliorates the symptoms of the disease but is ineffective for the underlying disorder.

UR - http://www.scopus.com/inward/record.url?scp=0016688344&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016688344&partnerID=8YFLogxK

U2 - 10.1097/00000441-197511000-00007

DO - 10.1097/00000441-197511000-00007

M3 - Article

C2 - 129002

AN - SCOPUS:0016688344

VL - 270

SP - 465

EP - 474

JO - American Journal of the Medical Sciences

JF - American Journal of the Medical Sciences

SN - 0002-9629

IS - 3

ER -