Long-term urologic outcome in patients with caudal regression syndrome, compared with meningomyelocele and spinal cord lipoma

Michele Torre, Piero Buffa, Vincenzo Jasonni, Armando Cama

Research output: Contribution to journalArticlepeer-review

Abstract

Background/Purpose: The long-term urologic outcome in a large series of patients with neural tube defects was evaluated. Methods: The following clinical parameters in 398 patients ranging from 1 to 37 years of age-69 with caudal regression syndrome (CRS), 244 with meningomyelocele (MMC), and 85 with spinal lipoma (SL)-were studied: congenital renal anomalies, renal function, vesico-ureteric reflux, upper tract dilatation, urodynamic pattern, and urinary continence. Results: Single kidney was much more frequent in CRS (20.3%), compared with MMC (1.2%) and SL (0%). Vesico-ureteric reflux was found in 37.7% of patients with CRS, 43.0% of MMC, and 21.2% of SL. Patients with CRS had a higher risk of impaired renal function (8.7%), compared with MMC (5.3%) and SL (1.2%). Neuropathic bladder was found in 61% of patients with CRS, 98% of MMC, and 42% of SL. Among them, clean intermittent catheterization and drugs allowed 30% of patients with CRS, 45% of MMC, and 71% of SL to be dry for more than 4 hours. Conclusions: Diagnosis influences the urologic outcome in neural tube defect. In CRS, the incidence of renal agenesis and vesico-ureteric reflux was unexpectedly high. The risk of renal damage and, in those with neuropathic bladder, of urinary incontinence, was similar to patients with MMC.

Original languageEnglish
Pages (from-to)530-533
Number of pages4
JournalJournal of Pediatric Surgery
Volume43
Issue number3
DOIs
Publication statusPublished - Mar 2008

Keywords

  • Caudal regression syndrome
  • Meningomyelocele
  • Neural tube defects
  • Neurogenic bladder
  • Spina bifida
  • Spinal lipoma

ASJC Scopus subject areas

  • Surgery

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