Longitudinal assessment of coronary plaque volume change related to glycemic status using serial coronary computed tomography angiography

A PARADIGM (Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography Imaging) substudy

Ki Bum Won, Sang Eun Lee, Byoung Kwon Lee, Hyung Bok Park, Ran Heo, Asim Rizvi, Fay Y. Lin, Amit Kumar, Martin Hadamitzky, Yong Jin Kim, Ji Min Sung, Edoardo Conte, Daniele Andreini, Gianluca Pontone, Matthew J. Budoff, Ilan Gottlieb, Eun Ju Chun, Filippo Cademartiri, Erica Maffei, Hugo Marques & 14 others Jonathon A. Leipsic, Sanghoon Shin, Jung Hyun Choi, Renu Virmani, Habib Samady, Kavitha Chinnaiyan, Gilbert L. Raff, Peter H. Stone, Daniel S. Berman, Jagat Narula, Leslee J. Shaw, Jeroen J. Bax, James K. Min, Hyuk Jae Chang

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Data on the impact of glycemic status on coronary plaque progression have been limited. This study evaluated the association between glycemic status and coronary plaque volume change (PVC) using coronary computed tomography angiography (CCTA). Methods: A total of 1296 subjects (61 ± 9, 56.9% male) who underwent serial CCTA with available glycemic status were enrolled and analyzed from the Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry. The median inter-scan period was 3.2 (2.6–4.4) years. Quantitative assessment of coronary plaques was performed at both scans. All participants were categorized into the following groups according to glycemic status: normal, pre-diabetes (pre-DM), and diabetes mellitus (DM). Results: During the follow-up, significant differences in PVC (normal: 51.3 ± 83.3 mm3 vs. pre-DM: 51.0 ± 84.3 mm3 vs. DM: 72.6 ± 95.0 mm3; p < 0.001) and annualized PVC (normal: 14.9 ± 24.9 mm3 vs. pre-DM: 15.7 ± 23.8 mm3 vs. DM: 21.0 ± 27.7 mm3; p = 0.001) were observed among the 3 groups. Compared with normal individuals, individuals with pre-DM showed no significant differences in the adjusted odds ratio (OR) for plaque progression (PP) (1.338, 95% confidence interval [CI] 0.967–1.853; p = 0.079). However, the adjusted OR for PP was higher in DM individuals than in normal individuals (1.635, 95% CI 1.126–2.375; p = 0.010). Conclusion: DM had an incremental impact on coronary PP, but pre-DM appeared to have no significant association with an increased risk of coronary PP after adjusting for confounding factors. Clinical trial registration: ClinicalTrials.gov NCT02803411.

Original languageEnglish
JournalJournal of Cardiovascular Computed Tomography
DOIs
Publication statusAccepted/In press - Jan 1 2018

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Atherosclerotic Plaques
Diabetes Mellitus
Angiography
Odds Ratio
Computed Tomography Angiography
Confidence Intervals
Registries
Clinical Trials

Keywords

  • Coronary atherosclerosis
  • Coronary computed tomography angiography
  • Pre-diabetes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Longitudinal assessment of coronary plaque volume change related to glycemic status using serial coronary computed tomography angiography : A PARADIGM (Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography Imaging) substudy. / Won, Ki Bum; Lee, Sang Eun; Lee, Byoung Kwon; Park, Hyung Bok; Heo, Ran; Rizvi, Asim; Lin, Fay Y.; Kumar, Amit; Hadamitzky, Martin; Kim, Yong Jin; Sung, Ji Min; Conte, Edoardo; Andreini, Daniele; Pontone, Gianluca; Budoff, Matthew J.; Gottlieb, Ilan; Chun, Eun Ju; Cademartiri, Filippo; Maffei, Erica; Marques, Hugo; Leipsic, Jonathon A.; Shin, Sanghoon; Choi, Jung Hyun; Virmani, Renu; Samady, Habib; Chinnaiyan, Kavitha; Raff, Gilbert L.; Stone, Peter H.; Berman, Daniel S.; Narula, Jagat; Shaw, Leslee J.; Bax, Jeroen J.; Min, James K.; Chang, Hyuk Jae.

In: Journal of Cardiovascular Computed Tomography, 01.01.2018.

Research output: Contribution to journalArticle

Won, KB, Lee, SE, Lee, BK, Park, HB, Heo, R, Rizvi, A, Lin, FY, Kumar, A, Hadamitzky, M, Kim, YJ, Sung, JM, Conte, E, Andreini, D, Pontone, G, Budoff, MJ, Gottlieb, I, Chun, EJ, Cademartiri, F, Maffei, E, Marques, H, Leipsic, JA, Shin, S, Choi, JH, Virmani, R, Samady, H, Chinnaiyan, K, Raff, GL, Stone, PH, Berman, DS, Narula, J, Shaw, LJ, Bax, JJ, Min, JK & Chang, HJ 2018, 'Longitudinal assessment of coronary plaque volume change related to glycemic status using serial coronary computed tomography angiography: A PARADIGM (Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography Imaging) substudy', Journal of Cardiovascular Computed Tomography. https://doi.org/10.1016/j.jcct.2018.12.002
Won, Ki Bum ; Lee, Sang Eun ; Lee, Byoung Kwon ; Park, Hyung Bok ; Heo, Ran ; Rizvi, Asim ; Lin, Fay Y. ; Kumar, Amit ; Hadamitzky, Martin ; Kim, Yong Jin ; Sung, Ji Min ; Conte, Edoardo ; Andreini, Daniele ; Pontone, Gianluca ; Budoff, Matthew J. ; Gottlieb, Ilan ; Chun, Eun Ju ; Cademartiri, Filippo ; Maffei, Erica ; Marques, Hugo ; Leipsic, Jonathon A. ; Shin, Sanghoon ; Choi, Jung Hyun ; Virmani, Renu ; Samady, Habib ; Chinnaiyan, Kavitha ; Raff, Gilbert L. ; Stone, Peter H. ; Berman, Daniel S. ; Narula, Jagat ; Shaw, Leslee J. ; Bax, Jeroen J. ; Min, James K. ; Chang, Hyuk Jae. / Longitudinal assessment of coronary plaque volume change related to glycemic status using serial coronary computed tomography angiography : A PARADIGM (Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography Imaging) substudy. In: Journal of Cardiovascular Computed Tomography. 2018.
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title = "Longitudinal assessment of coronary plaque volume change related to glycemic status using serial coronary computed tomography angiography: A PARADIGM (Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography Imaging) substudy",
abstract = "Background: Data on the impact of glycemic status on coronary plaque progression have been limited. This study evaluated the association between glycemic status and coronary plaque volume change (PVC) using coronary computed tomography angiography (CCTA). Methods: A total of 1296 subjects (61 ± 9, 56.9{\%} male) who underwent serial CCTA with available glycemic status were enrolled and analyzed from the Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry. The median inter-scan period was 3.2 (2.6–4.4) years. Quantitative assessment of coronary plaques was performed at both scans. All participants were categorized into the following groups according to glycemic status: normal, pre-diabetes (pre-DM), and diabetes mellitus (DM). Results: During the follow-up, significant differences in PVC (normal: 51.3 ± 83.3 mm3 vs. pre-DM: 51.0 ± 84.3 mm3 vs. DM: 72.6 ± 95.0 mm3; p < 0.001) and annualized PVC (normal: 14.9 ± 24.9 mm3 vs. pre-DM: 15.7 ± 23.8 mm3 vs. DM: 21.0 ± 27.7 mm3; p = 0.001) were observed among the 3 groups. Compared with normal individuals, individuals with pre-DM showed no significant differences in the adjusted odds ratio (OR) for plaque progression (PP) (1.338, 95{\%} confidence interval [CI] 0.967–1.853; p = 0.079). However, the adjusted OR for PP was higher in DM individuals than in normal individuals (1.635, 95{\%} CI 1.126–2.375; p = 0.010). Conclusion: DM had an incremental impact on coronary PP, but pre-DM appeared to have no significant association with an increased risk of coronary PP after adjusting for confounding factors. Clinical trial registration: ClinicalTrials.gov NCT02803411.",
keywords = "Coronary atherosclerosis, Coronary computed tomography angiography, Pre-diabetes",
author = "Won, {Ki Bum} and Lee, {Sang Eun} and Lee, {Byoung Kwon} and Park, {Hyung Bok} and Ran Heo and Asim Rizvi and Lin, {Fay Y.} and Amit Kumar and Martin Hadamitzky and Kim, {Yong Jin} and Sung, {Ji Min} and Edoardo Conte and Daniele Andreini and Gianluca Pontone and Budoff, {Matthew J.} and Ilan Gottlieb and Chun, {Eun Ju} and Filippo Cademartiri and Erica Maffei and Hugo Marques and Leipsic, {Jonathon A.} and Sanghoon Shin and Choi, {Jung Hyun} and Renu Virmani and Habib Samady and Kavitha Chinnaiyan and Raff, {Gilbert L.} and Stone, {Peter H.} and Berman, {Daniel S.} and Jagat Narula and Shaw, {Leslee J.} and Bax, {Jeroen J.} and Min, {James K.} and Chang, {Hyuk Jae}",
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month = "1",
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TY - JOUR

T1 - Longitudinal assessment of coronary plaque volume change related to glycemic status using serial coronary computed tomography angiography

T2 - A PARADIGM (Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography Imaging) substudy

AU - Won, Ki Bum

AU - Lee, Sang Eun

AU - Lee, Byoung Kwon

AU - Park, Hyung Bok

AU - Heo, Ran

AU - Rizvi, Asim

AU - Lin, Fay Y.

AU - Kumar, Amit

AU - Hadamitzky, Martin

AU - Kim, Yong Jin

AU - Sung, Ji Min

AU - Conte, Edoardo

AU - Andreini, Daniele

AU - Pontone, Gianluca

AU - Budoff, Matthew J.

AU - Gottlieb, Ilan

AU - Chun, Eun Ju

AU - Cademartiri, Filippo

AU - Maffei, Erica

AU - Marques, Hugo

AU - Leipsic, Jonathon A.

AU - Shin, Sanghoon

AU - Choi, Jung Hyun

AU - Virmani, Renu

AU - Samady, Habib

AU - Chinnaiyan, Kavitha

AU - Raff, Gilbert L.

AU - Stone, Peter H.

AU - Berman, Daniel S.

AU - Narula, Jagat

AU - Shaw, Leslee J.

AU - Bax, Jeroen J.

AU - Min, James K.

AU - Chang, Hyuk Jae

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background: Data on the impact of glycemic status on coronary plaque progression have been limited. This study evaluated the association between glycemic status and coronary plaque volume change (PVC) using coronary computed tomography angiography (CCTA). Methods: A total of 1296 subjects (61 ± 9, 56.9% male) who underwent serial CCTA with available glycemic status were enrolled and analyzed from the Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry. The median inter-scan period was 3.2 (2.6–4.4) years. Quantitative assessment of coronary plaques was performed at both scans. All participants were categorized into the following groups according to glycemic status: normal, pre-diabetes (pre-DM), and diabetes mellitus (DM). Results: During the follow-up, significant differences in PVC (normal: 51.3 ± 83.3 mm3 vs. pre-DM: 51.0 ± 84.3 mm3 vs. DM: 72.6 ± 95.0 mm3; p < 0.001) and annualized PVC (normal: 14.9 ± 24.9 mm3 vs. pre-DM: 15.7 ± 23.8 mm3 vs. DM: 21.0 ± 27.7 mm3; p = 0.001) were observed among the 3 groups. Compared with normal individuals, individuals with pre-DM showed no significant differences in the adjusted odds ratio (OR) for plaque progression (PP) (1.338, 95% confidence interval [CI] 0.967–1.853; p = 0.079). However, the adjusted OR for PP was higher in DM individuals than in normal individuals (1.635, 95% CI 1.126–2.375; p = 0.010). Conclusion: DM had an incremental impact on coronary PP, but pre-DM appeared to have no significant association with an increased risk of coronary PP after adjusting for confounding factors. Clinical trial registration: ClinicalTrials.gov NCT02803411.

AB - Background: Data on the impact of glycemic status on coronary plaque progression have been limited. This study evaluated the association between glycemic status and coronary plaque volume change (PVC) using coronary computed tomography angiography (CCTA). Methods: A total of 1296 subjects (61 ± 9, 56.9% male) who underwent serial CCTA with available glycemic status were enrolled and analyzed from the Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry. The median inter-scan period was 3.2 (2.6–4.4) years. Quantitative assessment of coronary plaques was performed at both scans. All participants were categorized into the following groups according to glycemic status: normal, pre-diabetes (pre-DM), and diabetes mellitus (DM). Results: During the follow-up, significant differences in PVC (normal: 51.3 ± 83.3 mm3 vs. pre-DM: 51.0 ± 84.3 mm3 vs. DM: 72.6 ± 95.0 mm3; p < 0.001) and annualized PVC (normal: 14.9 ± 24.9 mm3 vs. pre-DM: 15.7 ± 23.8 mm3 vs. DM: 21.0 ± 27.7 mm3; p = 0.001) were observed among the 3 groups. Compared with normal individuals, individuals with pre-DM showed no significant differences in the adjusted odds ratio (OR) for plaque progression (PP) (1.338, 95% confidence interval [CI] 0.967–1.853; p = 0.079). However, the adjusted OR for PP was higher in DM individuals than in normal individuals (1.635, 95% CI 1.126–2.375; p = 0.010). Conclusion: DM had an incremental impact on coronary PP, but pre-DM appeared to have no significant association with an increased risk of coronary PP after adjusting for confounding factors. Clinical trial registration: ClinicalTrials.gov NCT02803411.

KW - Coronary atherosclerosis

KW - Coronary computed tomography angiography

KW - Pre-diabetes

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U2 - 10.1016/j.jcct.2018.12.002

DO - 10.1016/j.jcct.2018.12.002

M3 - Article

JO - Journal of Cardiovascular Computed Tomography

JF - Journal of Cardiovascular Computed Tomography

SN - 1934-5925

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