Longitudinal assessment of dentate nuclei relaxometry during massive gadobutrol exposure

Enrico Tedeschi, Sirio Cocozza, Pasquale Borrelli, Lorenzo Ugga, Vincenzo Brescia Morra, Giuseppe Palma

Research output: Contribution to journalArticlepeer-review


We report the assessment of Dentate Nuclei (DN) R1 (1/T1) and R2* (1/T2 *) values in a patient with relapsing-remitting Multiple Sclerosis, exposed to 22 standard (0.1 mmol/kg) doses of gadobutrol, who underwent eight relaxometric MR measurements within 2 years. DN R1 did not significantly increase nor correlated with cumulative gadobutrol administration, even after a total dose of 130 ml. Likewise, DN R2* relaxometry remained unchanged. In conclusion, massive gadobutrol exposure did not induce significant DN relaxometry changes.

Original languageEnglish
Pages (from-to)100-104
Number of pages5
JournalMagnetic Resonance in Medical Sciences
Issue number1
Publication statusE-pub ahead of print - Mar 27 2017


  • Dentate nucleus
  • Gadolinium
  • Magnetic resonance imaging contrast media
  • Multiple sclerosis
  • Relaxometry

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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