TY - JOUR
T1 - Longitudinal assessment of dentate nuclei relaxometry during massive gadobutrol exposure
AU - Tedeschi, Enrico
AU - Cocozza, Sirio
AU - Borrelli, Pasquale
AU - Ugga, Lorenzo
AU - Morra, Vincenzo Brescia
AU - Palma, Giuseppe
PY - 2017/3/27
Y1 - 2017/3/27
N2 - We report the assessment of Dentate Nuclei (DN) R1 (1/T1) and R2* (1/T2 *) values in a patient with relapsing-remitting Multiple Sclerosis, exposed to 22 standard (0.1 mmol/kg) doses of gadobutrol, who underwent eight relaxometric MR measurements within 2 years. DN R1 did not significantly increase nor correlated with cumulative gadobutrol administration, even after a total dose of 130 ml. Likewise, DN R2* relaxometry remained unchanged. In conclusion, massive gadobutrol exposure did not induce significant DN relaxometry changes.
AB - We report the assessment of Dentate Nuclei (DN) R1 (1/T1) and R2* (1/T2 *) values in a patient with relapsing-remitting Multiple Sclerosis, exposed to 22 standard (0.1 mmol/kg) doses of gadobutrol, who underwent eight relaxometric MR measurements within 2 years. DN R1 did not significantly increase nor correlated with cumulative gadobutrol administration, even after a total dose of 130 ml. Likewise, DN R2* relaxometry remained unchanged. In conclusion, massive gadobutrol exposure did not induce significant DN relaxometry changes.
KW - Dentate nucleus
KW - Gadolinium
KW - Magnetic resonance imaging contrast media
KW - Multiple sclerosis
KW - Relaxometry
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U2 - 10.2463/mrms.cr.2016-0137
DO - 10.2463/mrms.cr.2016-0137
M3 - Article
AN - SCOPUS:85040446108
VL - 17
SP - 100
EP - 104
JO - Magnetic Resonance in Medical Sciences
JF - Magnetic Resonance in Medical Sciences
SN - 1347-3182
IS - 1
ER -