Long-term treatment with citalopram in patients with highly recurrent forms of unipolar depression

Linda Franchini, Chiara Spagnolo, Raffaella Rampoldi, Raffaella Zanardi, Enrico Smeraldi

Research output: Contribution to journalArticlepeer-review

Abstract

The authors evaluated the efficacy and safety of citalopram in a 28-month study in 48 inpatients with highly recurrent forms of unipolar depression. The patients, who each had at least one depressive episode during the 18 months preceding the index episode, were openly treated with citalopram, 40 mg/day. Thirty-six of the patients had a stable response to citalopram and continued treatment as outpatients for 4 months. No relapses were observed. At the time of recovery, 32/36 subjects received maintenance treatment with citalopram (40 mg) for an additional 24 months. At the end of the study, 11/32 patients experienced a single new recurrence.

Original languageEnglish
Pages (from-to)129-133
Number of pages5
JournalPsychiatry Research
Volume105
Issue number1-2
DOIs
Publication statusPublished - Dec 15 2001

Keywords

  • Long-term therapy
  • Prevention
  • Recurrent major depression
  • Relapse
  • Selective serotonin reuptake inhibitors

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

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