Interferon (IFN)-β has become a widespread therapy for multiple sclerosis. As already reported for IFN-α, thyroid autoimmunity and dysfunctions have been observed also in course of IFN-β therapy. Nevertheless, very few cases of Graves' disease, occurred in such condition, have been reported in literature. We here describe the case of a 40-year-old female affected by multiple sclerosis, who received IFN-β-1b, 8 million IU sc every other day for her condition. After 22 months of cytokine administration, she developed a severe Graves' disease with persistently positive TRAb which suggested the withdrawal of the treatment. Our patient had performed a complete thyroid evaluation with normal findings, before and during the first 6 months of therapy. This case suggests that patients undergoing long-term IFN-β therapy should be monitored for thyroid hormones and antibodies throughout the treatment as thyroidal side effect can be a late event. (C)2000, Editrice Kurtis.
|Number of pages||4|
|Journal||Journal of Endocrinological Investigation|
|Publication status||Published - 2000|
- Multiple sclerosis
- Thyroid autoimmunity
ASJC Scopus subject areas