Long-term visual outcome and its predictors in macular oedema secondary to retinal vein occlusion treated with dexamethasone implant

Catharina Busch, Matus Rehak, Chintan Sarvariya, Dinah Zur, Matias Iglicki, Luiz H. Lima, Alessandro Invernizzi, Francesco Viola, Kushal Agrawal, Suthasinee Sinawat, Aude Couturier, Aanchal Mehta, Rakesh Juneja, Hardik Jain, Aniruddha Kishandutt Agarwal, Neha Goel, Manish Nagpal, Vishali Gupta, Alay Banker, Anat LoewensteinMali Okada, Ali Osman Saatci, Ahmad M. Mansour, Jay Chhablani

Research output: Contribution to journalArticlepeer-review

Abstract

Background: To evaluate the functional long-term outcome in patients with macular oedema (MO) secondary to central retinal vein occlusion (CRVO) and branch retinal vein occlusion (BRVO) treated with dexamethasone implant (DEX implant) and to identify its clinical predictors. Methods: A 24-month, retrospective, multinational, real-world study. Chart review of patients with either naïve or recurrent MO secondary to CRVO/BRVO treated with DEX implant, including best-corrected visual acuity (BCVA), central subfield thickness (CST), demographic baseline characteristics and details of any additional treatment during follow-up. Results: A total of 155 eyes (65 CRVO, 90 BRVO) from 155 patients were included. At 24 months, mean BCVA did not change significantly in CRVO ('2.1±24.5 letters, p=0.96) and BRVO patients (1.3±27.0 letters, p=0.07). A worse baseline BCVA (p<0.001), visual acuity (VA) gain ≥5 letters at 2 months (p=0.006) and no need for adjunctive intravitreal therapy after first DEX implant (p=0.001) were associated with a better final BCVA gain. Treatment-naïve patients (p=0.006, OR: 0.25, 95% CI 0.11 to 0.57) and those with a baseline CST≤400 μm (p=0.02, OR: 0.25, 95% CI 0.10 to 0.63) were identified as being less likely to need additional intravitreal therapy. Conclusion: Clinical baseline characteristics and the early treatment response were identified as possible predictors for long-term outcome and the need of adjunctive intravitreal therapy in MO secondary to BRVO/CRVO treated by DEX implant.

Original languageEnglish
Pages (from-to)463-468
JournalBritish Journal of Ophthalmology
Volume103
Issue number4
DOIs
Publication statusPublished - 2019

Keywords

  • Long-term outcome

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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