Longitudinal changes in serum ferritin levels correlate with measures of hepatic stiffness in transfusion-independent patients with β-thalassemia intermedia

Khaled M. Musallam, Irene Motta, Marta Salvatori, Mirella Fraquelli, Alessia Marcon, Ali T. Taher, Maria Domenica Cappellini

Research output: Contribution to journalArticle

Abstract

Despite evidence of considerable iron overload in transfusion-independent patients with β-thalassemia intermedia, data on hepatic outcomes remain scarce. We analyzed data from a cohort of 42 β-thalassemia intermedia adults followed for four years (median age 38years), and evaluated the association between longitudinal changes in serum ferritin levels and transient elastography values, a measure of hepatic stiffness predictive of fibrosis. We observed a significant increase in both serum ferritin levels (+81.2 [μg/l]/year) and transient elastography values in non-chelated patients (n=28) (+0.3kPa/year), with two patients worsening their fibrosis stage. Chelated patients (n=14) had a significant decrease in both measures (-42.0 [μg/l]/year and -0.9kPa/year, respectively), with two patients improving their fibrosis stage. There was a strong correlation between the rate of change in serum ferritin level and the rate of change in transient elastography value (R2: 0.836, p

Original languageEnglish
Pages (from-to)136-139
Number of pages4
JournalBlood cells, molecules & diseases
Volume49
Issue number3-4
DOIs
Publication statusPublished - Oct 15 2012

Keywords

  • Chelation
  • Fibrosis
  • Iron
  • Liver
  • Thalassemia intermedia

ASJC Scopus subject areas

  • Molecular Biology
  • Molecular Medicine
  • Hematology
  • Cell Biology

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