Longitudinal assessment of levo-thyroxine therapy for congenital hypothyroidism: Relationship with aetiology, bone maturation and biochemical features

Maurizio Delvecchio, Maria Felicia Faienza, Angelo Acquafredda, Clara Zecchino, Sonia Peruzzi, Luciano Cavallo

Research output: Contribution to journalArticle

Abstract

Aims: To evaluate therapy and dose adjustments in patients with congenital hypothyroidism (CH), longitudinally followed up until 16 years old, according to aetiology, Beclard's nuclei presence, and thyroxine (T4) level at diagnosis. Methods:L-T4/kg/day and dose change ratio (CR) were assessed in 74 CH patients. Results: The dose was statistically larger in athyreosis than in dyshormonogenesis (1-10 and beyond 14 years) and in ectopy (2, 15, 16 years). The ectopic children required statistically larger L-T4/kg than the dyshormonogenetic ones (3-7 years). The L-T4/kg/day was increased, not statistically, in patients or with T4

Original languageEnglish
Pages (from-to)105-112
Number of pages8
JournalHormone Research
Volume68
Issue number3
DOIs
Publication statusPublished - Aug 2007

Keywords

  • Aetiology
  • Congenital hypothyroidism
  • Dose change
  • L-thyroxine treatment
  • Severity

ASJC Scopus subject areas

  • Endocrinology

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